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C3V005 (C3V005_9FLAV) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Protein attributes

Sequence length3392 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). SAAS SAAS007094

Sequence similarities

Contains 1 RdRp catalytic domain.

Contains RdRp catalytic domain. SAAS SAAS007094

Contains helicase ATP-binding domain. SAAS SAAS007094

Contains helicase C-terminal domain. SAAS SAAS007094

Ontologies

Keywords
   Biological processFusion of virus membrane with host endosomal membrane SAAS SAAS000336
Fusion of virus membrane with host membrane
Host-virus interaction
Viral attachment to host cell SAAS SAAS011998
Viral penetration into host cytoplasm
Viral RNA replication SAAS SAAS007094
Virus entry into host cell
   Cellular componentCapsid protein SAAS SAAS011998
Host membrane SAAS SAAS011998
Membrane
Virion
   DomainTransmembrane
Transmembrane helix SAAS SAAS011998
   LigandATP-binding
Nucleotide-binding
RNA-binding SAAS SAAS007094
   Molecular functionHelicase SAAS SAAS007094
Hydrolase
Nucleotidyltransferase
Protease
RNA-directed RNA polymerase SAAS SAAS007094
Serine protease SAAS SAAS000336
Transferase
   PTMDisulfide bond SAAS SAAS000336
   Technical term3D-structure PDB 1K4R
Gene Ontology (GO)
   Biological_processclathrin-mediated endocytosis of virus by host cell

Inferred from electronic annotation. Source: UniProtKB-KW

fusion of virus membrane with host endosome membrane

Inferred from electronic annotation. Source: UniProtKB-KW

viral RNA genome replication

Inferred from electronic annotation. Source: InterPro

virion attachment to host cell

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthost cell endoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

viral capsid

Inferred from electronic annotation. Source: UniProtKB-KW

viral envelope

Inferred from electronic annotation. Source: UniProtKB-KW

virion membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATP-dependent helicase activity

Inferred from electronic annotation. Source: InterPro

RNA helicase activity

Inferred from electronic annotation. Source: InterPro

RNA-directed RNA polymerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

double-stranded RNA binding

Inferred from electronic annotation. Source: InterPro

mRNA (guanine-N7-)-methyltransferase activity

Inferred from electronic annotation. Source: InterPro

mRNA (nucleoside-2'-O-)-methyltransferase activity

Inferred from electronic annotation. Source: InterPro

serine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

serine-type exopeptidase activity

Inferred from electronic annotation. Source: InterPro

structural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
C3V005 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: 0C7C70F2A34E4418

FASTA3,392378,138
        10         20         30         40         50         60 
MNQRKKVVRP PFNMLKRERN RVSTPQGLVK RFSTGLFSGK GPLRMVLAFI TFLRVLSIPP 

        70         80         90        100        110        120 
TAGILKRWGQ LKKNKAIKIL IGFRKEIGRM LNILNGRKRS AVDWTGWLLV VVLLGVTLAA 

       130        140        150        160        170        180 
TVRKERDGTT VIRAEGKDAA TQVRVENGTC VILATDMGSW CDDSLTYECV TIDQGEEPVD 

       190        200        210        220        230        240 
VDCFCRNVDG VYLEYGRCGK QEGSRTRRSV LIPSHAQGDL TGRGHKWLEG DSLRTHLTRV 

       250        260        270        280        290        300 
EGWVWKNKVL TLAVIAVVWL TVESVVTRVA VVVVLLCLAP VYASRCTHLE NRDFVTGTQG 

       310        320        330        340        350        360 
TTRVTLVLEL GGCVTITAEG KPSMDVWLDS IYQENPAKTR EYCLHAKLSD TKVAARCPTM 

       370        380        390        400        410        420 
GPATLAEEHQ SGTVCKRDQS DRGWGNHCGL FGKGSIVTCV KASCEAKKKA TGHVYDANKI 

       430        440        450        460        470        480 
VYTVKVEPHT GDYVAANETH SGRKTASFTV SSERTILTMG DYGDVSLLCR VASGVDLAQT 

       490        500        510        520        530        540 
VILELDKTSE HLPTAWQVHR DWFNDLALPW KHEGAQNWNN AERLVEFGAP HAVKMDVYNL 

       550        560        570        580        590        600 
GDQTGVLLKS LAGVPVAHID GTKYHLKSGH VTCEVGLEKL KMKGLTYTMC DKTKFTWKRI 

       610        620        630        640        650        660 
PTDSGHDTVV MEVAFSGTKP CRIPVRAVAH GSPDVNVAML ITPNPTIENN GGGFIEMQLP 

       670        680        690        700        710        720 
PGDNIIYVGE LSHQWFQKGS SIGRVFQKTR KGIERLTVIG EHAWDFGSTG GFLTSVGKAL 

       730        740        750        760        770        780 
HTVLGGAFNS LFGGVGFLPK ILVGVVLAWL GLNSRNTSMA MTCIAVGGIT LFLGFTVQAD 

       790        800        810        820        830        840 
MGCVASWSGK ELKCGSGIFV VDNVHTWTEQ YKFQPESPAR LASAILNAHK DGVCGIRSTT 

       850        860        870        880        890        900 
RLENVMWKQI TNELNYVLWE GGHDLTVVAG DVKGVLTKGK RALTPPVSDL KYSWKTWGKA 

       910        920        930        940        950        960 
KIFTPEARNS TFLIDGPDTS ECPNERRAWN SLEVEDYGFG MFTTNIWMKF REGSSEVCDH 

       970        980        990       1000       1010       1020 
RLMSAAIKDQ KAVHADMGYW IESSKNQTWQ IEKASLIEVK TCLWPKTHTL WSNGVLESQM 

      1030       1040       1050       1060       1070       1080 
LIPKSYAGPF SQHNYRQGYA TQTVGPWHLG KLEIDFGECP GTTVTIQEDC DHRGPSLRTT 

      1090       1100       1110       1120       1130       1140 
TASGKLVTQW CCRSCTMPPL RFLGEDGCWY GMEIRPLSEK EENMVKSQVT AGQGTSETFS 

      1150       1160       1170       1180       1190       1200 
MGLLCLTLFV EECLRRRVTR KHMILVVVIT LCAIILGGLT WMDLLRALIM LGDTMSGRIG 

      1210       1220       1230       1240       1250       1260 
GQIHLAIMAV FKMSPGYVLG VFLRKLTSRE TALMVIGMAM TTVLSIPHDL MELIDGISLG 

      1270       1280       1290       1300       1310       1320 
LILLKIVTQF DNTQVGTLAL SLTFIRSTMP LVMAWRTIMA VLFVVTLIPL CRTSCLQKQS 

      1330       1340       1350       1360       1370       1380 
HWVEITALIL GAQALPVYLM TLMKGASRRS WPLNEGIMAV GLVSLLGSAL LKNDVPLAGP 

      1390       1400       1410       1420       1430       1440 
MVAGGLLLAA YVMSGSSADL SLEKAANVQW DEMADITGSS PIIEVKQDED GSFSIRDVEE 

      1450       1460       1470       1480       1490       1500 
TNMITLLVKL ALITVSGLYP LAIPVTMTLW YMWQVKTQRS GALWDVPSPA ATKKAALSEG 

      1510       1520       1530       1540       1550       1560 
VYRIMQRGLF GKTQVGVGIH MEGVFHTMWH VTRGSVICHE TGRLEPSWAD VRNDMISYGG 

      1570       1580       1590       1600       1610       1620 
GWRLGDKWDK EEDVQVLAIE PGKNPKHVQT KPGLFKTLTG EIGAVTLDFK PGTSGSPIIN 

      1630       1640       1650       1660       1670       1680 
RKGKVIGLYG NGVVTKSGDY VSAITQAERI GEPDYEVDED IFRKKRLTIM DLHPGAGKTK 

      1690       1700       1710       1720       1730       1740 
RILPSIVREA LKRRLRTLIL APTRVVAAEM EEALRGLPIR YQTPAVKSEH TGREIVDLMC 

      1750       1760       1770       1780       1790       1800 
HATFTTRLLS STRVPNYNLI VMDEAHFTDP SSVAARGYIS TRVEMGEAAA IFMTATPPGA 

      1810       1820       1830       1840       1850       1860 
TDPFPQSNSP IEDIEREIPE RSWNTGFDWI TDYQGKTVWF VPSIKAGNDI ANCLRKSGKK 

      1870       1880       1890       1900       1910       1920 
VIQLSRKTFD TEYPKTKLTD WDFVVTTDIS EMGANFRAGR VIDPRRCLKP VILPDGPERV 

      1930       1940       1950       1960       1970       1980 
ILAGPIPVTP ASAAQRRGRI GRNPAQEDDQ YVFSGDPLKN DEDHAHWTEA KMLLDNIYTP 

      1990       2000       2010       2020       2030       2040 
EGIIPTLFGP EREKTQAIDG EFRLRGEQRK TFVELMRRGD LPVWLSYKVA SAGISYKDRE 

      2050       2060       2070       2080       2090       2100 
WCFTGERNNQ ILEENMEVEI WTREGEKKKL RPRWLDARVY ADPMALKDFK EFASGRKSIT 

      2110       2120       2130       2140       2150       2160 
LDILTEIASL PTYLSSRAKL ALDNIVMLHT TERGGRAYQH ALNELPESLE TLMLVALLGA 

      2170       2180       2190       2200       2210       2220 
MTAGIFLFFM QGKGIGKLSM GLITIAVASG LLWVAEIQPQ WIAASIILEF FLMVLLIPEP 

      2230       2240       2250       2260       2270       2280 
EKQRTPQDNQ LIYVILTILT IIGLIAANEM GLIEKTKTDF GFYQVKTETT ILDVDLRPAS 

      2290       2300       2310       2320       2330       2340 
AWTLYAVATT ILTPMLRHTI ENTSANLSLA AIANQAAVLM GLGKGWPLHR MDLGVPLLAM 

      2350       2360       2370       2380       2390       2400 
GCYSQVNPTT LTASLVMLLV HYAIIGPGLQ AKATREAQKR TAAGIMKNPT VDGITVIDLE 

      2410       2420       2430       2440       2450       2460 
PISYDPKFEK QLGQVMLLVL CAGQLLLMRT TWAFCEVLTL ATGPILTLWE GNPGRFWNTT 

      2470       2480       2490       2500       2510       2520 
IAVSTANIFR GSYLAGAGLA FSLIKNAQTP RRGTGTTGET LGEKWKRQLN SLDRKEFEEY 

      2530       2540       2550       2560       2570       2580 
KRSGILEVDR TEAKSALKDG SKIKHAVSRG SSKIRWIVER GMVKPKGKVV DLGCGRGGWS 

      2590       2600       2610       2620       2630       2640 
YYMATLKNVT EVKGYTKGGP GHEEPIPMAT YGWNLVKLHS GVDVFYKPTE QVDTLLCDIG 

      2650       2660       2670       2680       2690       2700 
ESSSNPTIEE GRTLRVLKMV EPWLSSKPEF CIKVLNPYMP TVIEELEKLQ RKHGGNLVRC 

      2710       2720       2730       2740       2750       2760 
PLSRNSTHEM YWVSGASGNI VSSVNTTSKM LLNRFTTRHR KPTYEKDVDL GAGTRSVSTE 

      2770       2780       2790       2800       2810       2820 
TEKPDMTIIG RRLQRLQEEH KETWHYDQEN PYRTWAYHGS YEAPSTGSAS SMVNGVVKLL 

      2830       2840       2850       2860       2870       2880 
TKPWDVIPMV TQLAMTDTTP FGQQRVFKEK VDTRTPQPKP GTRMVMTTTA NWLWALLGKK 

      2890       2900       2910       2920       2930       2940 
KNPRLCTREE FISKVRSNAA IGAVFQEEQG WTSASEAVND SRFWELVDKE RALHQEGKCE 

      2950       2960       2970       2980       2990       3000 
SCVYNMMGKR EKKLGEFGRA KGSRAIWYMW LGARFLEFEA LGFLNEDHWF GRENSWSGVE 

      3010       3020       3030       3040       3050       3060 
GEGLHRLGYI LEEIDKKDGD LMYADDTAGW DTRITEDDLQ NEELITEQMA PHHKILAKAI 

      3070       3080       3090       3100       3110       3120 
FKLTYQNKVV KVLRPTPRGA VMDIISRKDQ RGSGQVGTYG LNTFTNMEVQ LIRQMEAEGV 

      3130       3140       3150       3160       3170       3180 
ITQDDMQNPK GLKERVEKWL KECGVDRLKR MAISGDDCVV KPLDERFGTS LLFLNDMGKV 

      3190       3200       3210       3220       3230       3240 
RKDIPQWEPS KGWKNWQEVP FCSHHFHKIF MKDGRSLVVP CRNQDELIGR ARISQGAGWS 

      3250       3260       3270       3280       3290       3300 
LRETACLGKA YAQMWSLMYF HRRDLRLASM AICSAVPTEW FPTSRTTWSI HAHHQWMTTE 

      3310       3320       3330       3340       3350       3360 
DMLKVWNRVW IEDNPNMTDK TPVHSWEDIP YLGKREDLWC GSLIGLSSRA TWAKNIHTAI 

      3370       3380       3390 
TQVRNLIGKE EYVDYMPVMK RYSAPSESEG VL 

« Hide

References

[1]"Construction and characterization of chimeric tick-borne encephalitis/dengue type 4 viruses."
Pletnev A.G., Bray M., Huggins J., Lai C.J.
Proc. Natl. Acad. Sci. U.S.A. 89:10532-10536(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Structure of dengue virus: implications for flavivirus organization, maturation, and fusion."
Kuhn R.J., Zhang W., Rossmann M.G., Pletnev S.V., Corver J., Lenches E., Jones C.T., Mukhopadhyay S., Chipman P.R., Strauss E.G., Baker T.S., Strauss J.H.
Cell 108:717-725(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY ELECTRON MICROSCOPY (24.00 ANGSTROMS) OF 284-678.
[3]Pletnev A.G.
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FJ828987 Other RNA. Translation: ACO82049.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1K4Relectron microscopy24.00A/B/C284-678[»]
ProteinModelPortalC3V005.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS07.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.40.350. 1 hit.
2.60.98.10. 1 hit.
3.30.387.10. 1 hit.
3.30.67.10. 1 hit.
3.40.50.150. 1 hit.
3.40.50.300. 2 hits.
InterProIPR011492. DEAD_Flavivir.
IPR000069. Env_glycoprot_M_flavivir.
IPR013755. Flav_gly_cen_dom_subdom1.
IPR001122. Flavi_capsidC.
IPR026470. Flavi_E_Stem/Anchor_dom.
IPR001157. Flavi_NS1.
IPR000752. Flavi_NS2A.
IPR000487. Flavi_NS2B.
IPR000404. Flavi_NS4A.
IPR001528. Flavi_NS4B.
IPR002535. Flavi_propep.
IPR000336. Flavivir/Alphavir_Ig-like.
IPR001850. Flavivirus_NS3_S7.
IPR027287. Flavovir_Ig-like.
IPR014412. Gen_Poly_FLV.
IPR011998. Glycoprot_cen/dimer.
IPR013756. GlyE_cen_dom_subdom2.
IPR013754. GlyE_dim.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014756. Ig_E-set.
IPR026490. mRNA_cap_0/1_MeTrfase.
IPR027417. P-loop_NTPase.
IPR000208. RNA-dir_pol_flavivirus.
IPR007094. RNA-dir_pol_PSvirus.
IPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR029063. SAM-dependent_MTases-like.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF01003. Flavi_capsid. 1 hit.
PF07652. Flavi_DEAD. 1 hit.
PF02832. Flavi_glycop_C. 1 hit.
PF00869. Flavi_glycoprot. 1 hit.
PF01004. Flavi_M. 1 hit.
PF00948. Flavi_NS1. 1 hit.
PF01005. Flavi_NS2A. 1 hit.
PF01002. Flavi_NS2B. 1 hit.
PF01350. Flavi_NS4A. 1 hit.
PF01349. Flavi_NS4B. 1 hit.
PF00972. Flavi_NS5. 1 hit.
PF01570. Flavi_propep. 1 hit.
PF01728. FtsJ. 1 hit.
PF00949. Peptidase_S7. 1 hit.
[Graphical view]
PIRSFPIRSF003817. Gen_Poly_FLV. 1 hit.
SMARTSM00487. DEXDc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF53335. SSF53335. 1 hit.
SSF56983. SSF56983. 1 hit.
SSF81296. SSF81296. 1 hit.
TIGRFAMsTIGR04240. flavi_E_stem. 1 hit.
PROSITEPS51527. FLAVIVIRUS_NS2B. 1 hit.
PS51528. FLAVIVIRUS_NS3PRO. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
PS51591. RNA_CAP01_NS5_MT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceC3V005.

Entry information

Entry nameC3V005_9FLAV
AccessionPrimary (citable) accession number: C3V005
Entry history
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: July 9, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)