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C4A0D9

- BAP1_BRAFL

UniProt

C4A0D9 - BAP1_BRAFL

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Protein

Ubiquitin carboxyl-terminal hydrolase BAP1

Gene

BAP1

Organism
Branchiostoma floridae (Florida lancelet) (Amphioxus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei91 – 911NucleophileBy similarity
Active sitei169 – 1691Proton donorBy similarity
Sitei184 – 1841Important for enzyme activityBy similarity

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. ubiquitin-specific protease activity Source: UniProtKB
  3. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. monoubiquitinated histone H2A deubiquitination Source: UniProtKB
  2. protein deubiquitination Source: UniProtKB
  3. protein K48-linked deubiquitination Source: UniProtKB
  4. regulation of cell cycle Source: UniProtKB
  5. regulation of cell growth Source: UniProtKB
  6. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC12.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase BAP1 (EC:3.4.19.12)
Alternative name(s):
BRCA1-associated protein 1
Gene namesi
Name:BAP1
ORF Names:BRAFLDRAFT_277645
OrganismiBranchiostoma floridae (Florida lancelet) (Amphioxus)
Taxonomic identifieri7739 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma
ProteomesiUP000001554: Partially assembled WGS sequence

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Mainly nuclear. Binds to chromatin (By similarity).By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
  3. PR-DUB complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 694694Ubiquitin carboxyl-terminal hydrolase BAP1PRO_0000395822Add
BLAST

Interactioni

Subunit structurei

Component of the PR-DUB complex.By similarity

Protein-protein interaction databases

STRINGi7739.JGI277645.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C12 family. BAP1 subfamily.Curated

Phylogenomic databases

eggNOGiNOG249036.
InParanoidiC4A0D9.
KOiK08588.
OMAiSERIGNA.

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERiPTHR10589. PTHR10589. 1 hit.
PfamiPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSiPR00707. UBCTHYDRLASE.

Sequencei

Sequence statusi: Complete.

C4A0D9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLSKPIE GPVYGFIFLF
60 70 80 90 100
KWSEERRSRR KVGPSMEESF VVDEDIVNDM FFAQQLIPNS CATHALLSVL
110 120 130 140 150
LNCPQISLGS TLTRLKYFTR GMGPESKGWA IGNVPEIARA HNSHARPEPR
160 170 180 190 200
HLPEKQTGIS SVRTAEAFHF VSYVTTNDRL FELDGLKPYP IDHGPWGEKE
210 220 230 240 250
DWTEKFRRVI SERIGNATGG ENGHDIRFNL MAVVADRRQQ YETKLNTLKT
260 270 280 290 300
NRQIVLEALQ QVGGVNTKKS IQYAEVSHVC LHPPKFVPCS DDCAIWDALR
310 320 330 340 350
YSSALRCSLI QHGCEHPSIP RSDGSTLVSW PSCVTSVNIV VSGHLKYVLL
360 370 380 390 400
CFSIILDHKL EKLVPARLDP IKVNEPHLTS LIPSAFGRES HHKSKASSTV
410 420 430 440 450
TSSSAAASSS AAGTDGVQPA EMKPDEFLHP DASRRVGFLE MPWRSDEARP
460 470 480 490 500
LSIHTGYSKI PSPAPSNEST DTASEIGSAF NSPVRSANRS ALQTIPEGSI
510 520 530 540 550
TKQEGDTKTD ANIITVCLKR SLSGEGGGPP AKRLHIGDPD MALQRLGSGD
560 570 580 590 600
SVEGDPMALQ GGSGTGDAQQ DQHALQAGGA RPNMAHAFAP KDLLALLKNV
610 620 630 640 650
ETEIQICEQH LKDEIEKRKK YKVDDCRRTH NYDDFIRTFL RMLAEQGQLS
660 670 680 690
KLVDQHVLVR RRQGVSVGRL HKQRKPDRRR KRARVSDKYR RKKQ
Length:694
Mass (Da):77,164
Last modified:July 28, 2009 - v1
Checksum:i6A4B1902DE067B3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG666800 Genomic DNA. Translation: EEN41742.1.
RefSeqiXP_002585731.1. XM_002585685.1.

Genome annotation databases

GeneIDi7222775.
KEGGibfo:BRAFLDRAFT_277645.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG666800 Genomic DNA. Translation: EEN41742.1 .
RefSeqi XP_002585731.1. XM_002585685.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7739.JGI277645.

Protein family/group databases

MEROPSi C12.004.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 7222775.
KEGGi bfo:BRAFLDRAFT_277645.

Phylogenomic databases

eggNOGi NOG249036.
InParanoidi C4A0D9.
KOi K08588.
OMAi SERIGNA.

Family and domain databases

Gene3Di 3.40.532.10. 1 hit.
InterProi IPR001578. Peptidase_C12_UCH.
[Graphical view ]
PANTHERi PTHR10589. PTHR10589. 1 hit.
Pfami PF01088. Peptidase_C12. 1 hit.
[Graphical view ]
PRINTSi PR00707. UBCTHYDRLASE.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S238N-H82.
    Tissue: Testis.

Entry informationi

Entry nameiBAP1_BRAFL
AccessioniPrimary (citable) accession number: C4A0D9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 28, 2009
Last modified: October 29, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3