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C4A0D9

- BAP1_BRAFL

UniProt

C4A0D9 - BAP1_BRAFL

Protein

Ubiquitin carboxyl-terminal hydrolase BAP1

Gene

BAP1

Organism
Branchiostoma floridae (Florida lancelet) (Amphioxus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei91 – 911NucleophileBy similarity
    Active sitei169 – 1691Proton donorBy similarity
    Sitei184 – 1841Important for enzyme activityBy similarity

    GO - Molecular functioni

    1. chromatin binding Source: UniProtKB
    2. ubiquitin-specific protease activity Source: UniProtKB
    3. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. monoubiquitinated histone H2A deubiquitination Source: UniProtKB
    2. protein deubiquitination Source: UniProtKB
    3. protein K48-linked deubiquitination Source: UniProtKB
    4. regulation of cell cycle Source: UniProtKB
    5. regulation of cell growth Source: UniProtKB
    6. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC12.004.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase BAP1 (EC:3.4.19.12)
    Alternative name(s):
    BRCA1-associated protein 1
    Gene namesi
    Name:BAP1
    ORF Names:BRAFLDRAFT_277645
    OrganismiBranchiostoma floridae (Florida lancelet) (Amphioxus)
    Taxonomic identifieri7739 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma
    ProteomesiUP000001554: Partially assembled WGS sequence

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity
    Note: Mainly nuclear. Binds to chromatin By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB
    3. PR-DUB complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 694694Ubiquitin carboxyl-terminal hydrolase BAP1PRO_0000395822Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the PR-DUB complex.By similarity

    Protein-protein interaction databases

    STRINGi7739.JGI277645.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C12 family. BAP1 subfamily.Curated

    Phylogenomic databases

    eggNOGiNOG249036.
    KOiK08588.
    OMAiSERIGNA.

    Family and domain databases

    Gene3Di3.40.532.10. 1 hit.
    InterProiIPR001578. Peptidase_C12_UCH.
    [Graphical view]
    PANTHERiPTHR10589. PTHR10589. 1 hit.
    PfamiPF01088. Peptidase_C12. 1 hit.
    [Graphical view]
    PRINTSiPR00707. UBCTHYDRLASE.

    Sequencei

    Sequence statusi: Complete.

    C4A0D9-1 [UniParc]FASTAAdd to Basket

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    MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLSKPIE GPVYGFIFLF    50
    KWSEERRSRR KVGPSMEESF VVDEDIVNDM FFAQQLIPNS CATHALLSVL 100
    LNCPQISLGS TLTRLKYFTR GMGPESKGWA IGNVPEIARA HNSHARPEPR 150
    HLPEKQTGIS SVRTAEAFHF VSYVTTNDRL FELDGLKPYP IDHGPWGEKE 200
    DWTEKFRRVI SERIGNATGG ENGHDIRFNL MAVVADRRQQ YETKLNTLKT 250
    NRQIVLEALQ QVGGVNTKKS IQYAEVSHVC LHPPKFVPCS DDCAIWDALR 300
    YSSALRCSLI QHGCEHPSIP RSDGSTLVSW PSCVTSVNIV VSGHLKYVLL 350
    CFSIILDHKL EKLVPARLDP IKVNEPHLTS LIPSAFGRES HHKSKASSTV 400
    TSSSAAASSS AAGTDGVQPA EMKPDEFLHP DASRRVGFLE MPWRSDEARP 450
    LSIHTGYSKI PSPAPSNEST DTASEIGSAF NSPVRSANRS ALQTIPEGSI 500
    TKQEGDTKTD ANIITVCLKR SLSGEGGGPP AKRLHIGDPD MALQRLGSGD 550
    SVEGDPMALQ GGSGTGDAQQ DQHALQAGGA RPNMAHAFAP KDLLALLKNV 600
    ETEIQICEQH LKDEIEKRKK YKVDDCRRTH NYDDFIRTFL RMLAEQGQLS 650
    KLVDQHVLVR RRQGVSVGRL HKQRKPDRRR KRARVSDKYR RKKQ 694
    Length:694
    Mass (Da):77,164
    Last modified:July 28, 2009 - v1
    Checksum:i6A4B1902DE067B3D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG666800 Genomic DNA. Translation: EEN41742.1.
    RefSeqiXP_002585731.1. XM_002585685.1.

    Genome annotation databases

    GeneIDi7222775.
    KEGGibfo:BRAFLDRAFT_277645.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG666800 Genomic DNA. Translation: EEN41742.1 .
    RefSeqi XP_002585731.1. XM_002585685.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7739.JGI277645.

    Protein family/group databases

    MEROPSi C12.004.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 7222775.
    KEGGi bfo:BRAFLDRAFT_277645.

    Phylogenomic databases

    eggNOGi NOG249036.
    KOi K08588.
    OMAi SERIGNA.

    Family and domain databases

    Gene3Di 3.40.532.10. 1 hit.
    InterProi IPR001578. Peptidase_C12_UCH.
    [Graphical view ]
    PANTHERi PTHR10589. PTHR10589. 1 hit.
    Pfami PF01088. Peptidase_C12. 1 hit.
    [Graphical view ]
    PRINTSi PR00707. UBCTHYDRLASE.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: S238N-H82.
      Tissue: Testis.

    Entry informationi

    Entry nameiBAP1_BRAFL
    AccessioniPrimary (citable) accession number: C4A0D9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3