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Protein

Ribonucleoside-diphosphate reductase subunit beta

Gene

nrdF

Organism
Escherichia coli
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.UniRule annotation

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.UniRule annotation

Cofactori

Fe cationUniRule annotationNote: Binds 2 iron ions per subunit.UniRule annotation

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi67Iron 1UniRule annotation1
Metal bindingi98Iron 1UniRule annotation1
Metal bindingi98Iron 2UniRule annotation1
Metal bindingi101Iron 1UniRule annotation1
Active sitei105UniRule annotation1
Metal bindingi158Iron 2UniRule annotation1
Metal bindingi192Iron 2UniRule annotation1
Metal bindingi195Iron 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processDNA replicationUniRule annotation
LigandIronUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase subunit betaUniRule annotation (EC:1.17.4.1UniRule annotation)
Gene namesi
Name:nrdFImported
ORF Names:A5958_16655Imported, A9R57_07495Imported, AA102_05175Imported, AC789_1c29940Imported, ACN77_20625Imported, ACU57_06795Imported, ACU90_16330Imported, AM266_20415Imported, AM270_01450Imported, AMK83_10060Imported, AUQ13_17010Imported, B1K96_24840Imported, BHS87_15200Imported, BJJ90_05795Imported, BMT91_21360Imported, BUE81_12050Imported, BW690_13025Imported, EC3234A_47c00420Imported, ECs3539Imported, EL75_1008Imported, EL79_1019Imported, EL80_1021Imported, ERS085365_04324Imported, ERS085374_03220Imported, ERS085379_00730Imported, ERS085383_02319Imported, ERS085404_02111Imported, ERS085416_02073Imported, ERS139211_03273Imported, ERS139235_00373Imported, ERS150873_03341Imported, GJ11_17450Imported, GJ12_17435Imported, JD73_16880Imported, PGD_04427Imported, PU06_25625Imported, SK85_02911Imported, UN86_27120Imported, WR15_13150Imported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000044893 Componenti: Unassembled WGS sequence
  • UP000193530 Componenti: Unassembled WGS sequence
  • UP000044381 Componenti: Unassembled WGS sequence
  • UP000030018 Componenti: Unassembled WGS sequence
  • UP000030000 Componenti: Unassembled WGS sequence
  • UP000038112 Componenti: Unassembled WGS sequence
  • UP000188724 Componenti: Unassembled WGS sequence
  • UP000040589 Componenti: Unassembled WGS sequence
  • UP000092652 Componenti: Chromosome
  • UP000070045 Componenti: Unassembled WGS sequence
  • UP000033592 Componenti: Unassembled WGS sequence
  • UP000050307 Componenti: Unassembled WGS sequence
  • UP000037564 Componenti: Unassembled WGS sequence
  • UP000051846 Componenti: Unassembled WGS sequence
  • UP000194285 Componenti: Unassembled WGS sequence
  • UP000042305 Componenti: Unassembled WGS sequence
  • UP000040934 Componenti: Unassembled WGS sequence
  • UP000185422 Componenti: Chromosome
  • UP000034530 Componenti: Chromosome
  • UP000036012 Componenti: Unassembled WGS sequence
  • UP000043139 Componenti: Unassembled WGS sequence
  • UP000051850 Componenti: Unassembled WGS sequence
  • UP000028651 Componenti: Unassembled WGS sequence
  • UP000092566 Componenti: Chromosome
  • UP000186204 Componenti: Unassembled WGS sequence
  • UP000186169 Componenti: Unassembled WGS sequence
  • UP000188855 Componenti: Unassembled WGS sequence
  • UP000050556 Componenti: Unassembled WGS sequence
  • UP000031522 Componenti: Chromosome
  • UP000077539 Componenti: Unassembled WGS sequence
  • UP000076304 Componenti: Unassembled WGS sequence
  • UP000029988 Componenti: Unassembled WGS sequence
  • UP000095183 Componenti: Unassembled WGS sequence
  • UP000044658 Componenti: Unassembled WGS sequence
  • UP000077380 Componenti: Unassembled WGS sequence
  • UP000041959 Componenti: Unassembled WGS sequence
  • UP000030834 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Family & Domainsi

Sequence similaritiesi

Belongs to the ribonucleoside diphosphate reductase small chain family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R25. Bacteria.
COG0208. LUCA.

Family and domain databases

CDDicd01049. RNRR2. 1 hit.
InterProiView protein in InterPro
IPR009078. Ferritin-like_SF.
IPR026494. RNR_NrdF.
IPR033909. RNR_small.
IPR030475. RNR_small_AS.
IPR000358. RNR_small_fam.
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiView protein in Pfam
PF00268. Ribonuc_red_sm. 1 hit.
PIRSFiPIRSF000355. NrdB. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.
TIGRFAMsiTIGR04171. RNR_1b_NrdF. 1 hit.
PROSITEiView protein in PROSITE
PS00368. RIBORED_SMALL. 1 hit.

Sequencei

Sequence statusi: Complete.

C3SY95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLSRISAIN WNKISDDKDL EVWNRLTSNF WLPEKVPLSN DIPAWQTLTV
60 70 80 90 100
VEQQLTMRVF TGLTLLDTLQ NVIGAPSLMP DALTPHEEAV LSNISFMEAV
110 120 130 140 150
HARSYSSIFS TLCQTKDVDA AYAWSEENAP LQRKAQIIQQ HYRGDDPLKK
160 170 180 190 200
KIASVFLESF LFYSGFWLPM YFSSRGKLTN TADLIRLIIR DEAVHGYYIG
210 220 230 240 250
YKYQKNMEKI SLGQREELKS FAFDLLLELY DNELQYTDEL YAETPWADDV
260 270 280 290 300
KAFLCYNANK ALMNLGYEPL FPAEMAEVNP AILAALSPNA DENHDFFSGS
310
GSSYVMGKAV ETEDEDWNF
Length:319
Mass (Da):36,443
Last modified:June 16, 2009 - v1
Checksum:i0C95394CF150EEFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU896878 Genomic DNA. Translation: ACI79434.1.
CP010315 Genomic DNA. Translation: AJE57213.1.
CP011416 Genomic DNA. Translation: AKH23346.1.
CP015229 Genomic DNA. Translation: ANO90476.1.
CP015228 Genomic DNA. Translation: ANP19471.1.
CP017631 Genomic DNA. Translation: APT01570.1.
HG976963 Genomic DNA. Translation: CDU41420.1.
CXZU01000020 Genomic DNA. Translation: CTS01449.1.
CYBF01000004 Genomic DNA. Translation: CTT35178.1.
CYAQ01000054 Genomic DNA. Translation: CTT47352.1.
CYBJ01000010 Genomic DNA. Translation: CTT79278.1.
CYCH01000009 Genomic DNA. Translation: CTV03257.1.
CYCX01000014 Genomic DNA. Translation: CTV83736.1.
CYDH01000035 Genomic DNA. Translation: CTW45450.1.
CYEC01000001 Genomic DNA. Translation: CTW96780.1.
CYFX01000024 Genomic DNA. Translation: CTZ62911.1.
JPQG01000003 Genomic DNA. Translation: KFD75354.1.
JPKH01000009 Genomic DNA. Translation: KGM70867.1.
JPKL01000018 Genomic DNA. Translation: KGM83043.1.
JPMZ01000007 Genomic DNA. Translation: KGM84436.1.
JUDN01000162 Genomic DNA. Translation: KHJ13331.1.
JZDU01000160 Genomic DNA. Translation: KJW23442.1.
LEUM01000017 Genomic DNA. Translation: KLX95951.1.
LGZN01000028 Genomic DNA. Translation: KNF68895.1.
LDYI01000052 Genomic DNA. Translation: KPO15561.1.
LECN01000111 Genomic DNA. Translation: KPO51560.1.
LIVE01000043 Genomic DNA. Translation: KQJ12899.1.
LIVI01000001 Genomic DNA. Translation: KQJ46293.1.
LOOZ01000024 Genomic DNA. Translation: KXR88939.1.
LOCS01000119 Genomic DNA. Translation: KYV71208.1.
LCVH01000047 Genomic DNA. Translation: OAC43355.1.
LXPG01000002 Genomic DNA. Translation: OAJ88201.1.
LZEH01000101 Genomic DNA. Translation: OEI65788.1.
LGMU01000127 Genomic DNA. Translation: OKU09253.1.
MSEK01000078 Genomic DNA. Translation: OLR87223.1.
MTKH01000098 Genomic DNA. Translation: ONG28591.1.
MPAF01000052 Genomic DNA. Translation: OOK25031.1.
NAFT01000058 Genomic DNA. Translation: ORT01602.1.
NBCM01000044 Genomic DNA. Translation: OTE90327.1.
RefSeqiWP_000777969.1. NZ_NEFU01000013.1.

Genome annotation databases

EnsemblBacteriaiAJE57213; AJE57213; AC789_1c29940.
AKH23346; AKH23346; AA102_05175.
ALZ66102; ALZ66102; AWH59_08020.
ANO90476; ANO90476; GJ11_17450.
ANP19471; ANP19471; GJ12_17435.
AOT31663; AOT31663; FORC31_1198.
CDU41420; CDU41420; PGD_04427.
CTS01449; CTS01449; ERS085374_03220.
CTT35178; CTT35178; ERS085379_00730.
CTT47352; CTT47352; ERS085365_04324.
CTT79278; CTT79278; ERS085383_02319.
CTV03257; CTV03257; ERS085404_02111.
CTV83736; CTV83736; ERS085416_02073.
CTW45450; CTW45450; ERS139211_03273.
CTW96780; CTW96780; ERS139235_00373.
CTY03309; CTY03309; ERS139269_00717.
CTZ62911; CTZ62911; ERS150873_03341.
KFD75354; KFD75354; JD73_16880.
KGM70867; KGM70867; EL75_1008.
KGM83043; KGM83043; EL80_1021.
KGM84436; KGM84436; EL79_1019.
KHH07406; KHH07406; PU69_18485.
KHJ13331; KHJ13331; PU06_25625.
KIG81606; KIG81606; PU38_09475.
KIH36091; KIH36091; PD07_10940.
KJW23442; KJW23442; UN86_27120.
KLG77765; KLG77765; WR12_09180.
KLX95951; KLX95951; SK85_02911.
KNF68895; KNF68895; WR15_13150.
KPO15561; KPO15561; ACU57_06795.
KPO51560; KPO51560; ACU90_16330.
KQJ12899; KQJ12899; AM266_20415.
KQJ46293; KQJ46293; AM270_01450.
KXQ40647; KXQ40647; AUQ01_07660.
KYV71208; KYV71208; AMK83_10060.
OAC43355; OAC43355; EC3234A_47c00420.
OAJ88201; OAJ88201; A5958_16655.
OCO60785; OCO60785; AN669_0208545.
ODA88002; ODA88002; A9D65_16765.
ODH32250; ODH32250; A6803_05175.
OEI65788; OEI65788; A9R57_07495.
PATRICifig|562.10471.peg.3006.

Similar proteinsi

Entry informationi

Entry nameiC3SY95_ECOLX
AccessioniPrimary (citable) accession number: C3SY95
Entry historyiIntegrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: September 27, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported