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Protein
Submitted name:

K2P10.1 potassium channel subunit

Gene

kcnk10b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-DRE-1299503. TWIK related potassium channel (TREK).

Names & Taxonomyi

Protein namesi
Submitted name:
K2P10.1 potassium channel subunitImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:kcnk10bImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 17

Organism-specific databases

ZFINiZDB-GENE-050420-31. kcnk10b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei73 – 94HelicalSequence analysisAdd BLAST22
Transmembranei155 – 174HelicalSequence analysisAdd BLAST20
Transmembranei186 – 204HelicalSequence analysisAdd BLAST19
Transmembranei240 – 258HelicalSequence analysisAdd BLAST19
Transmembranei270 – 288HelicalSequence analysisAdd BLAST19
Transmembranei303 – 325HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000067541.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 206Ion_trans_2InterPro annotationAdd BLAST58
Domaini247 – 326Ion_trans_2InterPro annotationAdd BLAST80

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili484 – 511Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000013106.
KOiK04920.
OMAiKQVNWDP.
OrthoDBiEOG091G0E3R.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003976. 2pore_dom_K_chnl_TREK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01499. TREKCHANNEL.

Sequencei

Sequence statusi: Complete.

C3VPM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPQKKPQSG AVQSSLVQAS VSAMQNPMGC ELKNGHCLLP RLSISSRSAS
60 70 80 90 100
VLTGMDSGAD GSALHSVMKW KTVLAVFVVV LSYLVCGGLA FQALEQPFES
110 120 130 140 150
IQKDSITQKK AQFLQKNPCV SHADLEALIK HAVEAVSTGV SPIGDASYNS
160 170 180 190 200
SQWDLGSAFF FAGTVITTIG YGNIAPSTEG GKIFCILYAI FGIPLFGFLL
210 220 230 240 250
AGVGDQLGTM FMKSILRVEK VFRQKHKQIS QTKIRVTSTI LFIIAGCIVF
260 270 280 290 300
VTIPAVFFKH TEGWSTLDAI YFVVITLTTI GIGDYVAGGD RKIEYMKWYK
310 320 330 340 350
PLVWFWILVG LAYFAAVLSM IGDWLRVLSK KTKEEVGQQV GGIKAHAVEW
360 370 380 390 400
KANVRAELRE TRRRLSGEIH DKLQRAATIR SMERRRLGLE QRAHSLDMLS
410 420 430 440 450
PEKRAVFASL DAGRFKTSSQ ESIDTKLNNL RLKAKCGEQQ TSSEENIFNR
460 470 480 490 500
FGSLTKLAKR NRSKDLRRNI QEDPTQIDEL DNVTLGEERQ EEEDEDQMEE
510 520 530 540 550
EEEEKVEKQA NTGFTCLPHY PEEPKQQNGL APAQVKEQER NKRLELKEHQ

P
Length:551
Mass (Da):61,496
Last modified:June 16, 2009 - v1
Checksum:iC38F009A92118E3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX927410 Genomic DNA. No translation available.
FJ888634 mRNA. Translation: ACP43543.1.
RefSeqiNP_001154871.1. NM_001161399.1.
UniGeneiDr.155304.

Genome annotation databases

EnsembliENSDART00000067542; ENSDARP00000067541; ENSDARG00000045956.
GeneIDi565629.
KEGGidre:565629.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX927410 Genomic DNA. No translation available.
FJ888634 mRNA. Translation: ACP43543.1.
RefSeqiNP_001154871.1. NM_001161399.1.
UniGeneiDr.155304.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000067541.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000067542; ENSDARP00000067541; ENSDARG00000045956.
GeneIDi565629.
KEGGidre:565629.

Organism-specific databases

CTDi565629.
ZFINiZDB-GENE-050420-31. kcnk10b.

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000013106.
KOiK04920.
OMAiKQVNWDP.
OrthoDBiEOG091G0E3R.
TreeFamiTF313947.

Enzyme and pathway databases

ReactomeiR-DRE-1299503. TWIK related potassium channel (TREK).

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003976. 2pore_dom_K_chnl_TREK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01499. TREKCHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiC3VPM9_DANRE
AccessioniPrimary (citable) accession number: C3VPM9
Entry historyi
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: November 2, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.