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C3Z724

- UBE2S_BRAFL

UniProt

C3Z724 - UBE2S_BRAFL

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Protein

Ubiquitin-conjugating enzyme E2 S

Gene
BRAFLDRAFT_259979
Organism
Branchiostoma floridae (Florida lancelet) (Amphioxus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating polyubiquitin chains initiated by the E2 enzyme UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit By similarity.

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei97 – 971Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. activation of anaphase-promoting complex activity Source: UniProtKB
  2. anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
  3. exit from mitosis Source: UniProtKB
  4. free ubiquitin chain polymerization Source: UniProtKB
  5. protein K11-linked ubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 S (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein S
Ubiquitin-protein ligase S
Gene namesi
ORF Names:BRAFLDRAFT_259979
OrganismiBranchiostoma floridae (Florida lancelet) (Amphioxus)
Taxonomic identifieri7739 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma
ProteomesiUP000001554: Partially assembled WGS sequence

Subcellular locationi

GO - Cellular componenti

  1. anaphase-promoting complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213Ubiquitin-conjugating enzyme E2 SPRO_0000390435Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7739.JGI270270.

Structurei

3D structure databases

ProteinModelPortaliC3Z724.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5078.
KOiK10583.
OMAiQICADIE.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3Z724-1 [UniParc]FASTAAdd to Basket

« Hide

MSGSSNVENL SPQIIRQVAK EVLDLANHPP EGVKVFPNEQ DITDVQATIE    50
GPGGTPYEGG QFKIKLSLGK DFPQTPPKGF FLTKIFHPNV AKNGEICVNT 100
LKKDWKADLG LKHILLTIKC LLIYPNPESA LNEEAGKLLL EQYDNYSERA 150
RMMTEIHAKP TTKTAPTKNE ETNCPSTSGT QSTSEGPMAK KHAGDKNAAE 200
KKKKEKKRAL RRL 213
Length:213
Mass (Da):23,522
Last modified:July 28, 2009 - v1
Checksum:i0729D63B1B091D5D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG666590 Genomic DNA. Translation: EEN51620.1.
RefSeqiXP_002595608.1. XM_002595562.1.
UniGeneiBfl.10563.

Genome annotation databases

GeneIDi7216644.
KEGGibfo:BRAFLDRAFT_259979.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG666590 Genomic DNA. Translation: EEN51620.1 .
RefSeqi XP_002595608.1. XM_002595562.1.
UniGenei Bfl.10563.

3D structure databases

ProteinModelPortali C3Z724.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7739.JGI270270.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 7216644.
KEGGi bfo:BRAFLDRAFT_259979.

Phylogenomic databases

eggNOGi COG5078.
KOi K10583.
OMAi QICADIE.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S238N-H82.
    Tissue: Testis.

Entry informationi

Entry nameiUBE2S_BRAFL
AccessioniPrimary (citable) accession number: C3Z724
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: July 28, 2009
Last modified: September 3, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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