Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

C3Z724

- UBE2S_BRAFL

UniProt

C3Z724 - UBE2S_BRAFL

Protein

Ubiquitin-conjugating enzyme E2 S

Gene

BRAFLDRAFT_259979

Organism
Branchiostoma floridae (Florida lancelet) (Amphioxus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating polyubiquitin chains initiated by the E2 enzyme UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit By similarity.PROSITE-ProRule annotation

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei97 – 971Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. activation of anaphase-promoting complex activity Source: UniProtKB
    2. anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
    3. exit from mitosis Source: UniProtKB
    4. free ubiquitin chain polymerization Source: UniProtKB
    5. protein K11-linked ubiquitination Source: UniProtKB

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-conjugating enzyme E2 S (EC:6.3.2.19)
    Alternative name(s):
    Ubiquitin carrier protein S
    Ubiquitin-protein ligase S
    Gene namesi
    ORF Names:BRAFLDRAFT_259979
    OrganismiBranchiostoma floridae (Florida lancelet) (Amphioxus)
    Taxonomic identifieri7739 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma
    ProteomesiUP000001554: Partially assembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. anaphase-promoting complex Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 213213Ubiquitin-conjugating enzyme E2 SPRO_0000390435Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi7739.JGI270270.

    Structurei

    3D structure databases

    ProteinModelPortaliC3Z724.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5078.
    KOiK10583.
    OMAiQICADIE.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C3Z724-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGSSNVENL SPQIIRQVAK EVLDLANHPP EGVKVFPNEQ DITDVQATIE    50
    GPGGTPYEGG QFKIKLSLGK DFPQTPPKGF FLTKIFHPNV AKNGEICVNT 100
    LKKDWKADLG LKHILLTIKC LLIYPNPESA LNEEAGKLLL EQYDNYSERA 150
    RMMTEIHAKP TTKTAPTKNE ETNCPSTSGT QSTSEGPMAK KHAGDKNAAE 200
    KKKKEKKRAL RRL 213
    Length:213
    Mass (Da):23,522
    Last modified:July 28, 2009 - v1
    Checksum:i0729D63B1B091D5D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG666590 Genomic DNA. Translation: EEN51620.1.
    RefSeqiXP_002595608.1. XM_002595562.1.
    UniGeneiBfl.10563.

    Genome annotation databases

    GeneIDi7216644.
    KEGGibfo:BRAFLDRAFT_259979.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG666590 Genomic DNA. Translation: EEN51620.1 .
    RefSeqi XP_002595608.1. XM_002595562.1.
    UniGenei Bfl.10563.

    3D structure databases

    ProteinModelPortali C3Z724.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7739.JGI270270.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 7216644.
    KEGGi bfo:BRAFLDRAFT_259979.

    Phylogenomic databases

    eggNOGi COG5078.
    KOi K10583.
    OMAi QICADIE.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: S238N-H82.
      Tissue: Testis.

    Entry informationi

    Entry nameiUBE2S_BRAFL
    AccessioniPrimary (citable) accession number: C3Z724
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3