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C3V005

- C3V005_9FLAV

UniProt

C3V005 - C3V005_9FLAV

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Protein
Submitted name:

Polyprotein

Gene
N/A
Organism
Chimeric Tick-borne encephalitis virus/Dengue virus 4
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotations

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP-dependent helicase activity Source: InterPro
  3. double-stranded RNA binding Source: InterPro
  4. mRNA (guanine-N7-)-methyltransferase activity Source: InterPro
  5. mRNA (nucleoside-2'-O-)-methyltransferase activity Source: InterPro
  6. RNA-directed RNA polymerase activity Source: UniProtKB-KW
  7. RNA helicase activity Source: InterPro
  8. serine-type endopeptidase activity Source: InterPro
  9. serine-type exopeptidase activity Source: InterPro
  10. structural molecule activity Source: InterPro

GO - Biological processi

  1. clathrin-mediated endocytosis of virus by host cell Source: UniProtKB-KW
  2. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  3. viral RNA genome replication Source: InterPro
  4. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HelicaseSAAS annotations, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymeraseSAAS annotations, Serine proteaseSAAS annotations, Transferase

Keywords - Biological processi

Fusion of virus membrane with host endosomal membraneSAAS annotations, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cellSAAS annotations, Viral penetration into host cytoplasm, Viral RNA replicationSAAS annotations, Virus entry into host cell

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-bindingSAAS annotations

Protein family/group databases

MEROPSiS07.001.

Names & Taxonomyi

Protein namesi
Submitted name:
PolyproteinImported
OrganismiChimeric Tick-borne encephalitis virus/Dengue virus 4Imported
Taxonomic identifieri638787 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageFlaviviridaeFlavivirus

Subcellular locationi

GO - Cellular componenti

  1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. viral capsid Source: UniProtKB-KW
  4. viral envelope Source: UniProtKB-KW
  5. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinSAAS annotations, Host membraneSAAS annotations, Membrane, Virion

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K4Relectron microscopy24.00A/B/C284-678[»]
ProteinModelPortaliC3V005.

Miscellaneous databases

EvolutionaryTraceiC3V005.

Family & Domainsi

Sequence similaritiesi

Contains RdRp catalytic domain.SAAS annotations
Contains helicase ATP-binding domain.SAAS annotations
Contains helicase C-terminal domain.SAAS annotations

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Family and domain databases

Gene3Di2.60.40.350. 1 hit.
2.60.98.10. 1 hit.
3.30.387.10. 1 hit.
3.30.67.10. 1 hit.
3.40.50.150. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR011492. DEAD_Flavivir.
IPR000069. Env_glycoprot_M_flavivir.
IPR013755. Flav_gly_cen_dom_subdom1.
IPR001122. Flavi_capsidC.
IPR026470. Flavi_E_Stem/Anchor_dom.
IPR001157. Flavi_NS1.
IPR000752. Flavi_NS2A.
IPR000487. Flavi_NS2B.
IPR000404. Flavi_NS4A.
IPR001528. Flavi_NS4B.
IPR002535. Flavi_propep.
IPR000336. Flavivir/Alphavir_Ig-like.
IPR001850. Flavivirus_NS3_S7.
IPR027287. Flavovir_Ig-like.
IPR014412. Gen_Poly_FLV.
IPR011998. Glycoprot_cen/dimer.
IPR013756. GlyE_cen_dom_subdom2.
IPR013754. GlyE_dim.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014756. Ig_E-set.
IPR026490. mRNA_cap_0/1_MeTrfase.
IPR027417. P-loop_NTPase.
IPR000208. RNA-dir_pol_flavivirus.
IPR007094. RNA-dir_pol_PSvirus.
IPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR029063. SAM-dependent_MTases-like.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF01003. Flavi_capsid. 1 hit.
PF07652. Flavi_DEAD. 1 hit.
PF02832. Flavi_glycop_C. 1 hit.
PF00869. Flavi_glycoprot. 1 hit.
PF01004. Flavi_M. 1 hit.
PF00948. Flavi_NS1. 1 hit.
PF01005. Flavi_NS2A. 1 hit.
PF01002. Flavi_NS2B. 1 hit.
PF01350. Flavi_NS4A. 1 hit.
PF01349. Flavi_NS4B. 1 hit.
PF00972. Flavi_NS5. 1 hit.
PF01570. Flavi_propep. 1 hit.
PF01728. FtsJ. 1 hit.
PF00949. Peptidase_S7. 1 hit.
[Graphical view]
PIRSFiPIRSF003817. Gen_Poly_FLV. 1 hit.
SMARTiSM00487. DEXDc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF53335. SSF53335. 1 hit.
SSF56983. SSF56983. 1 hit.
SSF81296. SSF81296. 1 hit.
TIGRFAMsiTIGR04240. flavi_E_stem. 1 hit.
PROSITEiPS51527. FLAVIVIRUS_NS2B. 1 hit.
PS51528. FLAVIVIRUS_NS3PRO. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
PS51591. RNA_CAP01_NS5_MT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3V005-1 [UniParc]FASTAAdd to Basket

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MNQRKKVVRP PFNMLKRERN RVSTPQGLVK RFSTGLFSGK GPLRMVLAFI     50
TFLRVLSIPP TAGILKRWGQ LKKNKAIKIL IGFRKEIGRM LNILNGRKRS 100
AVDWTGWLLV VVLLGVTLAA TVRKERDGTT VIRAEGKDAA TQVRVENGTC 150
VILATDMGSW CDDSLTYECV TIDQGEEPVD VDCFCRNVDG VYLEYGRCGK 200
QEGSRTRRSV LIPSHAQGDL TGRGHKWLEG DSLRTHLTRV EGWVWKNKVL 250
TLAVIAVVWL TVESVVTRVA VVVVLLCLAP VYASRCTHLE NRDFVTGTQG 300
TTRVTLVLEL GGCVTITAEG KPSMDVWLDS IYQENPAKTR EYCLHAKLSD 350
TKVAARCPTM GPATLAEEHQ SGTVCKRDQS DRGWGNHCGL FGKGSIVTCV 400
KASCEAKKKA TGHVYDANKI VYTVKVEPHT GDYVAANETH SGRKTASFTV 450
SSERTILTMG DYGDVSLLCR VASGVDLAQT VILELDKTSE HLPTAWQVHR 500
DWFNDLALPW KHEGAQNWNN AERLVEFGAP HAVKMDVYNL GDQTGVLLKS 550
LAGVPVAHID GTKYHLKSGH VTCEVGLEKL KMKGLTYTMC DKTKFTWKRI 600
PTDSGHDTVV MEVAFSGTKP CRIPVRAVAH GSPDVNVAML ITPNPTIENN 650
GGGFIEMQLP PGDNIIYVGE LSHQWFQKGS SIGRVFQKTR KGIERLTVIG 700
EHAWDFGSTG GFLTSVGKAL HTVLGGAFNS LFGGVGFLPK ILVGVVLAWL 750
GLNSRNTSMA MTCIAVGGIT LFLGFTVQAD MGCVASWSGK ELKCGSGIFV 800
VDNVHTWTEQ YKFQPESPAR LASAILNAHK DGVCGIRSTT RLENVMWKQI 850
TNELNYVLWE GGHDLTVVAG DVKGVLTKGK RALTPPVSDL KYSWKTWGKA 900
KIFTPEARNS TFLIDGPDTS ECPNERRAWN SLEVEDYGFG MFTTNIWMKF 950
REGSSEVCDH RLMSAAIKDQ KAVHADMGYW IESSKNQTWQ IEKASLIEVK 1000
TCLWPKTHTL WSNGVLESQM LIPKSYAGPF SQHNYRQGYA TQTVGPWHLG 1050
KLEIDFGECP GTTVTIQEDC DHRGPSLRTT TASGKLVTQW CCRSCTMPPL 1100
RFLGEDGCWY GMEIRPLSEK EENMVKSQVT AGQGTSETFS MGLLCLTLFV 1150
EECLRRRVTR KHMILVVVIT LCAIILGGLT WMDLLRALIM LGDTMSGRIG 1200
GQIHLAIMAV FKMSPGYVLG VFLRKLTSRE TALMVIGMAM TTVLSIPHDL 1250
MELIDGISLG LILLKIVTQF DNTQVGTLAL SLTFIRSTMP LVMAWRTIMA 1300
VLFVVTLIPL CRTSCLQKQS HWVEITALIL GAQALPVYLM TLMKGASRRS 1350
WPLNEGIMAV GLVSLLGSAL LKNDVPLAGP MVAGGLLLAA YVMSGSSADL 1400
SLEKAANVQW DEMADITGSS PIIEVKQDED GSFSIRDVEE TNMITLLVKL 1450
ALITVSGLYP LAIPVTMTLW YMWQVKTQRS GALWDVPSPA ATKKAALSEG 1500
VYRIMQRGLF GKTQVGVGIH MEGVFHTMWH VTRGSVICHE TGRLEPSWAD 1550
VRNDMISYGG GWRLGDKWDK EEDVQVLAIE PGKNPKHVQT KPGLFKTLTG 1600
EIGAVTLDFK PGTSGSPIIN RKGKVIGLYG NGVVTKSGDY VSAITQAERI 1650
GEPDYEVDED IFRKKRLTIM DLHPGAGKTK RILPSIVREA LKRRLRTLIL 1700
APTRVVAAEM EEALRGLPIR YQTPAVKSEH TGREIVDLMC HATFTTRLLS 1750
STRVPNYNLI VMDEAHFTDP SSVAARGYIS TRVEMGEAAA IFMTATPPGA 1800
TDPFPQSNSP IEDIEREIPE RSWNTGFDWI TDYQGKTVWF VPSIKAGNDI 1850
ANCLRKSGKK VIQLSRKTFD TEYPKTKLTD WDFVVTTDIS EMGANFRAGR 1900
VIDPRRCLKP VILPDGPERV ILAGPIPVTP ASAAQRRGRI GRNPAQEDDQ 1950
YVFSGDPLKN DEDHAHWTEA KMLLDNIYTP EGIIPTLFGP EREKTQAIDG 2000
EFRLRGEQRK TFVELMRRGD LPVWLSYKVA SAGISYKDRE WCFTGERNNQ 2050
ILEENMEVEI WTREGEKKKL RPRWLDARVY ADPMALKDFK EFASGRKSIT 2100
LDILTEIASL PTYLSSRAKL ALDNIVMLHT TERGGRAYQH ALNELPESLE 2150
TLMLVALLGA MTAGIFLFFM QGKGIGKLSM GLITIAVASG LLWVAEIQPQ 2200
WIAASIILEF FLMVLLIPEP EKQRTPQDNQ LIYVILTILT IIGLIAANEM 2250
GLIEKTKTDF GFYQVKTETT ILDVDLRPAS AWTLYAVATT ILTPMLRHTI 2300
ENTSANLSLA AIANQAAVLM GLGKGWPLHR MDLGVPLLAM GCYSQVNPTT 2350
LTASLVMLLV HYAIIGPGLQ AKATREAQKR TAAGIMKNPT VDGITVIDLE 2400
PISYDPKFEK QLGQVMLLVL CAGQLLLMRT TWAFCEVLTL ATGPILTLWE 2450
GNPGRFWNTT IAVSTANIFR GSYLAGAGLA FSLIKNAQTP RRGTGTTGET 2500
LGEKWKRQLN SLDRKEFEEY KRSGILEVDR TEAKSALKDG SKIKHAVSRG 2550
SSKIRWIVER GMVKPKGKVV DLGCGRGGWS YYMATLKNVT EVKGYTKGGP 2600
GHEEPIPMAT YGWNLVKLHS GVDVFYKPTE QVDTLLCDIG ESSSNPTIEE 2650
GRTLRVLKMV EPWLSSKPEF CIKVLNPYMP TVIEELEKLQ RKHGGNLVRC 2700
PLSRNSTHEM YWVSGASGNI VSSVNTTSKM LLNRFTTRHR KPTYEKDVDL 2750
GAGTRSVSTE TEKPDMTIIG RRLQRLQEEH KETWHYDQEN PYRTWAYHGS 2800
YEAPSTGSAS SMVNGVVKLL TKPWDVIPMV TQLAMTDTTP FGQQRVFKEK 2850
VDTRTPQPKP GTRMVMTTTA NWLWALLGKK KNPRLCTREE FISKVRSNAA 2900
IGAVFQEEQG WTSASEAVND SRFWELVDKE RALHQEGKCE SCVYNMMGKR 2950
EKKLGEFGRA KGSRAIWYMW LGARFLEFEA LGFLNEDHWF GRENSWSGVE 3000
GEGLHRLGYI LEEIDKKDGD LMYADDTAGW DTRITEDDLQ NEELITEQMA 3050
PHHKILAKAI FKLTYQNKVV KVLRPTPRGA VMDIISRKDQ RGSGQVGTYG 3100
LNTFTNMEVQ LIRQMEAEGV ITQDDMQNPK GLKERVEKWL KECGVDRLKR 3150
MAISGDDCVV KPLDERFGTS LLFLNDMGKV RKDIPQWEPS KGWKNWQEVP 3200
FCSHHFHKIF MKDGRSLVVP CRNQDELIGR ARISQGAGWS LRETACLGKA 3250
YAQMWSLMYF HRRDLRLASM AICSAVPTEW FPTSRTTWSI HAHHQWMTTE 3300
DMLKVWNRVW IEDNPNMTDK TPVHSWEDIP YLGKREDLWC GSLIGLSSRA 3350
TWAKNIHTAI TQVRNLIGKE EYVDYMPVMK RYSAPSESEG VL 3392
Length:3,392
Mass (Da):378,138
Last modified:June 16, 2009 - v1
Checksum:i0C7C70F2A34E4418
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FJ828987 Other RNA. Translation: ACO82049.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FJ828987 Other RNA. Translation: ACO82049.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1K4R electron microscopy 24.00 A/B/C 284-678 [» ]
ProteinModelPortali C3V005.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S07.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei C3V005.

Family and domain databases

Gene3Di 2.60.40.350. 1 hit.
2.60.98.10. 1 hit.
3.30.387.10. 1 hit.
3.30.67.10. 1 hit.
3.40.50.150. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR011492. DEAD_Flavivir.
IPR000069. Env_glycoprot_M_flavivir.
IPR013755. Flav_gly_cen_dom_subdom1.
IPR001122. Flavi_capsidC.
IPR026470. Flavi_E_Stem/Anchor_dom.
IPR001157. Flavi_NS1.
IPR000752. Flavi_NS2A.
IPR000487. Flavi_NS2B.
IPR000404. Flavi_NS4A.
IPR001528. Flavi_NS4B.
IPR002535. Flavi_propep.
IPR000336. Flavivir/Alphavir_Ig-like.
IPR001850. Flavivirus_NS3_S7.
IPR027287. Flavovir_Ig-like.
IPR014412. Gen_Poly_FLV.
IPR011998. Glycoprot_cen/dimer.
IPR013756. GlyE_cen_dom_subdom2.
IPR013754. GlyE_dim.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014756. Ig_E-set.
IPR026490. mRNA_cap_0/1_MeTrfase.
IPR027417. P-loop_NTPase.
IPR000208. RNA-dir_pol_flavivirus.
IPR007094. RNA-dir_pol_PSvirus.
IPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR029063. SAM-dependent_MTases-like.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF01003. Flavi_capsid. 1 hit.
PF07652. Flavi_DEAD. 1 hit.
PF02832. Flavi_glycop_C. 1 hit.
PF00869. Flavi_glycoprot. 1 hit.
PF01004. Flavi_M. 1 hit.
PF00948. Flavi_NS1. 1 hit.
PF01005. Flavi_NS2A. 1 hit.
PF01002. Flavi_NS2B. 1 hit.
PF01350. Flavi_NS4A. 1 hit.
PF01349. Flavi_NS4B. 1 hit.
PF00972. Flavi_NS5. 1 hit.
PF01570. Flavi_propep. 1 hit.
PF01728. FtsJ. 1 hit.
PF00949. Peptidase_S7. 1 hit.
[Graphical view ]
PIRSFi PIRSF003817. Gen_Poly_FLV. 1 hit.
SMARTi SM00487. DEXDc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF53335. SSF53335. 1 hit.
SSF56983. SSF56983. 1 hit.
SSF81296. SSF81296. 1 hit.
TIGRFAMsi TIGR04240. flavi_E_stem. 1 hit.
PROSITEi PS51527. FLAVIVIRUS_NS2B. 1 hit.
PS51528. FLAVIVIRUS_NS3PRO. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
PS51591. RNA_CAP01_NS5_MT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Construction and characterization of chimeric tick-borne encephalitis/dengue type 4 viruses."
    Pletnev A.G., Bray M., Huggins J., Lai C.J.
    Proc. Natl. Acad. Sci. U.S.A. 89:10532-10536(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Structure of dengue virus: implications for flavivirus organization, maturation, and fusion."
    Kuhn R.J., Zhang W., Rossmann M.G., Pletnev S.V., Corver J., Lenches E., Jones C.T., Mukhopadhyay S., Chipman P.R., Strauss E.G., Baker T.S., Strauss J.H.
    Cell 108:717-725(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY ELECTRON MICROSCOPY (24.00 ANGSTROMS) OF 284-678.
  3. Pletnev A.G.
    Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiC3V005_9FLAV
AccessioniPrimary (citable) accession number: C3V005
Entry historyi
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: July 9, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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