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Protein

Alpha-L-fucosidase

Gene

BRAFLDRAFT_56888

Organism
Branchiostoma floridae (Florida lancelet) (Amphioxus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.By similarity

Catalytic activityi

An alpha-L-fucoside + H2O = L-fucose + an alcohol.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-L-fucosidase (EC:3.2.1.51)
Alternative name(s):
Alpha-L-fucoside fucohydrolase
Gene namesi
ORF Names:BRAFLDRAFT_56888
OrganismiBranchiostoma floridae (Florida lancelet) (Amphioxus)
Taxonomic identifieri7739 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma
Proteomesi
  • UP000001554 Componenti: Partially assembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000040697320 – 449Alpha-L-fucosidaseAdd BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi156N-linked (GlcNAc...)Sequence analysis1
Glycosylationi224N-linked (GlcNAc...)Sequence analysis1
Glycosylationi362N-linked (GlcNAc...)Sequence analysis1
Glycosylationi375N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi7739.JGI56888.

Structurei

3D structure databases

ProteinModelPortaliC3YWU0.
SMRiC3YWU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 29 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3340. Eukaryota.
COG3669. LUCA.
InParanoidiC3YWU0.
KOiK01206.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR016286. FUC_metazoa-typ.
IPR031919. Fucosidase_C.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013780. Glyco_hydro_b.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10030. PTHR10030. 1 hit.
PfamiPF01120. Alpha_L_fucos. 1 hit.
PF16757. Fucosidase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSiPR00741. GLHYDRLASE29.
SMARTiSM00812. Alpha_L_fucos. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00385. ALPHA_L_FUCOSIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C3YWU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLLLLSLL SACFQPRYAP TWDSLDQRPL PSWYDEAKFG IFMHWGVFSV
60 70 80 90 100
PSFGSEWFWW DWKGAHDQNF IKDFMKRNYP PGFRYADFAP MFTAEWYNPL
110 120 130 140 150
QWAEVLQASG AKYVVLTSKH HEGFTNWPSK YSWNWNSVDN GPHRDLVGEL
160 170 180 190 200
AMAIRNNSDL HFGLYYSLFE WFHPLYLKDK QNKWTTQDYT KDVGLAELYE
210 220 230 240 250
LVNAYHPEVV WSDGDWEAPY TYWNSTNFLA WLYNDSPVKD TVVTNDRWGS
260 270 280 290 300
GMLCHHGGYY TCSDRYNPGV LQKHKWENCM TIDKKSWGFR REATLADYLD
310 320 330 340 350
MDDLVKILAE TVSCGGNLLM NIGPTHDGRI VPIFEERLRS MGKWLQVNGD
360 370 380 390 400
AIYATKPWRA QNDTRESGVW YTSKNDSVYA IVLDWPNSGQ LTLGVPRSSP
410 420 430 440
TTTVTMLGWA APLKWVAVSG SGITVQMPTA SSNQLPCQWA WVIRMKGVM
Length:449
Mass (Da):51,880
Last modified:April 5, 2011 - v2
Checksum:i932A818CAAF41315
GO

Sequence cautioni

The sequence EEN55334 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG666561 Genomic DNA. Translation: EEN55334.1. Sequence problems.
RefSeqiXP_002599322.1. XM_002599276.1.

Genome annotation databases

GeneIDi7207966.
KEGGibfo:BRAFLDRAFT_56888.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG666561 Genomic DNA. Translation: EEN55334.1. Sequence problems.
RefSeqiXP_002599322.1. XM_002599276.1.

3D structure databases

ProteinModelPortaliC3YWU0.
SMRiC3YWU0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7739.JGI56888.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi7207966.
KEGGibfo:BRAFLDRAFT_56888.

Phylogenomic databases

eggNOGiKOG3340. Eukaryota.
COG3669. LUCA.
InParanoidiC3YWU0.
KOiK01206.

Family and domain databases

Gene3Di2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR016286. FUC_metazoa-typ.
IPR031919. Fucosidase_C.
IPR000933. Glyco_hydro_29.
IPR018526. Glyco_hydro_29_CS.
IPR013780. Glyco_hydro_b.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10030. PTHR10030. 1 hit.
PfamiPF01120. Alpha_L_fucos. 1 hit.
PF16757. Fucosidase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSiPR00741. GLHYDRLASE29.
SMARTiSM00812. Alpha_L_fucos. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00385. ALPHA_L_FUCOSIDASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFUCO_BRAFL
AccessioniPrimary (citable) accession number: C3YWU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 2, 2016
This is version 33 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.