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Protein

DNA ligase

Gene

BRAFLDRAFT_119901

Organism
Branchiostoma floridae (Florida lancelet) (Amphioxus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotation
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:BRAFLDRAFT_119901Imported
OrganismiBranchiostoma floridae (Florida lancelet) (Amphioxus)Imported
Taxonomic identifieri7739 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCephalochordataBranchiostomidaeBranchiostoma
Proteomesi
  • UP000001554 Componenti: Partially assembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

Protein-protein interaction databases

STRINGi7739.JGI119901

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 105PARP-typeInterPro annotationAdd BLAST93
Domaini492 – 626DNA_LIGASE_A3InterPro annotationAdd BLAST135
Domaini848 – 928BRCTInterPro annotationAdd BLAST81

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG4437 Eukaryota
COG1793 LUCA
InParanoidiC3XPG8
KOiK10776
OMAiDCIYFND

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
3.30.1740.10, 1 hit
3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR031916 LIG3_BRCT
IPR012340 NA-bd_OB-fold
IPR019406 Znf_C2H2_APLF-like
IPR001510 Znf_PARP
IPR036957 Znf_PARP_sf
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
PF16759 LIG3_BRCT, 1 hit
PF10283 zf-CCHH, 1 hit
PF00645 zf-PARP, 1 hit
SMARTiView protein in SMART
SM01336 zf-PARP, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
SSF52113 SSF52113, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit
PS00347 PARP_ZN_FINGER_1, 1 hit
PS50064 PARP_ZN_FINGER_2, 1 hit

Sequencei

Sequence statusi: Complete.

C3XPG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHRENKGLRT SRFCVEYAKQ GRAGCKKCKQ KIEKGLPRIG KIVPNFFHEG
60 70 80 90 100
DGEMKQWYHV ACIFETFQRA RATTKKIEDA SDLEGWEDME DEEKQTILKL
110 120 130 140 150
IKELESKAKS PKKKVVQATL STKGKIQSPT KKAASSATVS DDSPAAGPSS
160 170 180 190 200
SSSASTSVSM TSPTPTPDID HKDNAFREFR RLCALIAEEP GYNAKTKLVS
210 220 230 240 250
DFLKKGSNGD GFKGDTFLVV KLLLPGVVKR VYNLNNKQLL KHFANIFGVN
260 270 280 290 300
LADMLTDLEL GDVSETVRKF FEESERCLPA KKSKLTIQEV DESLEILAQM
310 320 330 340 350
TKEDDQMREL NKIAKKCTAN DLKVVVRLIK HDLRINAGAK HILEGLDPNA
360 370 380 390 400
YPAFQASRNL ADVVERVVAN GCAPGMKKSL SIKANLMTPV LPMLAEACKS
410 420 430 440 450
VEMAMRKCPN GMYAEIKYDG ERVQVHKQGN KFEYFSRSLK PVLPHKVAHF
460 470 480 490 500
KDYIPKAFPH GSNMILDSEV LLVDTNTGNP LPFGTLGIHK KQQFSDAQVA
510 520 530 540 550
LFVFDCIYFN GETLMDRPIS ERRKFLEDNM TVIPNRVVLS EYRYITEPGD
560 570 580 590 600
LSDMIGRVIR DGLEGLVLKD TKSIYEPGKR HWLKVKKDYL EQGAMADTAD
610 620 630 640 650
LVVLGAFYGT GNKGGLKSVF LMGVYDPDSD KWCTVTKCGN GHDDNTIAKL
660 670 680 690 700
NKELAMVKIS KDMSKVPKWL KITKNLVPDF VCADPKKAPV WEITGAEFSK
710 720 730 740 750
SEAHTADGIS IRFPRVTKIR DDKDWKSATN LKQLKHLFKT SKETSDIPDL
760 770 780 790 800
LKGKGKSPRK PVKVKVEEED DDDDDDDDSN GGASSNGVTP IKGMKRKAEE
810 820 830 840 850
DSPRTPKKSK PTCRYGATCY QTGKEHLDKF DHPTRKSPKK SNSAAKSVLP
860 870 880 890 900
DVFCGIKLFL PDTVENYALL RRYFVAYDGD IVQDYAMSQA THVVEDPEQK
910 920
NMNGKTDAQL VTVDWLWQCI KRKQLVPV
Length:928
Mass (Da):103,861
Last modified:July 28, 2009 - v1
Checksum:i3CD9F7EE4715580B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG666451 Genomic DNA Translation: EEN69839.1
RefSeqiXP_002613830.1, XM_002613784.1
UniGeneiBfl.20221

Genome annotation databases

GeneIDi7222688
KEGGibfo:BRAFLDRAFT_119901

Similar proteinsi

Entry informationi

Entry nameiC3XPG8_BRAFL
AccessioniPrimary (citable) accession number: C3XPG8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: March 28, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health