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Protein

Histone deacetylase

Gene

BRAFLDRAFT_281552

Organism
Branchiostoma floridae (Florida lancelet) (Amphioxus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei95SubstrateUniRule annotation1
Active sitei137Proton acceptorUniRule annotation1
Binding sitei145Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi172Divalent metal cationUniRule annotation1
Metal bindingi174Divalent metal cationUniRule annotation1
Metal bindingi261Divalent metal cationUniRule annotation1
Binding sitei300SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
ORF Names:BRAFLDRAFT_281552Imported
OrganismiBranchiostoma floridae (Florida lancelet) (Amphioxus)Imported
Taxonomic identifieri7739 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma
Proteomesi
  • UP000001554 Componenti: Partially assembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi7739.JGI281552.

Structurei

3D structure databases

ProteinModelPortaliC3YM52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 315Hist_deacetylInterPro annotationAdd BLAST292

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1342. Eukaryota.
COG0123. LUCA.
InParanoidiC3YM52.
KOiK11404.
OMAiPRAWTHL.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

C3YM52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSTKTVAYF FDPDVGNFHY GQGHPMKPHR LALTHSLVLH YGLYKRMQVY
60 70 80 90 100
RPYRATVHDM CRFHSEDYID FLQRVTPQNV QNFTKSLQQF NVGDDCPVFP
110 120 130 140 150
GLFNFCSMYT GATLEGAVKL NNNICDIAVN WAGGLHHAKK FEASGFCYVN
160 170 180 190 200
DIVIGILELL KYHPRVLYVD IDIHHGDGVQ EAFYLTDRVM TVSFHKYGNH
210 220 230 240 250
FFPGTGDMYE VGAEGGKYYS LNVPLKDGID DHNYRQLFNP IMQQVVEFFR
260 270 280 290 300
PTCIVLQCGA DSLGCDRLGC FNLSVKGHGE CVSFMKGFNL PLLVLGGGGY
310 320 330 340 350
TVRNVARCWT HETALLLDEE VNNELPYNEY FEYFSPDFTL HPDTSTRIEN
360 370 380 390 400
CNTKGYLEQI RQTINDNLKS LSHAPSVQMH DIPPDLFSLE VVEEPDPDIR
410 420 430
ESVQDQDNRI EPANEYYDGD KDQDRDNDLD V
Length:431
Mass (Da):49,185
Last modified:July 28, 2009 - v1
Checksum:i9B647A80C9E8953C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG666529 Genomic DNA. Translation: EEN58646.1.
RefSeqiXP_002602634.1. XM_002602588.1.
UniGeneiBfl.13769.

Genome annotation databases

GeneIDi7235651.
KEGGibfo:BRAFLDRAFT_281552.

Similar proteinsi

Entry informationi

Entry nameiC3YM52_BRAFL
AccessioniPrimary (citable) accession number: C3YM52
Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: August 30, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported