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C3Y4N1

- C3Y4N1_BRAFL

UniProt

C3Y4N1 - C3Y4N1_BRAFL

Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

BRAFLDRAFT_58105

Organism
Branchiostoma floridae (Florida lancelet) (Amphioxus)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (28 Jul 2009)
      Previous versions | rss
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    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

    Catalytic activityi

    Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.

    Cofactori

    Binds 1 lipoyl cofactor covalently.UniRule annotation
    Binds 2 lipoyl cofactors covalently.UniRule annotation
    Binds 3 lipoyl cofactors covalently.UniRule annotation

    GO - Molecular functioni

    1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pyruvate metabolic process Source: InterPro

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotation, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
    Gene namesi
    ORF Names:BRAFLDRAFT_58105Imported
    OrganismiBranchiostoma floridae (Florida lancelet) (Amphioxus)Imported
    Taxonomic identifieri7739 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma
    ProteomesiUP000001554: Partially assembled WGS sequence

    Subcellular locationi

    Mitochondrion matrix UniRule annotation

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell
    2. pyruvate dehydrogenase complex Source: InterPro

    Interactioni

    Protein-protein interaction databases

    STRINGi7739.JGI58105.

    Structurei

    3D structure databases

    ProteinModelPortaliC3Y4N1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 lipoyl-binding domain.UniRule annotation

    Keywords - Domaini

    LipoylUniRule annotation

    Phylogenomic databases

    eggNOGiCOG0508.
    KOiK00627.
    OMAiPISNIRK.

    Family and domain databases

    Gene3Di3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR006257. LAT1.
    IPR011053. Single_hybrid_motif.
    [Graphical view]
    PfamiPF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF02817. E3_binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 1 hit.
    TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
    PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
    PS00189. LIPOYL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C3Y4N1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEMGTIVSWE KQVGDQLNEG DLLAEIETDK ATMGFETPEE GYLARIFIEA    50
    GEKDIPIGKL LCIIVENEDD IAKFKDWIPP ADAESAEKPL PKPVSESPST 100
    PPPAAAAPPP PPPPPMAAMP PPPTPAAPPP TPGARVFASP LAKKLAADKG 150
    IDLSLVSGTG PGGRIRSQDI EAFTPAAAPA PAVAPAAPAA APVGTFVDIP 200
    LTNVRKVIAS RLLQSKTTIP HYYLSVDINM DNVIALRKEL NAIVEKEDVK 250
    LSVNDFIIKA AALSCLKVPE CNSSWMDSVI RQYNKVDVNV AVSTDSGLIT 300
    PIVFNAHTKG LAAINSDVIS LAARAREGKL QLQEFQGGTF TVSNLGMFGI 350
    KNFSAVINPP QACILAVGGA VKTVVPDADA ENGLSVATMM SVTLSCDHRV 400
    VDGAVGAQWL QEFKLYLEKP ETMLL 425
    Length:425
    Mass (Da):44,892
    Last modified:July 28, 2009 - v1
    Checksum:i48A944BD3A8053D5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG666486 Genomic DNA. Translation: EEN64688.1.
    RefSeqiXP_002608678.1. XM_002608632.1.
    UniGeneiBfl.8179.

    Genome annotation databases

    GeneIDi7238166.
    KEGGibfo:BRAFLDRAFT_58105.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GG666486 Genomic DNA. Translation: EEN64688.1 .
    RefSeqi XP_002608678.1. XM_002608632.1.
    UniGenei Bfl.8179.

    3D structure databases

    ProteinModelPortali C3Y4N1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7739.JGI58105.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 7238166.
    KEGGi bfo:BRAFLDRAFT_58105.

    Phylogenomic databases

    eggNOGi COG0508.
    KOi K00627.
    OMAi PISNIRK.

    Family and domain databases

    Gene3Di 3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR006257. LAT1.
    IPR011053. Single_hybrid_motif.
    [Graphical view ]
    Pfami PF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF02817. E3_binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 1 hit.
    TIGRFAMsi TIGR01349. PDHac_trf_mito. 1 hit.
    PROSITEi PS50968. BIOTINYL_LIPOYL. 1 hit.
    PS00189. LIPOYL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: S238N-H82Imported.
      Tissue: TestesImported.

    Entry informationi

    Entry nameiC3Y4N1_BRAFL
    AccessioniPrimary (citable) accession number: C3Y4N1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 28, 2009
    Last sequence update: July 28, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3