ID   C3ZIP4_BRAFL            Unreviewed;      1088 AA.
AC   C3ZIP4;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 69.
DE   RecName: Full=Lactase {ECO:0008006|Google:ProtNLM};
GN   Name=SUFU {ECO:0000313|EMBL:EEN47579.1};
GN   ORFNames=BRAFLDRAFT_105101 {ECO:0000313|EMBL:EEN47579.1};
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomatidae; Branchiostoma.
OX   NCBI_TaxID=7739 {ECO:0000313|EMBL:EEN47579.1};
RN   [1] {ECO:0000313|EMBL:EEN47579.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN47579.1};
RC   TISSUE=Testes {ECO:0000313|EMBL:EEN47579.1};
RX   PubMed=18563158; DOI=10.1038/nature06967;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA   Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA   Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA   Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA   Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA   Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA   Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA   Satoh N., Rokhsar D.S.;
RT   "The amphioxus genome and the evolution of the chordate karyotype.";
RL   Nature 453:1064-1071(2008).
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DR   EMBL; GG666628; EEN47579.1; -; Genomic_DNA.
DR   RefSeq; XP_002591568.1; XM_002591522.1.
DR   AlphaFoldDB; C3ZIP4; -.
DR   eggNOG; KOG0626; Eukaryota.
DR   InParanoid; C3ZIP4; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008422; F:beta-glucosidase activity; IBA:GO_Central.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.80; Glycosidases; 2.
DR   InterPro; IPR001360; Glyco_hydro_1.
DR   InterPro; IPR018120; Glyco_hydro_1_AS.
DR   InterPro; IPR033132; Glyco_hydro_1_N_CS.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR10353; GLYCOSYL HYDROLASE; 1.
DR   PANTHER; PTHR10353:SF36; KLOTHO (MAMMALIAN AGING-ASSOCIATED PROTEIN) HOMOLOG; 1.
DR   Pfam; PF00232; Glyco_hydro_1; 2.
DR   PRINTS; PR00131; GLHYDRLASE1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 2.
DR   PROSITE; PS00572; GLYCOSYL_HYDROL_F1_1; 2.
DR   PROSITE; PS00653; GLYCOSYL_HYDROL_F1_2; 2.
PE   4: Predicted;
KW   Glycosidase {ECO:0000256|RuleBase:RU004468};
KW   Hydrolase {ECO:0000256|RuleBase:RU004468};
KW   Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           17..1088
FT                   /note="Lactase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002936843"
FT   TRANSMEM        1070..1087
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   ACT_SITE        410
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10055"
FT   ACT_SITE        948
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10055"
SQ   SEQUENCE   1088 AA;  123465 MW;  2EFFAD2DAE85C1EF CRC64;
     MLSLLTTSLL LGFTCGAVYD YGAYNRTRDN FRPGTFPDDF IWSTATASYQ IEGAWNVDGK
     GESIWDRFSH TPGKVDRGDT GDVACDSYNK YREDVQLMKA MGLKYYRFSL SWPRIFPDGT
     VAGGVNQAGV DYYNNVIDEL LANGITPMVT LYHWDLPQAL QDRYGGWVNE ELVRHFNDYA
     DFVFQTFGDR VTYWITFNEP WVVCFLGYGT GGNAPGIQDS GNSTYLCGHT ILKAHAEAWH
     TYDTTYRRSQ QGQISITLNC DWPEPRDPDS PADVAAADRY IQFYIGWFAH PIYSAAGDYP
     AAMKDIIREK SLAEGLQESR LPQFTPAEID RIKGTGDFFG LNHYTARIIQ NRVDPTDTPG
     YSNDRNLSES TAPEWPRAAS EWLYVVPWGL RRLLKFIKLN YGDPDVFITE NGRSDHDEQP
     PVMEDADRIC YYMGYIDEVL KAIEVDGVKV RAYTAWSLMD NFEWSRGYTE RFGLHYVNFT
     DPRRPRVPKE SAGFYSDIIA NNGFPEGADV TTMVRSRLLQ SYLGTAGLTR VLVKMSGTML
     GLFATSLLLG LVWGAEYNYG AYDHSRDAFR PGRFPDGFIW STATASYQIE GGWEADGKGE
     SIWDRFSHTP GKVDRGDTGD VACDSYNKYR EDVQLMTDLG LKYYRFSLSW TRIFPDGTLA
     SGPNEAGVAY YNNLIDELVR NGVTPMVTLY HWDLPQNLQD TYGGWVSQGI VKHFNDYATF
     AFQTFGDRVR YWITFNEPWV VCYIGYGTGE HAPGIQDERN STYLCGHNIL KAHANAWHTY
     DTGFRQSQGG QVGITLNSDW AEPRDPDLDA DVIATDRYLQ FYLGWFANPI YSVGGDYPVV
     MKEAVLAKSQ AEGLRESRLP QFTQEEVEYI RGTSDFFGLN HYTTRIIADN VVVGAAPGYA
     NDRDIAQYTA PEWSRAESEW LYEVPWGLRR LLNFIKLNYG DPEVLVTENG RSDGDVTPPL
     MVDTCRICYY MTYIDEVLKA IDLDGVKVRA YTAWSLMDNF EWARGYTERF GLHYVDFNDL
     NRPRTPKESA GFFKDVIANN GFPEGADVTR MVQDMWRDCR GAGAKSHADI ALLALAFIIT
     AMYNLVYM
//