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C3Z724 (UBE2S_BRAFL) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-conjugating enzyme E2 S

EC=6.3.2.19
Alternative name(s):
Ubiquitin carrier protein S
Ubiquitin-protein ligase S
Gene names
ORF Names:BRAFLDRAFT_259979
OrganismBranchiostoma floridae (Florida lancelet) (Amphioxus) [Reference proteome]
Taxonomic identifier7739 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma

Protein attributes

Sequence length213 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating polyubiquitin chains initiated by the E2 enzyme UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 213213Ubiquitin-conjugating enzyme E2 S
PRO_0000390435

Sites

Active site971Glycyl thioester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
C3Z724 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 0729D63B1B091D5D

FASTA21323,522
        10         20         30         40         50         60 
MSGSSNVENL SPQIIRQVAK EVLDLANHPP EGVKVFPNEQ DITDVQATIE GPGGTPYEGG 

        70         80         90        100        110        120 
QFKIKLSLGK DFPQTPPKGF FLTKIFHPNV AKNGEICVNT LKKDWKADLG LKHILLTIKC 

       130        140        150        160        170        180 
LLIYPNPESA LNEEAGKLLL EQYDNYSERA RMMTEIHAKP TTKTAPTKNE ETNCPSTSGT 

       190        200        210 
QSTSEGPMAK KHAGDKNAAE KKKKEKKRAL RRL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GG666590 Genomic DNA. Translation: EEN51620.1.
RefSeqXP_002595608.1. XM_002595562.1.
UniGeneBfl.10563.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7739.JGI270270.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7216644.
KEGGbfo:BRAFLDRAFT_259979.

Phylogenomic databases

eggNOGCOG5078.
KOK10583.
OMAQICADIE.

Enzyme and pathway databases

UniPathwayUPA00143.

Family and domain databases

Gene3D3.10.110.10. 1 hit.
InterProIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMSSF54495. SSF54495. 1 hit.
PROSITEPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBE2S_BRAFL
AccessionPrimary (citable) accession number: C3Z724
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: July 28, 2009
Last modified: March 19, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways