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Protein

Claudin

Gene

CLDN3

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.UniRule annotation

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
ClaudinUniRule annotation
Gene namesi
Name:CLDN3Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 29HelicalUniRule annotationAdd BLAST23
Transmembranei78 – 104HelicalUniRule annotationAdd BLAST27
Transmembranei116 – 139HelicalUniRule annotationAdd BLAST24
Transmembranei159 – 182HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Cell junction, Cell membraneUniRule annotationSAAS annotation, Membrane, Tight junctionUniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

InterProiView protein in InterPro
IPR006187. Claudin.
IPR003549. Claudin3.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiView protein in Pfam
PF00822. PMP22_Claudin. 1 hit.
PRINTSiPR01378. CLAUDIN3.
PROSITEiView protein in PROSITE
PS01346. CLAUDIN. 1 hit.

Sequencei

Sequence statusi: Complete.

C3VPJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMGLEIAGT SLAVMGWLST IVCCALPMWR VTAFIGSSII TAQITWEGLW
60 70 80 90 100
MNCVVQSTGQ MQCKVYDSLL ALPQDLQAAR ALIVVAILLA AFGLLVALVG
110 120 130 140 150
AQCTNCVQDD TAKAKITIVA GVLFLLAALL TLVPVSWSAN TIIRDFYNPL
160 170 180 190 200
VPDAQKREMG SALYVGWAAA ALQLLGGALL CCSCPPREKK YTPAKILYSA
210 220
PRSTVGPGTG TGTAYDRKDY V
Length:221
Mass (Da):23,466
Last modified:June 16, 2009 - v1
Checksum:iA798C63458BC203F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ887980 mRNA. Translation: ACP19336.1.
UniGeneiSsc.9102.
Ssc.93114.

Similar proteinsi

Entry informationi

Entry nameiC3VPJ5_PIG
AccessioniPrimary (citable) accession number: C3VPJ5
Entry historyiIntegrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: May 10, 2017
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)