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Protein

Aspartate--ammonia ligase

Gene

asnA

Organism
Escherichia coli
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine.UniRule annotationSAAS annotation

Pathwayi: L-asparagine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-asparagine from L-aspartate (ammonia route).UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA), Aspartate--ammonia ligase (asnA)
This subpathway is part of the pathway L-asparagine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-asparagine from L-aspartate (ammonia route), the pathway L-asparagine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Asparagine biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00134; UER00194.

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate--ammonia ligaseUniRule annotationSAAS annotation (EC:6.3.1.1UniRule annotationSAAS annotation)
Alternative name(s):
Asparagine synthetase AUniRule annotation
Gene namesi
Name:asnAUniRule annotationImported
ORF Names:A4T40_24415Imported, AML35_23895Imported, APU18_07725Imported, ARC77_15660Imported, AU473_02200Imported, AW110_21400Imported, BHF46_03190Imported, BK248_08205Imported, BK334_16030Imported, BK400_00950Imported, BMT94_11570Imported, BWP17_24885Imported, BXT93_11540Imported, CA268_02905Imported, ECONIH1_22050Imported, ECs4686Imported, ERS085366_03542Imported, ERS085383_02621Imported, ERS085386_04250Imported, ERS085404_04413Imported, MS6198_43120Imported, SM09_04731Imported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000184168 Componenti: Unassembled WGS sequence
  • UP000043139 Componenti: Unassembled WGS sequence
  • UP000076106 Componenti: Unassembled WGS sequence
  • UP000042887 Componenti: Unassembled WGS sequence
  • UP000192295 Componenti: Unassembled WGS sequence
  • UP000188758 Componenti: Unassembled WGS sequence
  • UP000076266 Componenti: Chromosome
  • UP000030317 Componenti: Chromosome
  • UP000036405 Componenti: Unassembled WGS sequence
  • UP000053450 Componenti: Unassembled WGS sequence
  • UP000044658 Componenti: Unassembled WGS sequence
  • UP000188967 Componenti: Unassembled WGS sequence
  • UP000188999 Componenti: Unassembled WGS sequence
  • UP000184459 Componenti: Unassembled WGS sequence
  • UP000177471 Componenti: Chromosome
  • UP000094504 Componenti: Chromosome
  • UP000194331 Componenti: Chromosome
  • UP000194184 Componenti: Unassembled WGS sequence
  • UP000184336 Componenti: Unassembled WGS sequence
  • UP000095493 Componenti: Unassembled WGS sequence
  • UP000045242 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 327AA_TRNA_LIGASE_IIInterPro annotationAdd BLAST315

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CU9. Bacteria.
COG2502. LUCA.

Family and domain databases

CDDicd00645. AsnA. 1 hit.
HAMAPiMF_00555. AsnA. 1 hit.
InterProiView protein in InterPro
IPR006195. aa-tRNA-synth_II.
IPR004618. AsnA.
PfamiView protein in Pfam
PF03590. AsnA. 1 hit.
PIRSFiPIRSF001555. Asp_ammon_ligase. 1 hit.
TIGRFAMsiTIGR00669. asnA. 1 hit.
PROSITEiView protein in PROSITE
PS50862. AA_TRNA_LIGASE_II. 1 hit.

Sequencei

Sequence statusi: Complete.

C3SL47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTAYIAKQR QISFVKSHFS RQLEERLGLI EVQAPILSRV GDGTQDNLSG
60 70 80 90 100
CEKAVQVKVK ALPDAQFEVV HSLAKWKRQT LGQHDFSAGE GLYTHMKALR
110 120 130 140 150
PDEDRLSPLH SVYVDQWDWE RVMGDGERQF STLKSTVEAI WAGIKATEAA
160 170 180 190 200
VSEEFGLAPF LPDQIHFVHS QELLSRYPDL DAKGRERAIA KDLGAVFLVG
210 220 230 240 250
IGGKLSDGHR HDVRAPDYDD WSTPSELGHA GLNGDILVWN PVLEDAFELS
260 270 280 290 300
SMGIRVDADT LKHQLALTGD EDRLQLEWHQ ALLRGEMPQT IGGGIGQSRL
310 320 330
TMLLLQLPHI GQVQCGVWPA AVRESVPSLL
Length:330
Mass (Da):36,650
Last modified:June 16, 2009 - v1
Checksum:i6E8D3A2ACE523FC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU892625 Genomic DNA. Translation: ACI75191.1.
EU892626 Genomic DNA. Translation: ACI75192.1.
EU892627 Genomic DNA. Translation: ACI75193.1.
EU892628 Genomic DNA. Translation: ACI75194.1.
EU892629 Genomic DNA. Translation: ACI75195.1.
CP009859 Genomic DNA. Translation: AIX65741.1.
CP015020 Genomic DNA. Translation: AMW43586.1.
CP015834 Genomic DNA. Translation: AOM72280.1.
CP017669 Genomic DNA. Translation: APA39770.1.
CP021202 Genomic DNA. Translation: ARR58474.1.
CYAV01000047 Genomic DNA. Translation: CTT44247.1.
CYBJ01000012 Genomic DNA. Translation: CTT82645.1.
CYBM01000030 Genomic DNA. Translation: CTU12341.1.
CYCH01000043 Genomic DNA. Translation: CTV85985.1.
LEYN01000040 Genomic DNA. Translation: KME62104.1.
LNIP01000006 Genomic DNA. Translation: KSZ22058.1.
LOGT01000159 Genomic DNA. Translation: KYS88437.1.
MIWY01000003 Genomic DNA. Translation: OEN37250.1.
MOFD01000018 Genomic DNA. Translation: OJK75806.1.
MOIL01000016 Genomic DNA. Translation: OJP12618.1.
MOKZ01000002 Genomic DNA. Translation: OJS91246.1.
MTPS01000172 Genomic DNA. Translation: ONG34803.1.
MTFS01000062 Genomic DNA. Translation: OOC76020.1.
MOZG01000013 Genomic DNA. Translation: OOJ07276.1.
NCRV01000003 Genomic DNA. Translation: ORD24380.1.
NEOD01000061 Genomic DNA. Translation: OTE05347.1.
RefSeqiWP_000845107.1. NZ_NEFT01000070.1.

Genome annotation databases

EnsemblBacteriaiAIX65741; AIX65741; ECONIH1_22050.
AMW43586; AMW43586; ARC77_15660.
AOM72280; AOM72280; MS6198_43120.
CTT44247; CTT44247; ERS085366_03542.
CTT82645; CTT82645; ERS085383_02621.
CTU12341; CTU12341; ERS085386_04250.
CTV85985; CTV85985; ERS085404_04413.
KHI30630; KHI30630; PU33_15550.
KLX90929; KLX90929; SK83_01221.
KME62104; KME62104; SM09_04731.
KSZ22058; KSZ22058; APU18_07725.
KUU44873; KUU44873; AWF22_04030.
KXG96933; KXG96933; HMPREF3041_01749.
KYS88437; KYS88437; AML35_23895.
OAF41633; OAF41633; AXK33_12910.
OAO72389; OAO72389; OK10_18810.
ODH22669; ODH22669; A6804_13065.
OEG66311; OEG66311; A7H95_13105.
OEN37250; OEN37250; BHF46_03190.
PATRICifig|562.10852.peg.1728.

Similar proteinsi

Entry informationi

Entry nameiC3SL47_ECOLX
AccessioniPrimary (citable) accession number: C3SL47
Secondary accession number(s): A0A0J3V972
Entry historyiIntegrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: August 30, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported