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C3XPZ3 (C3XPZ3_BRAFL) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
ORF Names:BRAFLDRAFT_118445 EMBL EEN70014.1
OrganismBranchiostoma floridae (Florida lancelet) (Amphioxus)
Taxonomic identifier7739 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Cephalochordata › Branchiostomidae › Branchiostoma

Protein attributes

Sequence length485 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109 RuleBase RU004281

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding13 – 186NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding36 – 383NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding78 – 803NADP By similarity PIRSR PIRSR000109-3
Region132 – 1343Substrate binding By similarity PIRSR PIRSR000109-2
Region189 – 1902Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1861Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1931Proton donor By similarity PIRSR PIRSR000109-1
Binding site1061NADP By similarity PIRSR PIRSR000109-3
Binding site1061Substrate By similarity PIRSR PIRSR000109-2
Binding site1941Substrate By similarity PIRSR PIRSR000109-2
Binding site2631Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2901Substrate By similarity PIRSR PIRSR000109-2
Binding site4491Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4551Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
C3XPZ3 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: BBB3A703C3654FA3

FASTA48553,144
        10         20         30         40         50         60 
MAPEPQADIA LIGLAVMGQN LILNMNDHGF VVCAFNRTVS KVDDFLAKEA KGTKVVGARS 

        70         80         90        100        110        120 
MEEMVGMLKK PRRVMMLVKA GSAVDAFIDK LVPLLEKGDI IIDGGNSEYT DSRRRCAALK 

       130        140        150        160        170        180 
EKGLHFVGSG VSGGEEGARQ GPSLVPGGSP EAWPHIKPIF QSVAAKVGDE PCCDWVGEDG 

       190        200        210        220        230        240 
AGHFVKMVHN GIEYGDMQLI CEAYHLMKDV LKMDNDEMSA VFTEWNKSEL DSFLIEISAN 

       250        260        270        280        290        300 
ILKFRDDDGK HLLDKIRDAA GQKGTGKWTA ISALDYGMPV TLIGEAVFAR CLSSLQQERV 

       310        320        330        340        350        360 
DASKQLPAPE GPKFKIDKPA FVEQIRKALY ASKIVSYAQG FMLLREAARQ FNWNLNYGGI 

       370        380        390        400        410        420 
ALMWRGGCII RSRFLGNIKE AFVKNPNLNN LLLDDFFKAE IAKCQESWRQ VVSMAVTAGV 

       430        440        450        460        470        480 
PVPAFSTALA FYDGYRAARL PANLIQAQRD YFGAHTYELL DSPGKFQHTN WTGTGGDVSA 


GTYNA

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		GG666451 Genomic DNA. Translation: EEN70014.1.
RefSeqXP_002614005.1. XM_002613959.1.
UniGeneBfl.3588.

3D structure databases

ProteinModelPortalC3XPZ3.
ModBaseSearch...

Protein-protein interaction databases

STRINGC3XPZ3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7217153.
KEGGbfo:BRAFLDRAFT_118445.

Phylogenomic databases

OMASNYPDTN.
PhylomeDBC3XPZ3.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC3XPZ3_BRAFL
AccessionPrimary (citable) accession number: C3XPZ3
Entry history
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: December 14, 2011
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info