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Protein

Protein NLRC5

Gene

Nlrc5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi229 – 236ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity, Innate immunity

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NLRC5
Gene namesi
Name:Nlrc5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:3612191. Nlrc5.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: BHF-UCL
  • nucleus Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003978671 – 1915Protein NLRC5Add BLAST1915

Proteomic databases

EPDiC3VPR6.
PeptideAtlasiC3VPR6.
PRIDEiC3VPR6.

PTM databases

iPTMnetiC3VPR6.
PhosphoSitePlusiC3VPR6.

Expressioni

Tissue specificityi

Expressed in spleen, thymus and lung.1 Publication

Inductioni

By interferon gamma. By LPS and viruses (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000074151.
ExpressionAtlasiC3VPR6. baseline and differential.
GenevisibleiC3VPR6. MM.

Interactioni

Subunit structurei

Interacts with CHUK and IKBKB; prevents CHUK and IKBKB phosphorylation and inhibits their kinase activity. Interacts with DDX58 and IFIH1; blocks the interaction of MAVS to DDX58.By similarity

Protein-protein interaction databases

IntActiC3VPR6. 2 interactors.

Structurei

Secondary structure

11915
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 4Combined sources3
Helixi11 – 22Combined sources12
Helixi25 – 35Combined sources11
Beta strandi45 – 48Combined sources4
Helixi50 – 63Combined sources14
Helixi65 – 78Combined sources14
Helixi86 – 90Combined sources5
Helixi91 – 93Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MJMNMR-A1-96[»]
ProteinModelPortaliC3VPR6.
SMRiC3VPR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini223 – 542NACHTPROSITE-ProRule annotationAdd BLAST320
Repeati622 – 646LRR 1Add BLAST25
Repeati716 – 740LRR 2Add BLAST25
Repeati744 – 771LRR 3Add BLAST28
Repeati772 – 796LRR 4Add BLAST25
Repeati871 – 898LRR 5Add BLAST28
Repeati900 – 923LRR 6Add BLAST24
Repeati930 – 953LRR 7Add BLAST24
Repeati1006 – 1033LRR 8Add BLAST28
Repeati1034 – 1055LRR 9Add BLAST22
Repeati1138 – 1161LRR 10Add BLAST24
Repeati1162 – 1184LRR 11Add BLAST23
Repeati1240 – 1263LRR 12Add BLAST24
Repeati1265 – 1292LRR 13Add BLAST28
Repeati1348 – 1371LRR 14Add BLAST24
Repeati1481 – 1504LRR 15Add BLAST24
Repeati1519 – 1542LRR 16Add BLAST24
Repeati1552 – 1575LRR 17Add BLAST24
Repeati1576 – 1598LRR 18Add BLAST23
Repeati1603 – 1626LRR 19Add BLAST24
Repeati1631 – 1654LRR 20Add BLAST24
Repeati1659 – 1682LRR 21Add BLAST24
Repeati1687 – 1711LRR 22Add BLAST25
Repeati1715 – 1738LRR 23Add BLAST24
Repeati1741 – 1768LRR 24Add BLAST28
Repeati1769 – 1795LRR 25Add BLAST27
Repeati1821 – 1845LRR 26Add BLAST25
Repeati1849 – 1872LRR 27Add BLAST24

Sequence similaritiesi

Belongs to the NLRP family.Curated
Contains 27 LRR (leucine-rich) repeats.Curated
Contains 1 NACHT domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

GeneTreeiENSGT00860000133673.
HOGENOMiHOG000168392.
HOVERGENiHBG108194.
InParanoidiC3VPR6.
OMAiIRLWNNP.
OrthoDBiEOG091G01CG.
PhylomeDBiC3VPR6.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.80.10.10. 6 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 7 hits.
[Graphical view]
SMARTiSM00367. LRR_CC. 13 hits.
SM00369. LRR_TYP. 9 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50837. NACHT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: C3VPR6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDAESIRLNN ENLWAWLVRL LSKNPEWLSA KLRSFLPTMD LDCSYEPSNP
60 70 80 90 100
EVIHRQLNRL FAQGMATWKS FINDLCFELD VPLDMEIPLV SIWGPRDEFS
110 120 130 140 150
KQLGAGEESC PGPQLYHGAK RPFQSYGSSP RRKNSKKQQL ELAKKYLKLL
160 170 180 190 200
KTSAQQWHGG VCPGAWLTPH SPQTYIPPVL QWSRATAPLD AQEGATLGDP
210 220 230 240 250
EAADNIDVSI QDLFSFKAHK GPRVTVLLGK AGMGKTTLAY RLRWRWAQGQ
260 270 280 290 300
LDRFQALFLF EFRQLNMITQ LPTLPQLLFD LYLMPESEPD AVFQYLKENA
310 320 330 340 350
QEVLLIFDGL DEALHADSVG TDNAGSALTL FSELCHGNLL PGCWVMTTSR
360 370 380 390 400
PGKLPSCVPT EAATVHMWGF DGLRVEKYVT CFFSDLLSQE LALKEMRTNA
410 420 430 440 450
RLRGMCAIPA LCTVTCFCLR RLLPGSSPGQ SAALLPTITQ LYLQMVETFS
460 470 480 490 500
PSETLLDTSI LGFGKVALRG LDTGKVVFSV EDISPQLMSF GAVHSLLTSF
510 520 530 540 550
CIHTRPGHEE IGYAFVHLSL QEFFAALYLM ASHTVDKDTL VEYVTLNSHW
560 570 580 590 600
VLRTKGRLGL SDHLPAFLAG LASHTCHMFL CQLAQQDRAW VGSRQAAVIQ
610 620 630 640 650
VLRKLASRKL TGPKMIELYH CVAETQDLEL ARFTAQSLPS RLSFHNFPLT
660 670 680 690 700
HADLAALANI LEHRDDPIHL DFDGCPLEPH CPEALVGCGQ VENLSFKSRK
710 720 730 740 750
CGDAFAEALC RSLPTMGSLK TLGLTGSRIT AQGISHLIQT LPLCSQLEEV
760 770 780 790 800
SLHDNQLKDP EVLSLVELLP SLPKLQKLDL SRNSFSRSIL LSLVKVAITC
810 820 830 840 850
PTVRKLQVRE LDLIFYLSPV TETATQQSGA SDVQGKDSLK EGQSRSLQLR
860 870 880 890 900
LQKCQLRIRD AEALVELFQK SPQLEEVNLS GNHLEDDGCR LVAEAASQLH
910 920 930 940 950
IAQKLDLSDN GLSQTGVTYV LKAMSTCGTL EDLHISLLNN TVVLTFAQEP
960 970 980 990 1000
REQEGSCKGR APLISFVSPV TSELSQRSRR IRLTHCGFLA KHTETLCEAL
1010 1020 1030 1040 1050
RASCQTHNLD HLDLSDNSLG GKGVILLTEL LPGLGPLKSL NLSRNGLSMD
1060 1070 1080 1090 1100
AVFSLVQCLS SLQWVFHLDV SLESDCIFLR GAGTSRDALE PKFQTGVQVL
1110 1120 1130 1140 1150
ELSQRYTSRS FCLQECQLEP TSLTFLCATL EKSPGPLEVQ LSCKSLSDDS
1160 1170 1180 1190 1200
LKILLQCLPQ LPQLSLLQLR HTVLSSRSPF LLADIFNLCP RVRKVTLRSL
1210 1220 1230 1240 1250
CHAVLHFDSN EEQEGVCCGF PGCSLSQEHM ETLCCALSKC NALSQLDLTD
1260 1270 1280 1290 1300
NLLGDIGLRC LLECLPQLPI SGWLDLSHNN ISQEGILYLL ETLPSYPNIQ
1310 1320 1330 1340 1350
EVSVSLSSEQ IFRMCFSKKE GAGTSLRLCE CSFSPEQVSK LASSLSQAQQ
1360 1370 1380 1390 1400
LTELWLTKCH LDLPQLTMLL NLVNRPTGLL GLRLEEPWVD SVSLPALMEV
1410 1420 1430 1440 1450
CAQASGCLTE LSISEIQRKL WLQLEFPHQE GNSDSMALRL AHCDLETEHS
1460 1470 1480 1490 1500
HLMIQLVETY ARLQQLSLSQ VSFNDNDGTS SKLLQNILLS SCELKSFRLT
1510 1520 1530 1540 1550
FSQVSTKSLT HLAFGLGHCH HLEELDFSNN SLREEDTELL MGALQGTCRL
1560 1570 1580 1590 1600
KKLHLSFLPL GASSLALLIQ GLSRMTLLQD LCLSHNQIGD VGTQCLAAIL
1610 1620 1630 1640 1650
PKLPELRKFD LSHNQIGDVG TQCLAAILPK LPELRKFNLS HNQIGHVGTQ
1660 1670 1680 1690 1700
CLAAILPKLP ELRKFDLSRN QIGDVGTQCL AAILPKLPEL RKFDLSGNRI
1710 1720 1730 1740 1750
GPAGGVQLVK SLTHFEHLEE IKLGNNALGE PTALELAQRL PPQLRVLCLP
1760 1770 1780 1790 1800
SSHLGPEGAL GLAQALEQCP HIEEVSLAEN NLAGGVPRFS KRLPLLRQID
1810 1820 1830 1840 1850
LEFCKIEDQA ARHLAANLTL FPALEKLLLS GNLLGDEVAA ELAQVLPQMG
1860 1870 1880 1890 1900
QLKKVNLEWN RITARGAQLL AQGLVQGSCV PVIRLWNNPI LNDVAQSLQS
1910
QEPRLDFSIT DQQTL
Length:1,915
Mass (Da):211,710
Last modified:October 5, 2010 - v2
Checksum:i731919C80F353C1F
GO
Isoform 2 (identifier: C3VPR6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1384-1392: LEEPWVDSV → YLPALGRRV
     1393-1915: Missing.

Note: Due to intron retention. No experimental confirmation available.
Show »
Length:1,392
Mass (Da):154,279
Checksum:i9C778B0056FD1050
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti489 – 490SF → AS in BAD90135 (PubMed:12465718).Curated2
Sequence conflicti578M → T in BAD90135 (PubMed:12465718).Curated1
Sequence conflicti641R → C in BAD90135 (PubMed:12465718).Curated1
Sequence conflicti646N → K in BAD90135 (PubMed:12465718).Curated1
Sequence conflicti833V → I in BAD90135 (PubMed:12465718).Curated1
Sequence conflicti881G → R in ACP40992 (PubMed:20434986).Curated1
Sequence conflicti896A → T in BAD90135 (PubMed:12465718).Curated1
Sequence conflicti939N → S in BAD90135 (PubMed:12465718).Curated1
Sequence conflicti1105R → Q in BAD90135 (PubMed:12465718).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0397021384 – 1392LEEPWVDSV → YLPALGRRV in isoform 2. 1 Publication9
Alternative sequenceiVSP_0397031393 – 1915Missing in isoform 2. 1 PublicationAdd BLAST523

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ889356 mRNA. Translation: ACP40992.1.
AK220210 mRNA. Translation: BAD90135.1.
CCDSiCCDS59741.1. [C3VPR6-1]
RefSeqiNP_001028379.2. NM_001033207.3. [C3VPR6-1]
XP_006531225.1. XM_006531162.2. [C3VPR6-1]
XP_006531226.1. XM_006531163.2. [C3VPR6-1]
XP_011246730.1. XM_011248428.1. [C3VPR6-1]
UniGeneiMm.334720.

Genome annotation databases

EnsembliENSMUST00000053085; ENSMUSP00000138322; ENSMUSG00000074151. [C3VPR6-1]
ENSMUST00000211816; ENSMUSP00000148677; ENSMUSG00000074151. [C3VPR6-1]
GeneIDi434341.
KEGGimmu:434341.
UCSCiuc009mwj.2. mouse. [C3VPR6-2]
uc012gio.1. mouse. [C3VPR6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ889356 mRNA. Translation: ACP40992.1.
AK220210 mRNA. Translation: BAD90135.1.
CCDSiCCDS59741.1. [C3VPR6-1]
RefSeqiNP_001028379.2. NM_001033207.3. [C3VPR6-1]
XP_006531225.1. XM_006531162.2. [C3VPR6-1]
XP_006531226.1. XM_006531163.2. [C3VPR6-1]
XP_011246730.1. XM_011248428.1. [C3VPR6-1]
UniGeneiMm.334720.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MJMNMR-A1-96[»]
ProteinModelPortaliC3VPR6.
SMRiC3VPR6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiC3VPR6. 2 interactors.

PTM databases

iPTMnetiC3VPR6.
PhosphoSitePlusiC3VPR6.

Proteomic databases

EPDiC3VPR6.
PeptideAtlasiC3VPR6.
PRIDEiC3VPR6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053085; ENSMUSP00000138322; ENSMUSG00000074151. [C3VPR6-1]
ENSMUST00000211816; ENSMUSP00000148677; ENSMUSG00000074151. [C3VPR6-1]
GeneIDi434341.
KEGGimmu:434341.
UCSCiuc009mwj.2. mouse. [C3VPR6-2]
uc012gio.1. mouse. [C3VPR6-1]

Organism-specific databases

CTDi84166.
MGIiMGI:3612191. Nlrc5.

Phylogenomic databases

GeneTreeiENSGT00860000133673.
HOGENOMiHOG000168392.
HOVERGENiHBG108194.
InParanoidiC3VPR6.
OMAiIRLWNNP.
OrthoDBiEOG091G01CG.
PhylomeDBiC3VPR6.

Miscellaneous databases

PROiC3VPR6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074151.
ExpressionAtlasiC3VPR6. baseline and differential.
GenevisibleiC3VPR6. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.80.10.10. 6 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR006553. Leu-rich_rpt_Cys-con_subtyp.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF13516. LRR_6. 7 hits.
[Graphical view]
SMARTiSM00367. LRR_CC. 13 hits.
SM00369. LRR_TYP. 9 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50837. NACHT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNLRC5_MOUSE
AccessioniPrimary (citable) accession number: C3VPR6
Secondary accession number(s): Q571H9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: October 5, 2010
Last modified: November 30, 2016
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Supposed to contain a CARD domain at the N-terminus. However, this domain is not detected by Pfam, PROSITE or SMART. Has a weak similarity with a DAPIN domain.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.