ID   C3Y276_BRAFL            Unreviewed;       902 AA.
AC   C3Y276;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   24-JAN-2024, entry version 93.
DE   RecName: Full=Histone-lysine N-methyltransferase ASH1L {ECO:0008006|Google:ProtNLM};
GN   ORFNames=BRAFLDRAFT_124382 {ECO:0000313|EMBL:EEN65966.1};
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomatidae; Branchiostoma.
OX   NCBI_TaxID=7739;
RN   [1] {ECO:0000313|EMBL:EEN65966.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN65966.1};
RC   TISSUE=Testes {ECO:0000313|EMBL:EEN65966.1};
RX   PubMed=18563158; DOI=10.1038/nature06967;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA   Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA   Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA   Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA   Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA   Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA   Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA   Satoh N., Rokhsar D.S.;
RT   "The amphioxus genome and the evolution of the chordate karyotype.";
RL   Nature 453:1064-1071(2008).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; GG666480; EEN65966.1; -; Genomic_DNA.
DR   RefSeq; XP_002609956.1; XM_002609910.1.
DR   AlphaFoldDB; C3Y276; -.
DR   STRING; 7739.C3Y276; -.
DR   eggNOG; KOG1083; Eukaryota.
DR   InParanoid; C3Y276; -.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR   GO; GO:0042800; F:histone H3K4 methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR   CDD; cd05525; Bromo_ASH1; 1.
DR   CDD; cd15548; PHD_ASH1L; 1.
DR   CDD; cd19174; SET_ASH1L; 1.
DR   Gene3D; 2.30.30.490; -; 1.
DR   Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR001025; BAH_dom.
DR   InterPro; IPR043151; BAH_sf.
DR   InterPro; IPR043320; Bromo_ASH1L.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR043319; PHD_ASH1L.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR46147; HISTONE-LYSINE N-METHYLTRANSFERASE ASH1; 1.
DR   PANTHER; PTHR46147:SF3; HISTONE-LYSINE N-METHYLTRANSFERASE ASH1; 1.
DR   Pfam; PF17907; AWS; 1.
DR   Pfam; PF01426; BAH; 1.
DR   Pfam; PF00439; Bromodomain; 1.
DR   Pfam; PF20826; PHD_5; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00570; AWS; 1.
DR   SMART; SM00439; BAH; 1.
DR   SMART; SM00297; BROMO; 1.
DR   SMART; SM00249; PHD; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF47370; Bromodomain; 1.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS51038; BAH; 1.
DR   PROSITE; PS50014; BROMODOMAIN_2; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
PE   4: Predicted;
KW   Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW   Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          60..110
FT                   /note="AWS"
FT                   /evidence="ECO:0000259|PROSITE:PS51215"
FT   DOMAIN          113..229
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   DOMAIN          237..253
FT                   /note="Post-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50868"
FT   DOMAIN          435..505
FT                   /note="Bromo"
FT                   /evidence="ECO:0000259|PROSITE:PS50014"
FT   DOMAIN          635..752
FT                   /note="BAH"
FT                   /evidence="ECO:0000259|PROSITE:PS51038"
FT   REGION          262..319
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          779..860
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        290..305
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        797..843
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        844..860
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   902 AA;  104186 MW;  17AA275544E8B6A0 CRC64;
     MYSTFAAGKY LRQKRIDFQM PYDIWWQYKH NKLIPKIDER TKYKKIRSNI FVDVKPLSGC
     EPVVCTCVRP AQADKACQED CLNRMSFMEC SPNTCPYADQ CANQRIQRHE WDPGLERIVT
     KDRGYGVRSK TPIPQGNFIL EYVGEVVSEQ EFRRRTVEIY HDHNHHYCLN LHSGAVIDGY
     KYGCEGRFVN HSCEPNCEMQ KWSVNGVYRI GLFALRDIPA GEELTYDYNF HAFNMEKQQI
     CKCGSAKCRG FIGGKNQRFN GALNNKPVAK NSGAKTRKSK TRLKKREQHS QQQSQGAQQQ
     HPTPQHHLPR FGEPPQVIYK SCPHTIKPLS ARERNLVQKH KMFLLRNWER VRNTNEAMKK
     KSSQETKSAS TAVGGAYIPK TDVFMTQFTA LKTSRSVRTR RLAAAEENSE VTRTARLAQV
     LKDIYNTVVN HKDTKGQALA APLMILPNRK RNSEYYSMIP DPLDLTTIEN KIMTGKYKTM
     DDFEANMQQV FRNAEKFHGK KSPIGKDVCR LRKVYTTARS DASRQLEEIL GEVSGEPDTT
     EMVEETVRDP EKDESDDDII RCICGIFKDE GLMIQCEKCM VWQHCDCMRT TDDVEHYLCE
     ECDPRQVDRE VPMVPQPPYA NRGCTYYLTL LRDDLLVRQG DCVYLMRDQS QRRSVDGKSV
     RTSYRLLSNI SPDKLDVFRV EKLWKNEKKF FPNELFRVPL YEIIPLEAVV GLCCVMDLKT
     FCKGRPKTVK EQDVYVCDYR LDRTAHLFYK TTKTKYPICT KPYAFDHFEK RLVPKRTYTP
     HHVPEHYKKT GGRPYWKSNR QDGSSETSST MGDSIDQAST SGLEEPVISD NISPSSSAEE
     APISSEPHKT KQRPKQKERL NNVLLKLLAK LPGKHKPVDV SYLLEEGAGK RQRKKTTLVD
     CW
//