C3RAU9 (C3RAU9_9BACE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Dihydroorotate dehydrogenase HAMAP MF_00224
Short name=DHOD HAMAP MF_00224
Short name=DHODase HAMAP MF_00224
Short name=DHOdehase HAMAP MF_00224
EC=1.3.-.- HAMAP MF_00224

Gene names

Name:	pyrD HAMAP MF_00224
ORF Names:	BSEG_02315 EMBL EEO46174.1

Organism

Bacteroides dorei 5_1_36/D4 EMBL EEO46174.1

Taxonomic identifier

556260 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of dihydroorotate to orotate By similarity. HAMAP MF_00224
Catalytic activity	(S)-dihydroorotate + acceptor = orotate + reduced acceptor. HAMAP MF_00224
Cofactor	Binds 1 FMN per subunit By similarity. SAAS SAAS012135 HAMAP MF_00224
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway. HAMAP MF_00224
Subcellular location	Cytoplasm By similarity HAMAP MF_00224.
Sequence similarities	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. HAMAP MF_00224
Caution	The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis SAAS SAAS012135 HAMAP MF_00224
Cellular component	Cytoplasm HAMAP MF_00224
Ligand	FMN SAAS SAAS012135 HAMAP MF_00224 Flavoprotein SAAS SAAS012135 HAMAP MF_00224
Molecular function	Oxidoreductase SAAS SAAS012135 HAMAP MF_00224
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro UMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	dihydroorotate oxidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	130	1	Nucleophile By similarity PIRSR PIRSR000164-1

Sequences

	Sequence		Length	Mass (Da)
	C3RAU9 [UniParc]. Last modified June 16, 2009. Version 1. Checksum: 7731AA817CD6A67F	FASTA	303	32,303
	10 20 30 40 50 60 MADLSVNIGD LKLCNPVMTA SGTFGYGKEF EDFVDLEKIG GIIVKGTTLH HREGNPYPRM 70 80 90 100 110 120 AETPMGMLNA VGLQNKGVDY FVEHIYPQIR DIHTNMIVNV SGSAVEDYVK TAEIINDLDH 130 140 150 160 170 180 IPAIELNISC PNVKQGGMAF GVSACGCSEV VKAVRNVYKK TLIVKLSPNV TDITEIARAA 190 200 210 220 230 240 EASGADSVSL INTLLGMAVD AEKRRPVLST ITGGMSGAAV KPIALRMVWQ VAKAVNIPVI 250 260 270 280 290 300 GLGGIMGWKD AVEFMLAGAT AIQIGTANFI DPAITVKVSE GINDYLERHG YTSVKDIIGA LEV

References

[1]

"The Genome Sequence of Bacteroides dorei 5_1_36/D4." The Broad Institute Genome Sequencing Platform Earl A., Ward D., Feldgarden M., Gevers D., Strauss J., Sibley C., White A., Allen-Vercoe E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Brown A. , Chapman S.B., Chen Z., Dunbar C., Freedman E., Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Mehta T., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B. Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: 5_1_36/D4 EMBL EEO46174.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	ACDI02000026 Genomic DNA. Translation: EEO46174.1.
3D structure databases
ProteinModelPortal	C3RAU9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
PATRIC	30569380. VBIBacSp91558_2419.
Family and domain databases
HAMAP	MF_00224. DHO_dh_type1. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR005720. Dihydroorotate_DH. IPR024920. Dihydroorotate_DH_1. IPR012135. Dihydroorotate_DH_1_2. IPR001295. Dihydroorotate_DH_CS. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF01180. DHO_dh. 1 hit. [Graphical view]
PIRSF	PIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMs	TIGR01037. PyrD_sub1_fam. 1 hit.
PROSITE	PS00911. DHODEHASE_1. 1 hit. PS00912. DHODEHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C3RAU9_9BACE

Accession

Primary (citable) accession number: C3RAU9

Entry history

Integrated into UniProtKB/TrEMBL:	June 16, 2009
Last sequence update:	June 16, 2009
Last modified:	January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)