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C3Y4N1

- C3Y4N1_BRAFL

UniProt

C3Y4N1 - C3Y4N1_BRAFL

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Protein
Acetyltransferase component of pyruvate dehydrogenase complex
Gene
BRAFLDRAFT_58105
Organism
Branchiostoma floridae (Florida lancelet) (Amphioxus)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2 By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

Binds 1 lipoyl cofactor covalently By similarity.UniRule annotation
Binds 2 lipoyl cofactors covalently By similarity.UniRule annotation
Binds 3 lipoyl cofactors covalently By similarity.UniRule annotation

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: InterPro

GO - Biological processi

  1. pyruvate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
ORF Names:BRAFLDRAFT_58105Imported
OrganismiBranchiostoma floridae (Florida lancelet) (Amphioxus)
Taxonomic identifieri7739 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma
ProteomesiUP000001554: Partially assembled WGS sequence

Subcellular locationi

Mitochondrion matrix By similarity UniRule annotation

GO - Cellular componenti

  1. pyruvate dehydrogenase complex Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi7739.JGI58105.

Structurei

3D structure databases

ProteinModelPortaliC3Y4N1.

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 1 lipoyl-binding domain.UniRule annotation

Keywords - Domaini

LipoylUniRule annotation

Phylogenomic databases

eggNOGiCOG0508.
KOiK00627.
OMAiPISNIRK.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3Y4N1-1 [UniParc]FASTAAdd to Basket

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MEMGTIVSWE KQVGDQLNEG DLLAEIETDK ATMGFETPEE GYLARIFIEA    50
GEKDIPIGKL LCIIVENEDD IAKFKDWIPP ADAESAEKPL PKPVSESPST 100
PPPAAAAPPP PPPPPMAAMP PPPTPAAPPP TPGARVFASP LAKKLAADKG 150
IDLSLVSGTG PGGRIRSQDI EAFTPAAAPA PAVAPAAPAA APVGTFVDIP 200
LTNVRKVIAS RLLQSKTTIP HYYLSVDINM DNVIALRKEL NAIVEKEDVK 250
LSVNDFIIKA AALSCLKVPE CNSSWMDSVI RQYNKVDVNV AVSTDSGLIT 300
PIVFNAHTKG LAAINSDVIS LAARAREGKL QLQEFQGGTF TVSNLGMFGI 350
KNFSAVINPP QACILAVGGA VKTVVPDADA ENGLSVATMM SVTLSCDHRV 400
VDGAVGAQWL QEFKLYLEKP ETMLL 425
Length:425
Mass (Da):44,892
Last modified:July 28, 2009 - v1
Checksum:i48A944BD3A8053D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG666486 Genomic DNA. Translation: EEN64688.1.
RefSeqiXP_002608678.1. XM_002608632.1.
UniGeneiBfl.8179.

Genome annotation databases

GeneIDi7238166.
KEGGibfo:BRAFLDRAFT_58105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG666486 Genomic DNA. Translation: EEN64688.1 .
RefSeqi XP_002608678.1. XM_002608632.1.
UniGenei Bfl.8179.

3D structure databases

ProteinModelPortali C3Y4N1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7739.JGI58105.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 7238166.
KEGGi bfo:BRAFLDRAFT_58105.

Phylogenomic databases

eggNOGi COG0508.
KOi K00627.
OMAi PISNIRK.

Family and domain databases

Gene3Di 3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view ]
Pfami PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view ]
SUPFAMi SSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsi TIGR01349. PDHac_trf_mito. 1 hit.
PROSITEi PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S238N-H82Imported.
    Tissue: TestesImported.

Entry informationi

Entry nameiC3Y4N1_BRAFL
AccessioniPrimary (citable) accession number: C3Y4N1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: July 9, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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