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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

BRAFLDRAFT_58105

Organism
Branchiostoma floridae (Florida lancelet) (Amphioxus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • (R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation
  • (R)-lipoateUniRule annotationNote: Binds 2 lipoyl cofactors covalently.UniRule annotation
  • (R)-lipoateUniRule annotationNote: Binds 3 lipoyl cofactors covalently.UniRule annotation

GO - Molecular functioni

  1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyruvate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
ORF Names:BRAFLDRAFT_58105Imported
OrganismiBranchiostoma floridae (Florida lancelet) (Amphioxus)Imported
Taxonomic identifieri7739 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma
ProteomesiUP000001554 Componenti: Partially assembled WGS sequence

Subcellular locationi

Mitochondrion matrix UniRule annotation

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
  2. pyruvate dehydrogenase complex Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi7739.JGI58105.

Family & Domainsi

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation
Contains 1 lipoyl-binding domain.UniRule annotation

Keywords - Domaini

LipoylUniRule annotation

Phylogenomic databases

eggNOGiCOG0508.
InParanoidiC3Y4N1.
KOiK00627.
OMAiATMEFES.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3Y4N1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMGTIVSWE KQVGDQLNEG DLLAEIETDK ATMGFETPEE GYLARIFIEA
60 70 80 90 100
GEKDIPIGKL LCIIVENEDD IAKFKDWIPP ADAESAEKPL PKPVSESPST
110 120 130 140 150
PPPAAAAPPP PPPPPMAAMP PPPTPAAPPP TPGARVFASP LAKKLAADKG
160 170 180 190 200
IDLSLVSGTG PGGRIRSQDI EAFTPAAAPA PAVAPAAPAA APVGTFVDIP
210 220 230 240 250
LTNVRKVIAS RLLQSKTTIP HYYLSVDINM DNVIALRKEL NAIVEKEDVK
260 270 280 290 300
LSVNDFIIKA AALSCLKVPE CNSSWMDSVI RQYNKVDVNV AVSTDSGLIT
310 320 330 340 350
PIVFNAHTKG LAAINSDVIS LAARAREGKL QLQEFQGGTF TVSNLGMFGI
360 370 380 390 400
KNFSAVINPP QACILAVGGA VKTVVPDADA ENGLSVATMM SVTLSCDHRV
410 420
VDGAVGAQWL QEFKLYLEKP ETMLL
Length:425
Mass (Da):44,892
Last modified:July 28, 2009 - v1
Checksum:i48A944BD3A8053D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG666486 Genomic DNA. Translation: EEN64688.1.
RefSeqiXP_002608678.1. XM_002608632.1.
UniGeneiBfl.8179.

Genome annotation databases

GeneIDi7238166.
KEGGibfo:BRAFLDRAFT_58105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG666486 Genomic DNA. Translation: EEN64688.1.
RefSeqiXP_002608678.1. XM_002608632.1.
UniGeneiBfl.8179.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7739.JGI58105.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi7238166.
KEGGibfo:BRAFLDRAFT_58105.

Phylogenomic databases

eggNOGiCOG0508.
InParanoidiC3Y4N1.
KOiK00627.
OMAiATMEFES.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S238N-H82Imported.
    Tissue: TestesImported.

Entry informationi

Entry nameiC3Y4N1_BRAFL
AccessioniPrimary (citable) accession number: C3Y4N1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: April 1, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.