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C3V005

- C3V005_9FLAV

UniProt

C3V005 - C3V005_9FLAV

Protein
Submitted name:

Polyprotein

Gene
N/A
Organism
Chimeric Tick-borne encephalitis virus/Dengue virus 4
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ATP-dependent helicase activity Source: InterPro
    3. double-stranded RNA binding Source: InterPro
    4. mRNA (guanine-N7-)-methyltransferase activity Source: InterPro
    5. mRNA (nucleoside-2'-O-)-methyltransferase activity Source: InterPro
    6. RNA-directed RNA polymerase activity Source: UniProtKB-KW
    7. RNA helicase activity Source: InterPro
    8. serine-type endopeptidase activity Source: InterPro
    9. serine-type exopeptidase activity Source: InterPro
    10. structural molecule activity Source: InterPro

    GO - Biological processi

    1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
    2. viral RNA genome replication Source: InterPro
    3. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Molecular functioni

    HelicaseSAAS annotation, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymeraseSAAS annotation, Serine proteaseSAAS annotation, Transferase

    Keywords - Biological processi

    Fusion of virus membrane with host endosomal membraneSAAS annotation, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cellSAAS annotation, Viral penetration into host cytoplasm, Viral RNA replicationSAAS annotation, Virus entry into host cell

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-bindingSAAS annotation

    Protein family/group databases

    MEROPSiS07.001.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    PolyproteinImported
    OrganismiChimeric Tick-borne encephalitis virus/Dengue virus 4Imported
    Taxonomic identifieri638787 [NCBI]
    Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageFlaviviridaeFlavivirus

    Subcellular locationi

    GO - Cellular componenti

    1. host cell membrane Source: UniProtKB-KW
    2. integral component of membrane Source: UniProtKB-KW
    3. viral capsid Source: UniProtKB-KW
    4. viral envelope Source: InterPro

    Keywords - Cellular componenti

    Capsid proteinSAAS annotation, Host membraneSAAS annotation, Membrane, Virion

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1K4Relectron microscopy24.00A/B/C284-678[»]
    ProteinModelPortaliC3V005.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiC3V005.

    Family & Domainsi

    Sequence similaritiesi

    Contains RdRp catalytic domain.SAAS annotation
    Contains helicase ATP-binding domain.SAAS annotation
    Contains helicase C-terminal domain.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Family and domain databases

    Gene3Di2.60.40.350. 1 hit.
    2.60.98.10. 1 hit.
    3.30.387.10. 1 hit.
    3.30.67.10. 1 hit.
    3.40.50.150. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR011492. DEAD_Flavivir.
    IPR000069. Env_glycoprot_M_flavivir.
    IPR013755. Flav_gly_cen_dom_subdom1.
    IPR001122. Flavi_capsidC.
    IPR026470. Flavi_E_Stem/Anchor_dom.
    IPR001157. Flavi_NS1.
    IPR000752. Flavi_NS2A.
    IPR000487. Flavi_NS2B.
    IPR000404. Flavi_NS4A.
    IPR001528. Flavi_NS4B.
    IPR002535. Flavi_propep.
    IPR000336. Flavivir/Alphavir_Ig-like.
    IPR001850. Flavivirus_NS3_S7.
    IPR027287. Flavovir_Ig-like.
    IPR014412. Gen_Poly_FLV.
    IPR011998. Glycoprot_cen/dimer.
    IPR013756. GlyE_cen_dom_subdom2.
    IPR013754. GlyE_dim.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR014756. Ig_E-set.
    IPR026490. mRNA_cap_0/1_MeTrfase.
    IPR027417. P-loop_NTPase.
    IPR000208. RNA-dir_pol_flavivirus.
    IPR007094. RNA-dir_pol_PSvirus.
    IPR002877. rRNA_MeTrfase_FtsJ_dom.
    IPR029063. SAM-dependent_MTases-like.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF01003. Flavi_capsid. 1 hit.
    PF07652. Flavi_DEAD. 1 hit.
    PF02832. Flavi_glycop_C. 1 hit.
    PF00869. Flavi_glycoprot. 1 hit.
    PF01004. Flavi_M. 1 hit.
    PF00948. Flavi_NS1. 1 hit.
    PF01005. Flavi_NS2A. 1 hit.
    PF01002. Flavi_NS2B. 1 hit.
    PF01350. Flavi_NS4A. 1 hit.
    PF01349. Flavi_NS4B. 1 hit.
    PF00972. Flavi_NS5. 1 hit.
    PF01570. Flavi_propep. 1 hit.
    PF01728. FtsJ. 1 hit.
    PF00949. Peptidase_S7. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003817. Gen_Poly_FLV. 1 hit.
    SMARTiSM00487. DEXDc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    SSF52540. SSF52540. 2 hits.
    SSF53335. SSF53335. 1 hit.
    SSF56983. SSF56983. 1 hit.
    SSF81296. SSF81296. 1 hit.
    TIGRFAMsiTIGR04240. flavi_E_stem. 1 hit.
    PROSITEiPS51527. FLAVIVIRUS_NS2B. 1 hit.
    PS51528. FLAVIVIRUS_NS3PRO. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS50507. RDRP_SSRNA_POS. 1 hit.
    PS51591. RNA_CAP01_NS5_MT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C3V005-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNQRKKVVRP PFNMLKRERN RVSTPQGLVK RFSTGLFSGK GPLRMVLAFI     50
    TFLRVLSIPP TAGILKRWGQ LKKNKAIKIL IGFRKEIGRM LNILNGRKRS 100
    AVDWTGWLLV VVLLGVTLAA TVRKERDGTT VIRAEGKDAA TQVRVENGTC 150
    VILATDMGSW CDDSLTYECV TIDQGEEPVD VDCFCRNVDG VYLEYGRCGK 200
    QEGSRTRRSV LIPSHAQGDL TGRGHKWLEG DSLRTHLTRV EGWVWKNKVL 250
    TLAVIAVVWL TVESVVTRVA VVVVLLCLAP VYASRCTHLE NRDFVTGTQG 300
    TTRVTLVLEL GGCVTITAEG KPSMDVWLDS IYQENPAKTR EYCLHAKLSD 350
    TKVAARCPTM GPATLAEEHQ SGTVCKRDQS DRGWGNHCGL FGKGSIVTCV 400
    KASCEAKKKA TGHVYDANKI VYTVKVEPHT GDYVAANETH SGRKTASFTV 450
    SSERTILTMG DYGDVSLLCR VASGVDLAQT VILELDKTSE HLPTAWQVHR 500
    DWFNDLALPW KHEGAQNWNN AERLVEFGAP HAVKMDVYNL GDQTGVLLKS 550
    LAGVPVAHID GTKYHLKSGH VTCEVGLEKL KMKGLTYTMC DKTKFTWKRI 600
    PTDSGHDTVV MEVAFSGTKP CRIPVRAVAH GSPDVNVAML ITPNPTIENN 650
    GGGFIEMQLP PGDNIIYVGE LSHQWFQKGS SIGRVFQKTR KGIERLTVIG 700
    EHAWDFGSTG GFLTSVGKAL HTVLGGAFNS LFGGVGFLPK ILVGVVLAWL 750
    GLNSRNTSMA MTCIAVGGIT LFLGFTVQAD MGCVASWSGK ELKCGSGIFV 800
    VDNVHTWTEQ YKFQPESPAR LASAILNAHK DGVCGIRSTT RLENVMWKQI 850
    TNELNYVLWE GGHDLTVVAG DVKGVLTKGK RALTPPVSDL KYSWKTWGKA 900
    KIFTPEARNS TFLIDGPDTS ECPNERRAWN SLEVEDYGFG MFTTNIWMKF 950
    REGSSEVCDH RLMSAAIKDQ KAVHADMGYW IESSKNQTWQ IEKASLIEVK 1000
    TCLWPKTHTL WSNGVLESQM LIPKSYAGPF SQHNYRQGYA TQTVGPWHLG 1050
    KLEIDFGECP GTTVTIQEDC DHRGPSLRTT TASGKLVTQW CCRSCTMPPL 1100
    RFLGEDGCWY GMEIRPLSEK EENMVKSQVT AGQGTSETFS MGLLCLTLFV 1150
    EECLRRRVTR KHMILVVVIT LCAIILGGLT WMDLLRALIM LGDTMSGRIG 1200
    GQIHLAIMAV FKMSPGYVLG VFLRKLTSRE TALMVIGMAM TTVLSIPHDL 1250
    MELIDGISLG LILLKIVTQF DNTQVGTLAL SLTFIRSTMP LVMAWRTIMA 1300
    VLFVVTLIPL CRTSCLQKQS HWVEITALIL GAQALPVYLM TLMKGASRRS 1350
    WPLNEGIMAV GLVSLLGSAL LKNDVPLAGP MVAGGLLLAA YVMSGSSADL 1400
    SLEKAANVQW DEMADITGSS PIIEVKQDED GSFSIRDVEE TNMITLLVKL 1450
    ALITVSGLYP LAIPVTMTLW YMWQVKTQRS GALWDVPSPA ATKKAALSEG 1500
    VYRIMQRGLF GKTQVGVGIH MEGVFHTMWH VTRGSVICHE TGRLEPSWAD 1550
    VRNDMISYGG GWRLGDKWDK EEDVQVLAIE PGKNPKHVQT KPGLFKTLTG 1600
    EIGAVTLDFK PGTSGSPIIN RKGKVIGLYG NGVVTKSGDY VSAITQAERI 1650
    GEPDYEVDED IFRKKRLTIM DLHPGAGKTK RILPSIVREA LKRRLRTLIL 1700
    APTRVVAAEM EEALRGLPIR YQTPAVKSEH TGREIVDLMC HATFTTRLLS 1750
    STRVPNYNLI VMDEAHFTDP SSVAARGYIS TRVEMGEAAA IFMTATPPGA 1800
    TDPFPQSNSP IEDIEREIPE RSWNTGFDWI TDYQGKTVWF VPSIKAGNDI 1850
    ANCLRKSGKK VIQLSRKTFD TEYPKTKLTD WDFVVTTDIS EMGANFRAGR 1900
    VIDPRRCLKP VILPDGPERV ILAGPIPVTP ASAAQRRGRI GRNPAQEDDQ 1950
    YVFSGDPLKN DEDHAHWTEA KMLLDNIYTP EGIIPTLFGP EREKTQAIDG 2000
    EFRLRGEQRK TFVELMRRGD LPVWLSYKVA SAGISYKDRE WCFTGERNNQ 2050
    ILEENMEVEI WTREGEKKKL RPRWLDARVY ADPMALKDFK EFASGRKSIT 2100
    LDILTEIASL PTYLSSRAKL ALDNIVMLHT TERGGRAYQH ALNELPESLE 2150
    TLMLVALLGA MTAGIFLFFM QGKGIGKLSM GLITIAVASG LLWVAEIQPQ 2200
    WIAASIILEF FLMVLLIPEP EKQRTPQDNQ LIYVILTILT IIGLIAANEM 2250
    GLIEKTKTDF GFYQVKTETT ILDVDLRPAS AWTLYAVATT ILTPMLRHTI 2300
    ENTSANLSLA AIANQAAVLM GLGKGWPLHR MDLGVPLLAM GCYSQVNPTT 2350
    LTASLVMLLV HYAIIGPGLQ AKATREAQKR TAAGIMKNPT VDGITVIDLE 2400
    PISYDPKFEK QLGQVMLLVL CAGQLLLMRT TWAFCEVLTL ATGPILTLWE 2450
    GNPGRFWNTT IAVSTANIFR GSYLAGAGLA FSLIKNAQTP RRGTGTTGET 2500
    LGEKWKRQLN SLDRKEFEEY KRSGILEVDR TEAKSALKDG SKIKHAVSRG 2550
    SSKIRWIVER GMVKPKGKVV DLGCGRGGWS YYMATLKNVT EVKGYTKGGP 2600
    GHEEPIPMAT YGWNLVKLHS GVDVFYKPTE QVDTLLCDIG ESSSNPTIEE 2650
    GRTLRVLKMV EPWLSSKPEF CIKVLNPYMP TVIEELEKLQ RKHGGNLVRC 2700
    PLSRNSTHEM YWVSGASGNI VSSVNTTSKM LLNRFTTRHR KPTYEKDVDL 2750
    GAGTRSVSTE TEKPDMTIIG RRLQRLQEEH KETWHYDQEN PYRTWAYHGS 2800
    YEAPSTGSAS SMVNGVVKLL TKPWDVIPMV TQLAMTDTTP FGQQRVFKEK 2850
    VDTRTPQPKP GTRMVMTTTA NWLWALLGKK KNPRLCTREE FISKVRSNAA 2900
    IGAVFQEEQG WTSASEAVND SRFWELVDKE RALHQEGKCE SCVYNMMGKR 2950
    EKKLGEFGRA KGSRAIWYMW LGARFLEFEA LGFLNEDHWF GRENSWSGVE 3000
    GEGLHRLGYI LEEIDKKDGD LMYADDTAGW DTRITEDDLQ NEELITEQMA 3050
    PHHKILAKAI FKLTYQNKVV KVLRPTPRGA VMDIISRKDQ RGSGQVGTYG 3100
    LNTFTNMEVQ LIRQMEAEGV ITQDDMQNPK GLKERVEKWL KECGVDRLKR 3150
    MAISGDDCVV KPLDERFGTS LLFLNDMGKV RKDIPQWEPS KGWKNWQEVP 3200
    FCSHHFHKIF MKDGRSLVVP CRNQDELIGR ARISQGAGWS LRETACLGKA 3250
    YAQMWSLMYF HRRDLRLASM AICSAVPTEW FPTSRTTWSI HAHHQWMTTE 3300
    DMLKVWNRVW IEDNPNMTDK TPVHSWEDIP YLGKREDLWC GSLIGLSSRA 3350
    TWAKNIHTAI TQVRNLIGKE EYVDYMPVMK RYSAPSESEG VL 3392
    Length:3,392
    Mass (Da):378,138
    Last modified:June 16, 2009 - v1
    Checksum:i0C7C70F2A34E4418
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FJ828987 Other RNA. Translation: ACO82049.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FJ828987 Other RNA. Translation: ACO82049.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1K4R electron microscopy 24.00 A/B/C 284-678 [» ]
    ProteinModelPortali C3V005.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S07.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei C3V005.

    Family and domain databases

    Gene3Di 2.60.40.350. 1 hit.
    2.60.98.10. 1 hit.
    3.30.387.10. 1 hit.
    3.30.67.10. 1 hit.
    3.40.50.150. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR011492. DEAD_Flavivir.
    IPR000069. Env_glycoprot_M_flavivir.
    IPR013755. Flav_gly_cen_dom_subdom1.
    IPR001122. Flavi_capsidC.
    IPR026470. Flavi_E_Stem/Anchor_dom.
    IPR001157. Flavi_NS1.
    IPR000752. Flavi_NS2A.
    IPR000487. Flavi_NS2B.
    IPR000404. Flavi_NS4A.
    IPR001528. Flavi_NS4B.
    IPR002535. Flavi_propep.
    IPR000336. Flavivir/Alphavir_Ig-like.
    IPR001850. Flavivirus_NS3_S7.
    IPR027287. Flavovir_Ig-like.
    IPR014412. Gen_Poly_FLV.
    IPR011998. Glycoprot_cen/dimer.
    IPR013756. GlyE_cen_dom_subdom2.
    IPR013754. GlyE_dim.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR014756. Ig_E-set.
    IPR026490. mRNA_cap_0/1_MeTrfase.
    IPR027417. P-loop_NTPase.
    IPR000208. RNA-dir_pol_flavivirus.
    IPR007094. RNA-dir_pol_PSvirus.
    IPR002877. rRNA_MeTrfase_FtsJ_dom.
    IPR029063. SAM-dependent_MTases-like.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF01003. Flavi_capsid. 1 hit.
    PF07652. Flavi_DEAD. 1 hit.
    PF02832. Flavi_glycop_C. 1 hit.
    PF00869. Flavi_glycoprot. 1 hit.
    PF01004. Flavi_M. 1 hit.
    PF00948. Flavi_NS1. 1 hit.
    PF01005. Flavi_NS2A. 1 hit.
    PF01002. Flavi_NS2B. 1 hit.
    PF01350. Flavi_NS4A. 1 hit.
    PF01349. Flavi_NS4B. 1 hit.
    PF00972. Flavi_NS5. 1 hit.
    PF01570. Flavi_propep. 1 hit.
    PF01728. FtsJ. 1 hit.
    PF00949. Peptidase_S7. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003817. Gen_Poly_FLV. 1 hit.
    SMARTi SM00487. DEXDc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    SSF52540. SSF52540. 2 hits.
    SSF53335. SSF53335. 1 hit.
    SSF56983. SSF56983. 1 hit.
    SSF81296. SSF81296. 1 hit.
    TIGRFAMsi TIGR04240. flavi_E_stem. 1 hit.
    PROSITEi PS51527. FLAVIVIRUS_NS2B. 1 hit.
    PS51528. FLAVIVIRUS_NS3PRO. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS50507. RDRP_SSRNA_POS. 1 hit.
    PS51591. RNA_CAP01_NS5_MT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Construction and characterization of chimeric tick-borne encephalitis/dengue type 4 viruses."
      Pletnev A.G., Bray M., Huggins J., Lai C.J.
      Proc. Natl. Acad. Sci. U.S.A. 89:10532-10536(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Structure of dengue virus: implications for flavivirus organization, maturation, and fusion."
      Kuhn R.J., Zhang W., Rossmann M.G., Pletnev S.V., Corver J., Lenches E., Jones C.T., Mukhopadhyay S., Chipman P.R., Strauss E.G., Baker T.S., Strauss J.H.
      Cell 108:717-725(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY ELECTRON MICROSCOPY (24.00 ANGSTROMS) OF 284-678.
    3. Pletnev A.G.
      Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiC3V005_9FLAV
    AccessioniPrimary (citable) accession number: C3V005
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 16, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3