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Protein

Malate synthase G

Gene

glcB

Organism
Brucella abortus str. 2308 A
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.UniRule annotationSAAS annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Pathwayi: glyoxylate cycle

This protein is involved in step 2 of the subpathway that synthesizes (S)-malate from isocitrate.UniRule annotationSAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Malate synthase G (glcB)
This subpathway is part of the pathway glyoxylate cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-malate from isocitrate, the pathway glyoxylate cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei123Acetyl-CoA; via carbonyl oxygenUniRule annotation1
Binding sitei281Acetyl-CoAUniRule annotation1
Binding sitei318Acetyl-CoAUniRule annotation1
Active sitei345Proton acceptorUniRule annotation1
Binding sitei345GlyoxylateUniRule annotation1
Metal bindingi437MagnesiumUniRule annotation1
Binding sitei437GlyoxylateUniRule annotation1
Metal bindingi465MagnesiumUniRule annotation1
Binding sitei546Acetyl-CoA; via carbonyl oxygenUniRule annotation1
Active sitei636Proton donorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationSAAS annotation
Biological processGlyoxylate bypassUniRule annotationSAAS annotation, Tricarboxylic acid cycleUniRule annotationSAAS annotation
LigandMagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00703; UER00720

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase GUniRule annotation (EC:2.3.3.9UniRule annotation)
Gene namesi
Name:glcBUniRule annotationImported
ORF Names:BAAA_3000014Imported
OrganismiBrucella abortus str. 2308 AImported
Taxonomic identifieri641140 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000003313 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei622Cysteine sulfenic acid (-SOH)UniRule annotation1

Keywords - PTMi

OxidationUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC4ISM0
SMRiC4ISM0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni130 – 131Acetyl-CoA bindingUniRule annotation2
Regioni462 – 465Glyoxylate bindingUniRule annotation4

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili55 – 75Sequence analysisAdd BLAST21
Coiled coili435 – 455Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the malate synthase family. GlcB subfamily.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

CDDicd00728 malate_synt_G, 1 hit
Gene3Di2.170.170.11, 1 hit
HAMAPiMF_00641 Malate_synth_G, 1 hit
InterProiView protein in InterPro
IPR011076 Malate_synth-like_sf
IPR023310 Malate_synth_G_beta_sub_dom
IPR001465 Malate_synthase
IPR006253 Malate_synthG
PANTHERiPTHR42739 PTHR42739, 1 hit
PfamiView protein in Pfam
PF01274 Malate_synthase, 1 hit
SUPFAMiSSF51645 SSF51645, 1 hit
TIGRFAMsiTIGR01345 malate_syn_G, 1 hit

Sequencei

Sequence statusi: Complete.

C4ISM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSAEKRNYV EIEGLAVAPE LVEFLAKEAA PGTGVEPEKF WKGFAAIIRD
60 70 80 90 100
LTPKNRALLA KRDELQARID AWYKENRDKG YSQADYQQFL KDIGYLLPEG
110 120 130 140 150
GAFSVSTTNV DPEITHIAGP QLVVPVMNAR YALNAANARW GSLYDALYGT
160 170 180 190 200
DAISEADGAE KGKGYNPKRG EKVIAWAKNF LDESAPLSTG KWADVAGLAV
210 220 230 240 250
NDGKLEIRLT DGSATTLKDE SQFKGYNGDA ASPTNVLLAK HNMHVDIVIN
260 270 280 290 300
ADHPIGKTDP AHIADVVLES AISTIQDCED SIAVVDAEDK VAVYRNWLGL
310 320 330 340 350
MNGKLEDTFE KNGKQMTRRL NGDRTYTAPD GSTLTLKGRS LMLVRNVGHL
360 370 380 390 400
MTNPAILDAE GNEVPEGIMD AAFTSLIALH DIGPNGRHMN SREGSVYIVK
410 420 430 440 450
PKMHGPEEVA FANEIFTRTE EMLGMKPNTL KIGIMDEERR TTVNLKEAIR
460 470 480 490 500
AAKDRVVFIN TGFLDRTGDE IHTSMEAGPM IRKGDMKQAA WIGAYEQWNV
510 520 530 540 550
DIGLECGLSG HAQIGKGMWA MPDMMAAMLE QKIAHPKAGA NTAWVPSPTA
560 570 580 590 600
ATLHATHYHK IDVAAVQEKL KSRPRAKLDD ILSVPVAVRP NWTPDDIQHE
610 620 630 640 650
IDNNAQGILG YVVRWIDQGV GCSKVPDINN VGLMEDRATL RISAQHIANW
660 670 680 690 700
LYHGVVSEAQ VMETMKRMAA IVDKQNEGDP LYRPMAADFD KSIAFQAACD
710 720
LVFKGREQPN GYTEPVLHRR RLELKQAS
Length:728
Mass (Da):80,044
Last modified:July 7, 2009 - v1
Checksum:iA6301C27C4FF27FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACOR01000003 Genomic DNA Translation: EEP62905.1
RefSeqiWP_002966937.1, NZ_ACOR01000003.1

Genome annotation databases

EnsemblBacteriaiEEP62905; EEP62905; BAAA_3000014

Similar proteinsi

Entry informationi

Entry nameiC4ISM0_BRUAO
AccessioniPrimary (citable) accession number: C4ISM0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 7, 2009
Last sequence update: July 7, 2009
Last modified: April 25, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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