ID   C3ZV58_BRAFL            Unreviewed;       483 AA.
AC   C3ZV58;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   24-JAN-2024, entry version 71.
DE   RecName: Full=Aldehyde dehydrogenase domain-containing protein {ECO:0000259|Pfam:PF00171};
DE   Flags: Fragment;
GN   ORFNames=BRAFLDRAFT_230530 {ECO:0000313|EMBL:EEN43593.1};
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomatidae; Branchiostoma.
OX   NCBI_TaxID=7739;
RN   [1] {ECO:0000313|EMBL:EEN43593.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN43593.1};
RC   TISSUE=Testes {ECO:0000313|EMBL:EEN43593.1};
RX   PubMed=18563158; DOI=10.1038/nature06967;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA   Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA   Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA   Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA   Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA   Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA   Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA   Satoh N., Rokhsar D.S.;
RT   "The amphioxus genome and the evolution of the chordate karyotype.";
RL   Nature 453:1064-1071(2008).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|RuleBase:RU003345}.
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DR   EMBL; GG666687; EEN43593.1; -; Genomic_DNA.
DR   RefSeq; XP_002587582.1; XM_002587536.1.
DR   AlphaFoldDB; C3ZV58; -.
DR   STRING; 7739.C3ZV58; -.
DR   eggNOG; KOG2456; Eukaryota.
DR   InParanoid; C3ZV58; -.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IBA:GO_Central.
DR   GO; GO:0006081; P:cellular aldehyde metabolic process; IBA:GO_Central.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR012394; Aldehyde_DH_NAD(P).
DR   PANTHER; PTHR43570; ALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR43570:SF16; ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PIRSF; PIRSF036492; ALDH; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003345};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        464..482
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          17..426
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        206
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036492-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU10007"
FT   ACT_SITE        240
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036492-1"
FT   NON_TER         483
FT                   /evidence="ECO:0000313|EMBL:EEN43593.1"
SQ   SEQUENCE   483 AA;  54262 MW;  435A941C0FEE538C CRC64;
     MTAIVQHLRE NVGKMRSVEY RREQLRALLR CIDENLDRWI EVLRKDLHKV GYAFEYMSLR
     TVNELIVHLN NLDEWTKPEY VKKELPQMRD ECYIQYEPLG VILVIGAWNY PVQLVLCPLI
     AAISAGNCAV VKPSELSEAT AALVEDLLPK YLDKAMDCFA VVNGGVKETT ELLEQKFDHI
     MYTGNSNVGR IVMAAAAKHL TPVTLELGGK SPCYVDKDCD VDVAARRIAW GRFVNCGQTC
     IAPDYVLCAS QNQDRLLKGI QAALEEYFGK DPRQSEDYCR IVNQRHFHRV KSMIEKTKGS
     IALGGDSDEK DLYISPTVVK DVKPTDALME AEIFGPVLPI VTAESADDAV RFINSRDKPL
     ALYAFANDKK VIHDIVQRTS SGSVCGNDTM MQMALPTLPF GGVGTSGMGN YHGKFGFLTF
     SHRKAVMVKA LAMEKVNSIR YPPYTEKKMS WINWLTNKKE KRRGGLFSFM PFAVIMTILA
     VLL
//