C4GZB4 (C4GZB4_YERPE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Glyoxylate/hydroxypyruvate reductase B HAMAP MF_01667
EC=1.1.1.79 HAMAP MF_01667
EC=1.1.1.81 HAMAP MF_01667

Gene names

Name:	ghrB HAMAP MF_01667 EMBL EEO83261.1
ORF Names:	YPF_0194 EMBL EEO83261.1

Organism

Yersinia pestis biovar Orientalis str. India 195 EMBL EEO83261.1

Taxonomic identifier

547047 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively By similarity. HAMAP MF_01667
Catalytic activity	D-glycerate + NAD(P)+ = hydroxypyruvate + NAD(P)H. HAMAP MF_01667 SAAS SAAS023756 Glycolate + NADP+ = glyoxylate + NADPH. SAAS SAAS023756 HAMAP MF_01667
Subunit structure	Homodimer By similarity. HAMAP MF_01667 SAAS SAAS023756
Subcellular location	Cytoplasm By similarity SAAS SAAS023756 HAMAP MF_01667.
Sequence similarities	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily. HAMAP MF_01667

Ontologies

Keywords
Cellular component	Cytoplasm SAAS SAAS023756 HAMAP MF_01667
Ligand	NAD SAAS SAAS023756 HAMAP MF_01667 NADP SAAS SAAS023756 HAMAP MF_01667
Molecular function	Oxidoreductase SAAS SAAS023756 HAMAP MF_01667 EMBL EEO83261.1
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro glyoxylate reductase (NADP) activity Inferred from electronic annotation. Source: HAMAP hydroxypyruvate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	237	1	By similarity HAMAP MF_01667
	Active site	266	1	By similarity HAMAP MF_01667
	Active site	285	1	Proton donor By similarity HAMAP MF_01667

Sequences

	Sequence		Length	Mass (Da)
	C4GZB4 [UniParc]. Last modified July 7, 2009. Version 1. Checksum: 935B405A48250AE2	FASTA	326	35,465
	10 20 30 40 50 60 MKPSIVLYKS IPTDLHQRLA QHFTVNSFDG LTPDNQPELL AALQQAEGLI GSGGKIDQDF 70 80 90 100 110 120 LQLAPNLRAA STISVGYDNF DVEALSQRGI ALMHTPTVLT ETVADTMMAL MLSTARRVVE 130 140 150 160 170 180 LAERVKAGEW QESIGDDWFG VDVHHKTIGI LGMGRIGMAL AQRAHFGFSM PVLYTSRRPH 190 200 210 220 230 240 EAAEQRFGAR HCSLDTLLAE ADFLCITLPM TEQTYHMIGR EQLAKMKSSA ILINAGRGPV 250 260 270 280 290 300 VDEQALIAAL QDGTIHAAGL DVFEQEPLPV DSPLLTLRNV VAVPHIGSAT HETRYNMAAC 310 320 AVDNLINALT GTVKENCVNP QVLITH

References

[1]

"Yersinia pestis India 195 whole genome shotgun sequencing project." Plunkett G.III., Anderson B.D., Baumler D.J., Burland V., Cabot E.L., Glasner J.D., Mau B., Neeno-Eckwall E., Perna N.T., Munk A.C., Tapia R., Green L.D., Rogers Y.C., Detter J.C., Bruce D.C., Brettin T.S. Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: India 195 EMBL EEO83261.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	ACNR01000001 Genomic DNA. Translation: EEO83261.1.
3D structure databases
ProteinModelPortal	C4GZB4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
PATRIC	30844368. VBIYerPes43691_0200.
Phylogenomic databases
OMA	HALTEKK.
Family and domain databases
HAMAP	MF_01667. 2_Hacid_dh_C_GhrB. [Tree]
InterPro	IPR006139. D-isomer_2_OHA_DH_cat_dom. IPR006140. D-isomer_2_OHA_DH_NAD-bd. IPR023756. Glyo/OHPyrv_Rdtase_B. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 2 hits.
Pfam	PF00389. 2-Hacid_dh. 1 hit. PF02826. 2-Hacid_dh_C. 1 hit. [Graphical view]
PROSITE	PS00065. D_2_HYDROXYACID_DH_1. 1 hit. PS00671. D_2_HYDROXYACID_DH_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C4GZB4_YERPE

Accession

Primary (citable) accession number: C4GZB4

Entry history

Integrated into UniProtKB/TrEMBL:	July 7, 2009
Last sequence update:	July 7, 2009
Last modified:	December 14, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)