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Protein

DNA ligase

Gene

BRAFLDRAFT_69217

Organism
Branchiostoma floridae (Florida lancelet) (Amphioxus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:BRAFLDRAFT_69217Imported
OrganismiBranchiostoma floridae (Florida lancelet) (Amphioxus)Imported
Taxonomic identifieri7739 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma
ProteomesiUP000001554 Componenti: Partially assembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi7739.JGI69217.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
InParanoidiC3Z7P4.
KOiK10747.
OMAiCHIVISK.

Family and domain databases

Gene3Di1.10.3260.10. 2 hits.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3Z7P4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQRSISSFF APRAKTPKQD TAATGHKSPL KTKNGSPPAF APGDDSPVKS
60 70 80 90 100
LPRKKKARRI IDSDDDDEDE EENVAMEIEP SKSADEQKEA KDVEKTPKEV
110 120 130 140 150
EKVKDESEDV PSPKMPRVTY NGPNLQSPGG IPKRKTARKQ LPTPKRKLVE
160 170 180 190 200
IKSPKSNGHT SPTAEEEESS AKKVKTEKKE EKEEKTEEKM EEDSPDEEVK
210 220 230 240 250
EKVKDEEEVV QQNKKKKSPK PKKEKQSPKS VDKKKKIKEE PGEKAKESAG
260 270 280 290 300
PSEDSMDSLF AAVIRKAGEA TAEEEKEETE EKKEKSTEDL KSPSDKKAVK
310 320 330 340 350
KEEDSSKKSS SGISSFFSPK RSSQPTDESS EKKPSPKPAA KPMAAFFKPK
360 370 380 390 400
QEADKTVPYL ALAKTFEAIE EVRARLKITE ILCNFFRSVI ALTPDDLVQC
410 420 430 440 450
VYLCLNKVGP AYEGLELGIG ETVLMKAIAE ATGRKMAQIK TDAQEKGDLG
460 470 480 490 500
IVAEVMTKKI NFIKGMFVAC RQSEARYLIR SLGGKLRIGL AEQSVLTALA
510 520 530 540 550
HAATLTPAGK DVLDAGKGKS SDALKKKLED AALILKTTYC EMPNYDAVIS
560 570 580 590 600
AMLKHGLEEL PKHCKLTPGT PLKPMLAHPT KGVSEVLRRF EGAEFTCEYK
610 620 630 640 650
YDGERAQIHM LENGEIHIYS RNQENNTSKY PDIIERMPKV NHDDVTSCII
660 670 680 690 700
DSEAVAWDPE NKKILPFQVL STRKRKDADQ SEIKVQVCVY AFDLLYLNGQ
710 720 730 740 750
SLVREPFRKR REMLRESFNE VEGEFVFATS MVSGNTEEIA VFLDASIKDS
760 770 780 790 800
CEGLMVKTLD KDATYEIAKR SHNWLKLKKD YLDGVGDTLD VVPIGGFLGT
810 820 830 840 850
GKRTGKYGGF LLACYSEEDE EFQSICKIGT GFKDEELEQH TEFFKNHVVD
860 870 880 890 900
KPKSYYRYDS SVEPDHWFDA VQVWEIKCAD LSISPVHKAA EGIVDPEKGI
910 920 930 940 950
SLRFPRFLRI RDDKKPEEAT SAQQVAEMYR NQDQVKNQQS NEKSEPADDD

FY
Length:952
Mass (Da):106,658
Last modified:July 28, 2009 - v1
Checksum:iF0778CE028E3CAF7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG666591 Genomic DNA. Translation: EEN51399.1.
RefSeqiXP_002595387.1. XM_002595341.1.
UniGeneiBfl.7211.

Genome annotation databases

GeneIDi7228935.
KEGGibfo:BRAFLDRAFT_69217.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG666591 Genomic DNA. Translation: EEN51399.1.
RefSeqiXP_002595387.1. XM_002595341.1.
UniGeneiBfl.7211.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7739.JGI69217.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi7228935.
KEGGibfo:BRAFLDRAFT_69217.

Phylogenomic databases

eggNOGiCOG1793.
InParanoidiC3Z7P4.
KOiK10747.
OMAiCHIVISK.

Family and domain databases

Gene3Di1.10.3260.10. 2 hits.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S238N-H82Imported.
    Tissue: TestesImported.

Entry informationi

Entry nameiC3Z7P4_BRAFL
AccessioniPrimary (citable) accession number: C3Z7P4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: February 4, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.