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C3YWU0

- FUCO_BRAFL

UniProt

C3YWU0 - FUCO_BRAFL

Protein

Alpha-L-fucosidase

Gene

BRAFLDRAFT_56888

Organism
Branchiostoma floridae (Florida lancelet) (Amphioxus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 2 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.By similarity

    Catalytic activityi

    An alpha-L-fucoside + H2O = L-fucose + an alcohol.PROSITE-ProRule annotation

    GO - Molecular functioni

    1. alpha-L-fucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fucose metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-L-fucosidase (EC:3.2.1.51)
    Alternative name(s):
    Alpha-L-fucoside fucohydrolase
    Gene namesi
    ORF Names:BRAFLDRAFT_56888
    OrganismiBranchiostoma floridae (Florida lancelet) (Amphioxus)
    Taxonomic identifieri7739 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma
    ProteomesiUP000001554: Partially assembled WGS sequence

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 449430Alpha-L-fucosidasePRO_0000406973Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi224 – 2241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi362 – 3621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi375 – 3751N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi7739.JGI56888.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 29 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3669.
    KOiK01206.

    Family and domain databases

    Gene3Di2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR016286. FUC_metazoa-typ.
    IPR013780. Glyco_hydro_13_b.
    IPR000933. Glyco_hydro_29.
    IPR018526. Glyco_hydro_29_CS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10030. PTHR10030. 1 hit.
    PfamiPF01120. Alpha_L_fucos. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
    PRINTSiPR00741. GLHYDRLASE29.
    SMARTiSM00812. Alpha_L_fucos. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00385. ALPHA_L_FUCOSIDASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C3YWU0-1 [UniParc]FASTAAdd to Basket

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    MGLLLLLSLL SACFQPRYAP TWDSLDQRPL PSWYDEAKFG IFMHWGVFSV    50
    PSFGSEWFWW DWKGAHDQNF IKDFMKRNYP PGFRYADFAP MFTAEWYNPL 100
    QWAEVLQASG AKYVVLTSKH HEGFTNWPSK YSWNWNSVDN GPHRDLVGEL 150
    AMAIRNNSDL HFGLYYSLFE WFHPLYLKDK QNKWTTQDYT KDVGLAELYE 200
    LVNAYHPEVV WSDGDWEAPY TYWNSTNFLA WLYNDSPVKD TVVTNDRWGS 250
    GMLCHHGGYY TCSDRYNPGV LQKHKWENCM TIDKKSWGFR REATLADYLD 300
    MDDLVKILAE TVSCGGNLLM NIGPTHDGRI VPIFEERLRS MGKWLQVNGD 350
    AIYATKPWRA QNDTRESGVW YTSKNDSVYA IVLDWPNSGQ LTLGVPRSSP 400
    TTTVTMLGWA APLKWVAVSG SGITVQMPTA SSNQLPCQWA WVIRMKGVM 449
    Length:449
    Mass (Da):51,880
    Last modified:April 5, 2011 - v2
    Checksum:i932A818CAAF41315
    GO

    Sequence cautioni

    The sequence EEN55334.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG666561 Genomic DNA. Translation: EEN55334.1. Sequence problems.
    RefSeqiXP_002599322.1. XM_002599276.1.

    Genome annotation databases

    GeneIDi7207966.
    KEGGibfo:BRAFLDRAFT_56888.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG666561 Genomic DNA. Translation: EEN55334.1 . Sequence problems.
    RefSeqi XP_002599322.1. XM_002599276.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7739.JGI56888.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 7207966.
    KEGGi bfo:BRAFLDRAFT_56888.

    Phylogenomic databases

    eggNOGi COG3669.
    KOi K01206.

    Family and domain databases

    Gene3Di 2.60.40.1180. 1 hit.
    3.20.20.80. 1 hit.
    InterProi IPR016286. FUC_metazoa-typ.
    IPR013780. Glyco_hydro_13_b.
    IPR000933. Glyco_hydro_29.
    IPR018526. Glyco_hydro_29_CS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10030. PTHR10030. 1 hit.
    Pfami PF01120. Alpha_L_fucos. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001092. Alpha-L-fucosidase. 1 hit.
    PRINTSi PR00741. GLHYDRLASE29.
    SMARTi SM00812. Alpha_L_fucos. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00385. ALPHA_L_FUCOSIDASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: S238N-H82.

    Entry informationi

    Entry nameiFUCO_BRAFL
    AccessioniPrimary (citable) accession number: C3YWU0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 28 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3