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C3V005

- C3V005_9FLAV

UniProt

C3V005 - C3V005_9FLAV

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Protein

Genome polyprotein

Gene
N/A
Organism
Chimeric Tick-borne encephalitis virus/Dengue virus 4
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP-dependent helicase activity Source: InterPro
  3. double-stranded RNA binding Source: InterPro
  4. mRNA (guanine-N7-)-methyltransferase activity Source: InterPro
  5. mRNA (nucleoside-2'-O-)-methyltransferase activity Source: InterPro
  6. RNA-directed RNA polymerase activity Source: UniProtKB-KW
  7. RNA helicase activity Source: InterPro
  8. serine-type endopeptidase activity Source: InterPro
  9. serine-type exopeptidase activity Source: InterPro
  10. structural molecule activity Source: InterPro

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. viral RNA genome replication Source: InterPro
  3. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HelicaseSAAS annotation, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymeraseSAAS annotation, Serine proteaseSAAS annotation, Transferase

Keywords - Biological processi

Fusion of virus membrane with host endosomal membraneSAAS annotation, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cellSAAS annotation, Viral penetration into host cytoplasm, Viral RNA replicationSAAS annotation, Virus entry into host cell

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-bindingSAAS annotation

Protein family/group databases

MEROPSiS07.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Genome polyproteinSAAS annotation
OrganismiChimeric Tick-borne encephalitis virus/Dengue virus 4Imported
Taxonomic identifieri638787 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageFlaviviridaeFlavivirus

Subcellular locationi

GO - Cellular componenti

  1. host cell membrane Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. viral capsid Source: UniProtKB-KW
  4. viral envelope Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinSAAS annotation, Host membraneSAAS annotation, Membrane, Virion

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K4Relectron microscopy24.00A/B/C284-678[»]
ProteinModelPortaliC3V005.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiC3V005.

Family & Domainsi

Sequence similaritiesi

Contains RdRp catalytic domain.SAAS annotation
Contains helicase ATP-binding domain.SAAS annotation
Contains helicase C-terminal domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Family and domain databases

Gene3Di2.60.40.350. 1 hit.
2.60.98.10. 1 hit.
3.30.387.10. 1 hit.
3.30.67.10. 1 hit.
3.40.50.150. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR011492. DEAD_Flavivir.
IPR000069. Env_glycoprot_M_flavivir.
IPR013755. Flav_gly_cen_dom_subdom1.
IPR001122. Flavi_capsidC.
IPR026470. Flavi_E_Stem/Anchor_dom.
IPR001157. Flavi_NS1.
IPR000752. Flavi_NS2A.
IPR000487. Flavi_NS2B.
IPR000404. Flavi_NS4A.
IPR001528. Flavi_NS4B.
IPR002535. Flavi_propep.
IPR000336. Flavivir/Alphavir_Ig-like.
IPR001850. Flavivirus_NS3_S7.
IPR027287. Flavovir_Ig-like.
IPR014412. Gen_Poly_FLV.
IPR011998. Glycoprot_cen/dimer.
IPR013756. GlyE_cen_dom_subdom2.
IPR013754. GlyE_dim.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014756. Ig_E-set.
IPR026490. mRNA_cap_0/1_MeTrfase.
IPR027417. P-loop_NTPase.
IPR000208. RNA-dir_pol_flavivirus.
IPR007094. RNA-dir_pol_PSvirus.
IPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR029063. SAM-dependent_MTases-like.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF01003. Flavi_capsid. 1 hit.
PF07652. Flavi_DEAD. 1 hit.
PF02832. Flavi_glycop_C. 1 hit.
PF00869. Flavi_glycoprot. 1 hit.
PF01004. Flavi_M. 1 hit.
PF00948. Flavi_NS1. 1 hit.
PF01005. Flavi_NS2A. 1 hit.
PF01002. Flavi_NS2B. 1 hit.
PF01350. Flavi_NS4A. 1 hit.
PF01349. Flavi_NS4B. 1 hit.
PF00972. Flavi_NS5. 1 hit.
PF01570. Flavi_propep. 1 hit.
PF01728. FtsJ. 1 hit.
PF00949. Peptidase_S7. 1 hit.
[Graphical view]
PIRSFiPIRSF003817. Gen_Poly_FLV. 1 hit.
SMARTiSM00487. DEXDc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF53335. SSF53335. 1 hit.
SSF56983. SSF56983. 1 hit.
SSF81296. SSF81296. 1 hit.
TIGRFAMsiTIGR04240. flavi_E_stem. 1 hit.
PROSITEiPS51527. FLAVIVIRUS_NS2B. 1 hit.
PS51528. FLAVIVIRUS_NS3PRO. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
PS51591. RNA_CAP01_NS5_MT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3V005-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNQRKKVVRP PFNMLKRERN RVSTPQGLVK RFSTGLFSGK GPLRMVLAFI
60 70 80 90 100
TFLRVLSIPP TAGILKRWGQ LKKNKAIKIL IGFRKEIGRM LNILNGRKRS
110 120 130 140 150
AVDWTGWLLV VVLLGVTLAA TVRKERDGTT VIRAEGKDAA TQVRVENGTC
160 170 180 190 200
VILATDMGSW CDDSLTYECV TIDQGEEPVD VDCFCRNVDG VYLEYGRCGK
210 220 230 240 250
QEGSRTRRSV LIPSHAQGDL TGRGHKWLEG DSLRTHLTRV EGWVWKNKVL
260 270 280 290 300
TLAVIAVVWL TVESVVTRVA VVVVLLCLAP VYASRCTHLE NRDFVTGTQG
310 320 330 340 350
TTRVTLVLEL GGCVTITAEG KPSMDVWLDS IYQENPAKTR EYCLHAKLSD
360 370 380 390 400
TKVAARCPTM GPATLAEEHQ SGTVCKRDQS DRGWGNHCGL FGKGSIVTCV
410 420 430 440 450
KASCEAKKKA TGHVYDANKI VYTVKVEPHT GDYVAANETH SGRKTASFTV
460 470 480 490 500
SSERTILTMG DYGDVSLLCR VASGVDLAQT VILELDKTSE HLPTAWQVHR
510 520 530 540 550
DWFNDLALPW KHEGAQNWNN AERLVEFGAP HAVKMDVYNL GDQTGVLLKS
560 570 580 590 600
LAGVPVAHID GTKYHLKSGH VTCEVGLEKL KMKGLTYTMC DKTKFTWKRI
610 620 630 640 650
PTDSGHDTVV MEVAFSGTKP CRIPVRAVAH GSPDVNVAML ITPNPTIENN
660 670 680 690 700
GGGFIEMQLP PGDNIIYVGE LSHQWFQKGS SIGRVFQKTR KGIERLTVIG
710 720 730 740 750
EHAWDFGSTG GFLTSVGKAL HTVLGGAFNS LFGGVGFLPK ILVGVVLAWL
760 770 780 790 800
GLNSRNTSMA MTCIAVGGIT LFLGFTVQAD MGCVASWSGK ELKCGSGIFV
810 820 830 840 850
VDNVHTWTEQ YKFQPESPAR LASAILNAHK DGVCGIRSTT RLENVMWKQI
860 870 880 890 900
TNELNYVLWE GGHDLTVVAG DVKGVLTKGK RALTPPVSDL KYSWKTWGKA
910 920 930 940 950
KIFTPEARNS TFLIDGPDTS ECPNERRAWN SLEVEDYGFG MFTTNIWMKF
960 970 980 990 1000
REGSSEVCDH RLMSAAIKDQ KAVHADMGYW IESSKNQTWQ IEKASLIEVK
1010 1020 1030 1040 1050
TCLWPKTHTL WSNGVLESQM LIPKSYAGPF SQHNYRQGYA TQTVGPWHLG
1060 1070 1080 1090 1100
KLEIDFGECP GTTVTIQEDC DHRGPSLRTT TASGKLVTQW CCRSCTMPPL
1110 1120 1130 1140 1150
RFLGEDGCWY GMEIRPLSEK EENMVKSQVT AGQGTSETFS MGLLCLTLFV
1160 1170 1180 1190 1200
EECLRRRVTR KHMILVVVIT LCAIILGGLT WMDLLRALIM LGDTMSGRIG
1210 1220 1230 1240 1250
GQIHLAIMAV FKMSPGYVLG VFLRKLTSRE TALMVIGMAM TTVLSIPHDL
1260 1270 1280 1290 1300
MELIDGISLG LILLKIVTQF DNTQVGTLAL SLTFIRSTMP LVMAWRTIMA
1310 1320 1330 1340 1350
VLFVVTLIPL CRTSCLQKQS HWVEITALIL GAQALPVYLM TLMKGASRRS
1360 1370 1380 1390 1400
WPLNEGIMAV GLVSLLGSAL LKNDVPLAGP MVAGGLLLAA YVMSGSSADL
1410 1420 1430 1440 1450
SLEKAANVQW DEMADITGSS PIIEVKQDED GSFSIRDVEE TNMITLLVKL
1460 1470 1480 1490 1500
ALITVSGLYP LAIPVTMTLW YMWQVKTQRS GALWDVPSPA ATKKAALSEG
1510 1520 1530 1540 1550
VYRIMQRGLF GKTQVGVGIH MEGVFHTMWH VTRGSVICHE TGRLEPSWAD
1560 1570 1580 1590 1600
VRNDMISYGG GWRLGDKWDK EEDVQVLAIE PGKNPKHVQT KPGLFKTLTG
1610 1620 1630 1640 1650
EIGAVTLDFK PGTSGSPIIN RKGKVIGLYG NGVVTKSGDY VSAITQAERI
1660 1670 1680 1690 1700
GEPDYEVDED IFRKKRLTIM DLHPGAGKTK RILPSIVREA LKRRLRTLIL
1710 1720 1730 1740 1750
APTRVVAAEM EEALRGLPIR YQTPAVKSEH TGREIVDLMC HATFTTRLLS
1760 1770 1780 1790 1800
STRVPNYNLI VMDEAHFTDP SSVAARGYIS TRVEMGEAAA IFMTATPPGA
1810 1820 1830 1840 1850
TDPFPQSNSP IEDIEREIPE RSWNTGFDWI TDYQGKTVWF VPSIKAGNDI
1860 1870 1880 1890 1900
ANCLRKSGKK VIQLSRKTFD TEYPKTKLTD WDFVVTTDIS EMGANFRAGR
1910 1920 1930 1940 1950
VIDPRRCLKP VILPDGPERV ILAGPIPVTP ASAAQRRGRI GRNPAQEDDQ
1960 1970 1980 1990 2000
YVFSGDPLKN DEDHAHWTEA KMLLDNIYTP EGIIPTLFGP EREKTQAIDG
2010 2020 2030 2040 2050
EFRLRGEQRK TFVELMRRGD LPVWLSYKVA SAGISYKDRE WCFTGERNNQ
2060 2070 2080 2090 2100
ILEENMEVEI WTREGEKKKL RPRWLDARVY ADPMALKDFK EFASGRKSIT
2110 2120 2130 2140 2150
LDILTEIASL PTYLSSRAKL ALDNIVMLHT TERGGRAYQH ALNELPESLE
2160 2170 2180 2190 2200
TLMLVALLGA MTAGIFLFFM QGKGIGKLSM GLITIAVASG LLWVAEIQPQ
2210 2220 2230 2240 2250
WIAASIILEF FLMVLLIPEP EKQRTPQDNQ LIYVILTILT IIGLIAANEM
2260 2270 2280 2290 2300
GLIEKTKTDF GFYQVKTETT ILDVDLRPAS AWTLYAVATT ILTPMLRHTI
2310 2320 2330 2340 2350
ENTSANLSLA AIANQAAVLM GLGKGWPLHR MDLGVPLLAM GCYSQVNPTT
2360 2370 2380 2390 2400
LTASLVMLLV HYAIIGPGLQ AKATREAQKR TAAGIMKNPT VDGITVIDLE
2410 2420 2430 2440 2450
PISYDPKFEK QLGQVMLLVL CAGQLLLMRT TWAFCEVLTL ATGPILTLWE
2460 2470 2480 2490 2500
GNPGRFWNTT IAVSTANIFR GSYLAGAGLA FSLIKNAQTP RRGTGTTGET
2510 2520 2530 2540 2550
LGEKWKRQLN SLDRKEFEEY KRSGILEVDR TEAKSALKDG SKIKHAVSRG
2560 2570 2580 2590 2600
SSKIRWIVER GMVKPKGKVV DLGCGRGGWS YYMATLKNVT EVKGYTKGGP
2610 2620 2630 2640 2650
GHEEPIPMAT YGWNLVKLHS GVDVFYKPTE QVDTLLCDIG ESSSNPTIEE
2660 2670 2680 2690 2700
GRTLRVLKMV EPWLSSKPEF CIKVLNPYMP TVIEELEKLQ RKHGGNLVRC
2710 2720 2730 2740 2750
PLSRNSTHEM YWVSGASGNI VSSVNTTSKM LLNRFTTRHR KPTYEKDVDL
2760 2770 2780 2790 2800
GAGTRSVSTE TEKPDMTIIG RRLQRLQEEH KETWHYDQEN PYRTWAYHGS
2810 2820 2830 2840 2850
YEAPSTGSAS SMVNGVVKLL TKPWDVIPMV TQLAMTDTTP FGQQRVFKEK
2860 2870 2880 2890 2900
VDTRTPQPKP GTRMVMTTTA NWLWALLGKK KNPRLCTREE FISKVRSNAA
2910 2920 2930 2940 2950
IGAVFQEEQG WTSASEAVND SRFWELVDKE RALHQEGKCE SCVYNMMGKR
2960 2970 2980 2990 3000
EKKLGEFGRA KGSRAIWYMW LGARFLEFEA LGFLNEDHWF GRENSWSGVE
3010 3020 3030 3040 3050
GEGLHRLGYI LEEIDKKDGD LMYADDTAGW DTRITEDDLQ NEELITEQMA
3060 3070 3080 3090 3100
PHHKILAKAI FKLTYQNKVV KVLRPTPRGA VMDIISRKDQ RGSGQVGTYG
3110 3120 3130 3140 3150
LNTFTNMEVQ LIRQMEAEGV ITQDDMQNPK GLKERVEKWL KECGVDRLKR
3160 3170 3180 3190 3200
MAISGDDCVV KPLDERFGTS LLFLNDMGKV RKDIPQWEPS KGWKNWQEVP
3210 3220 3230 3240 3250
FCSHHFHKIF MKDGRSLVVP CRNQDELIGR ARISQGAGWS LRETACLGKA
3260 3270 3280 3290 3300
YAQMWSLMYF HRRDLRLASM AICSAVPTEW FPTSRTTWSI HAHHQWMTTE
3310 3320 3330 3340 3350
DMLKVWNRVW IEDNPNMTDK TPVHSWEDIP YLGKREDLWC GSLIGLSSRA
3360 3370 3380 3390
TWAKNIHTAI TQVRNLIGKE EYVDYMPVMK RYSAPSESEG VL
Length:3,392
Mass (Da):378,138
Last modified:June 16, 2009 - v1
Checksum:i0C7C70F2A34E4418
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ828987 Other RNA. Translation: ACO82049.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ828987 Other RNA. Translation: ACO82049.1 .

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1K4R electron microscopy 24.00 A/B/C 284-678 [» ]
ProteinModelPortali C3V005.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S07.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei C3V005.

Family and domain databases

Gene3Di 2.60.40.350. 1 hit.
2.60.98.10. 1 hit.
3.30.387.10. 1 hit.
3.30.67.10. 1 hit.
3.40.50.150. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR011492. DEAD_Flavivir.
IPR000069. Env_glycoprot_M_flavivir.
IPR013755. Flav_gly_cen_dom_subdom1.
IPR001122. Flavi_capsidC.
IPR026470. Flavi_E_Stem/Anchor_dom.
IPR001157. Flavi_NS1.
IPR000752. Flavi_NS2A.
IPR000487. Flavi_NS2B.
IPR000404. Flavi_NS4A.
IPR001528. Flavi_NS4B.
IPR002535. Flavi_propep.
IPR000336. Flavivir/Alphavir_Ig-like.
IPR001850. Flavivirus_NS3_S7.
IPR027287. Flavovir_Ig-like.
IPR014412. Gen_Poly_FLV.
IPR011998. Glycoprot_cen/dimer.
IPR013756. GlyE_cen_dom_subdom2.
IPR013754. GlyE_dim.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014756. Ig_E-set.
IPR026490. mRNA_cap_0/1_MeTrfase.
IPR027417. P-loop_NTPase.
IPR000208. RNA-dir_pol_flavivirus.
IPR007094. RNA-dir_pol_PSvirus.
IPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR029063. SAM-dependent_MTases-like.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF01003. Flavi_capsid. 1 hit.
PF07652. Flavi_DEAD. 1 hit.
PF02832. Flavi_glycop_C. 1 hit.
PF00869. Flavi_glycoprot. 1 hit.
PF01004. Flavi_M. 1 hit.
PF00948. Flavi_NS1. 1 hit.
PF01005. Flavi_NS2A. 1 hit.
PF01002. Flavi_NS2B. 1 hit.
PF01350. Flavi_NS4A. 1 hit.
PF01349. Flavi_NS4B. 1 hit.
PF00972. Flavi_NS5. 1 hit.
PF01570. Flavi_propep. 1 hit.
PF01728. FtsJ. 1 hit.
PF00949. Peptidase_S7. 1 hit.
[Graphical view ]
PIRSFi PIRSF003817. Gen_Poly_FLV. 1 hit.
SMARTi SM00487. DEXDc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF53335. SSF53335. 1 hit.
SSF56983. SSF56983. 1 hit.
SSF81296. SSF81296. 1 hit.
TIGRFAMsi TIGR04240. flavi_E_stem. 1 hit.
PROSITEi PS51527. FLAVIVIRUS_NS2B. 1 hit.
PS51528. FLAVIVIRUS_NS3PRO. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
PS51591. RNA_CAP01_NS5_MT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Construction and characterization of chimeric tick-borne encephalitis/dengue type 4 viruses."
    Pletnev A.G., Bray M., Huggins J., Lai C.J.
    Proc. Natl. Acad. Sci. U.S.A. 89:10532-10536(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Structure of dengue virus: implications for flavivirus organization, maturation, and fusion."
    Kuhn R.J., Zhang W., Rossmann M.G., Pletnev S.V., Corver J., Lenches E., Jones C.T., Mukhopadhyay S., Chipman P.R., Strauss E.G., Baker T.S., Strauss J.H.
    Cell 108:717-725(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY ELECTRON MICROSCOPY (24.00 ANGSTROMS) OF 284-678, ACTIVE SITE.
  3. Pletnev A.G.
    Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiC3V005_9FLAV
AccessioniPrimary (citable) accession number: C3V005
Entry historyi
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: November 26, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3