C3ZBK6 (C3ZBK6_BRAFL) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Adenosylhomocysteinase RuleBase RU000548
EC=3.3.1.1 RuleBase RU000548

Gene names

ORF Names:

BRAFLDRAFT_113595 EMBL EEN50243.1

Organism

Branchiostoma floridae (Florida lancelet) (Amphioxus)

Taxonomic identifier

7739 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Cephalochordata › Branchiostomidae › Branchiostoma

Protein attributes

Sequence length	434 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. RuleBase RU000548
Cofactor	NAD By similarity. RuleBase RU000548
Pathway	Amino-acid biosynthesis; homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. RuleBase RU000548
Sequence similarities	Belongs to the adenosylhomocysteinase family. RuleBase RU004166

Ontologies

Keywords
Biological process	One-carbon metabolism RuleBase RU000548
Ligand	NAD RuleBase RU000548
Molecular function	Hydrolase RuleBase RU000548
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	adenosylhomocysteinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Binding site	59	1	Substrate By similarity PIRSR PIRSR001109-1
	Binding site	134	1	Substrate By similarity PIRSR PIRSR001109-1
	Binding site	159	1	Substrate By similarity PIRSR PIRSR001109-1
	Binding site	189	1	Substrate By similarity PIRSR PIRSR001109-1
	Binding site	193	1	Substrate By similarity PIRSR PIRSR001109-1

Sequences

	Sequence		Length	Mass (Da)
	C3ZBK6 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: 6F41B77CFBF74B5D	FASTA	434	47,908
	10 20 30 40 50 60 MGSEKKLPYK VADLSLAEFG RKEIELAERE MPGLMMMRAK YGKDKPLKGA RIAGCLHMTI 70 80 90 100 110 120 QTAVLIETLK ELGAEVTWSS CNIFSTQDHA AAAMAKAGVP VYAWKGETDE EYMWCVEQTI 130 140 150 160 170 180 YFPDGQPLNM ILDDGGDLTN LVHTKYPQLL EGIKGLSEET TTGVHNLYKM MAKGDLKCPA 190 200 210 220 230 240 INVNDSVTKS KFDNLYGCRE SLVDGIKRAT DIMLAGKVAV VAGYGDVGKG SAQSLKAFGA 250 260 270 280 290 300 RVLITEIDPI NALQAAMEGY QVTTMDEACK EGNIFVTATG CKDIIKAEHF QQMKEDAIVC 310 320 330 340 350 360 NIGHFDCELE VKWLNDNAKK DSIKPQVDRY TLPSGRHIIL LAEGRLVNLG CATGHPSFVM 370 380 390 400 410 420 SNSFTNQVLA QIELWTKPDQ YKVGVFVLPK KLDEEVAEAH LEQLGVKLTR LSDDQAGYLG 430 IPKEGPYKPD FYRY

References

[1]

"The amphioxus genome and the evolution of the chordate karyotype." US DOE Joint Genome Institute (JGI-PGF) Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U., Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K., Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J., Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J. , Kapitonov V.V., Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A., Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T., Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H., Satoh N., Rokhsar D.S. Nature 453:1064-1071(2008) [PubMed: 18563158] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: S238N-H82 EMBL EEN50243.1. Tissue: Testes EMBL EEN50243.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GG666603 Genomic DNA. Translation: EEN50243.1.
RefSeq	XP_002594232.1. XM_002594186.1.
UniGene	Bfl.2076.
3D structure databases
ProteinModelPortal	C3ZBK6.
ModBase	Search...
Protein-protein interaction databases
STRING	C3ZBK6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7212325.
KEGG	bfo:BRAFLDRAFT_113595.
Phylogenomic databases
OMA	MKEDAIV.
PhylomeDB	C3ZBK6.
Family and domain databases
HAMAP	MF_00563. AdoHcyase. [Tree]
InterPro	IPR000043. Adenosylhomocysteinase. IPR015878. Ado_hCys_hydrolase_NAD-bd. IPR020082. S-Ado-L-homoCys_hydrolase_CS. [Graphical view]
KO	K01251.
PANTHER	PTHR23420. Ad_hcy_hydrolase. 1 hit.
Pfam	PF05221. AdoHcyase. 1 hit. PF00670. AdoHcyase_NAD. 1 hit. [Graphical view]
PIRSF	PIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMART	SM00996. AdoHcyase. 1 hit. SM00997. AdoHcyase_NAD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00936. AhcY. 1 hit.
PROSITE	PS00738. ADOHCYASE_1. 1 hit. PS00739. ADOHCYASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C3ZBK6_BRAFL

Accession

Primary (citable) accession number: C3ZBK6

Entry history

Integrated into UniProtKB/TrEMBL:	July 28, 2009
Last sequence update:	July 28, 2009
Last modified:	January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)