Skip Header

Contribute Send feedback
Read comments (?) or add your own

C4A0D9 (BAP1_BRAFL) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase BAP1
EC=3.4.19.12
Alternative name(s):
BRCA1-associated protein 1
Gene names
Name:BAP1
ORF Names:BRAFLDRAFT_277645
OrganismBranchiostoma floridae (Florida lancelet) (Amphioxus) [Reference proteome]
Taxonomic identifier7739 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Cephalochordata › Branchiostomidae › Branchiostoma

Protein attributes

Sequence length694 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Component of the PR-DUB complex By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Note: Mainly nuclear. Binds to chromatin By similarity.

Sequence similarities

Belongs to the peptidase C12 family. BAP1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 694694Ubiquitin carboxyl-terminal hydrolase BAP1
PRO_0000395822

Sites

Active site911Nucleophile By similarity
Active site1691Proton donor By similarity
Site1841Important for enzyme activity By similarity

Sequences

Sequence LengthMass (Da)Tools
C4A0D9 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 6A4B1902DE067B3D

FASTA69477,164
        10         20         30         40         50         60 
MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLSKPIE GPVYGFIFLF KWSEERRSRR 

        70         80         90        100        110        120 
KVGPSMEESF VVDEDIVNDM FFAQQLIPNS CATHALLSVL LNCPQISLGS TLTRLKYFTR 

       130        140        150        160        170        180 
GMGPESKGWA IGNVPEIARA HNSHARPEPR HLPEKQTGIS SVRTAEAFHF VSYVTTNDRL 

       190        200        210        220        230        240 
FELDGLKPYP IDHGPWGEKE DWTEKFRRVI SERIGNATGG ENGHDIRFNL MAVVADRRQQ 

       250        260        270        280        290        300 
YETKLNTLKT NRQIVLEALQ QVGGVNTKKS IQYAEVSHVC LHPPKFVPCS DDCAIWDALR 

       310        320        330        340        350        360 
YSSALRCSLI QHGCEHPSIP RSDGSTLVSW PSCVTSVNIV VSGHLKYVLL CFSIILDHKL 

       370        380        390        400        410        420 
EKLVPARLDP IKVNEPHLTS LIPSAFGRES HHKSKASSTV TSSSAAASSS AAGTDGVQPA 

       430        440        450        460        470        480 
EMKPDEFLHP DASRRVGFLE MPWRSDEARP LSIHTGYSKI PSPAPSNEST DTASEIGSAF 

       490        500        510        520        530        540 
NSPVRSANRS ALQTIPEGSI TKQEGDTKTD ANIITVCLKR SLSGEGGGPP AKRLHIGDPD 

       550        560        570        580        590        600 
MALQRLGSGD SVEGDPMALQ GGSGTGDAQQ DQHALQAGGA RPNMAHAFAP KDLLALLKNV 

       610        620        630        640        650        660 
ETEIQICEQH LKDEIEKRKK YKVDDCRRTH NYDDFIRTFL RMLAEQGQLS KLVDQHVLVR 

       670        680        690 
RRQGVSVGRL HKQRKPDRRR KRARVSDKYR RKKQ

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		GG666800 Genomic DNA. Translation: EEN41742.1.
RefSeqXP_002585731.1. XM_002585685.1.

3D structure databases

ModBaseSearch...

Protein family/group databases

MEROPSC12.004.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7222775.
KEGGbfo:BRAFLDRAFT_277645.

Phylogenomic databases

eggNOGNOG249036.
KOK08588.
OMASERIGNA.

Family and domain databases

Gene3D3.40.532.10. 1 hit.
InterProIPR001578. Peptidase_C12.
[Graphical view]
PANTHERPTHR10589. PTHR10589. 1 hit.
PfamPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSPR00707. UBCTHYDRLASE.
PROSITEPS00140. UCH_1. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBAP1_BRAFL
AccessionPrimary (citable) accession number: C4A0D9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 28, 2009
Last modified: March 6, 2013
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents