ID PAUF_HUMAN Reviewed; 172 AA. AC Q96DA0; A6NIY1; B2R4F6; C3PTT6; Q6UW28; DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot. DT 24-JAN-2024, sequence version 4. DT 27-MAR-2024, entry version 146. DE RecName: Full=Pancreatic adenocarcinoma up-regulated factor {ECO:0000303|PubMed:19302292}; DE AltName: Full=Zymogen granule protein 16 homolog B; DE Flags: Precursor; GN Name=ZG16B; Synonyms=PAUF {ECO:0000303|PubMed:19302292}; GN ORFNames=UNQ773/PRO1567; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 17-22, FUNCTION, RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND GLYCOSYLATION. RC TISSUE=Placenta; RX PubMed=19302292; DOI=10.1111/j.1349-7006.2009.01106.x; RA Kim S.A., Lee Y., Jung D.E., Park K.H., Park J.Y., Gang J., Jeon S.B., RA Park E.C., Kim Y.G., Lee B., Liu Q., Zeng W., Yeramilli S., Lee S., RA Koh S.S., Song S.Y.; RT "Pancreatic adenocarcinoma up-regulated factor (PAUF), a novel up-regulated RT secretory protein in pancreatic ductal adenocarcinoma."; RL Cancer Sci. 100:828-836(2009). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale effort to RT identify novel human secreted and transmembrane proteins: a bioinformatics RT assessment."; RL Genome Res. 13:2265-2270(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15616553; DOI=10.1038/nature03187; RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M., RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., RA Myers R.M., Rubin E.M., Pennacchio L.A.; RT "The sequence and analysis of duplication-rich human chromosome 16."; RL Nature 432:988-994(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Lung carcinoma; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Trachea; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [7] RP IDENTIFICATION BY MASS SPECTROMETRY. RX PubMed=11678034; RX DOI=10.1002/1615-9861(200104)1:5<641::aid-prot641>3.0.co;2-r; RA Kuster B., Mortensen P., Andersen J.S., Mann M.; RT "Mass spectrometry allows direct identification of proteins in large RT genomes."; RL Proteomics 1:641-650(2001). RN [8] RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH TLR4. RX PubMed=36232715; DOI=10.3390/ijms231911414; RA Youn S.E., Jiang F., Won H.Y., Hong D.E., Kang T.H., Park Y.Y., Koh S.S.; RT "PAUF Induces Migration of Human Pancreatic Cancer Cells Exclusively via RT the TLR4/MyD88/NF-kappaB Signaling Pathway."; RL Int. J. Mol. Sci. 23:0-0(2022). RN [9] RP X-RAY CRYSTALLOGRAPHY (2.75 ANGSTROMS) OF 17-172. RX PubMed=21110947; DOI=10.1016/j.bbrc.2010.11.093; RA Kanagawa M., Satoh T., Ikeda A., Nakano Y., Yagi H., Kato K., RA Kojima-Aikawa K., Yamaguchi Y.; RT "Crystal structures of human secretory proteins ZG16p and ZG16b reveal a RT Jacalin-related beta-prism fold."; RL Biochem. Biophys. Res. Commun. 404:201-205(2011). CC -!- FUNCTION: Plays an important role in pancreatic tumor progression and CC metastasis (PubMed:19302292, PubMed:36232715). Promotes pancreatic CC cancer cells migration and invasion through the TLR4/MyD88/NF-kaapaB CC signaling pathway, without the involvement of the TLR4/TRIF pathway CC (PubMed:36232715). {ECO:0000269|PubMed:19302292, CC ECO:0000269|PubMed:36232715}. CC -!- INTERACTION: CC Q96DA0; Q9BT25: HAUS8; NbExp=3; IntAct=EBI-953824, EBI-2558143; CC Q96DA0; Q9UJW9: SERTAD3; NbExp=5; IntAct=EBI-953824, EBI-748621; CC Q96DA0; O43765: SGTA; NbExp=3; IntAct=EBI-953824, EBI-347996; CC Q96DA0; Q96EQ0: SGTB; NbExp=5; IntAct=EBI-953824, EBI-744081; CC Q96DA0; Q9BSL1: UBAC1; NbExp=3; IntAct=EBI-953824, EBI-749370; CC Q96DA0; Q9UHD9: UBQLN2; NbExp=6; IntAct=EBI-953824, EBI-947187; CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19302292}. Cytoplasm CC {ECO:0000269|PubMed:19302292}. Cell membrane CC {ECO:0000269|PubMed:36232715}. Apicolateral cell membrane CC {ECO:0000269|PubMed:19302292}. Note=Co-localizes with TLR4 at the cell CC membrane of pancreatic cancer cells. {ECO:0000269|PubMed:36232715}. CC -!- TISSUE SPECIFICITY: Highly expressed in pancreatic cancer tissues (at CC protein levels). Also expressed in the placenta and colon and ovarian CC cancer tumors. {ECO:0000269|PubMed:19302292}. CC -!- PTM: N-glycosylated. {ECO:0000269|PubMed:19302292}. CC -!- SIMILARITY: Belongs to the jacalin lectin family. {ECO:0000255|PROSITE- CC ProRule:PRU01088, ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAH09722.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; CC Sequence=AAQ89380.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; CC Sequence=ABM92915.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; CC Sequence=EAW85462.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EF067313; ABM92915.1; ALT_INIT; mRNA. DR EMBL; AY359021; AAQ89380.1; ALT_INIT; mRNA. DR EMBL; AC005361; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471112; EAW85462.1; ALT_SEQ; Genomic_DNA. DR EMBL; BC009722; AAH09722.2; ALT_INIT; mRNA. DR EMBL; AK311810; BAG34753.1; -; mRNA. DR RefSeq; NP_660295.2; NM_145252.2. DR PDB; 3AQG; X-ray; 2.75 A; A/B=17-172. DR PDBsum; 3AQG; -. DR AlphaFoldDB; Q96DA0; -. DR SMR; Q96DA0; -. DR BioGRID; 125855; 199. DR IntAct; Q96DA0; 48. DR MINT; Q96DA0; -. DR STRING; 9606.ENSP00000371715; -. DR UniLectin; Q96DA0; -. DR GlyConnect; 1909; 6 N-Linked glycans (1 site). DR GlyCosmos; Q96DA0; 1 site, 6 glycans. DR GlyGen; Q96DA0; 1 site, 6 N-linked glycans (1 site). DR iPTMnet; Q96DA0; -. DR PhosphoSitePlus; Q96DA0; -. DR BioMuta; ZG16B; -. DR DMDM; 152031723; -. DR EPD; Q96DA0; -. DR jPOST; Q96DA0; -. DR MassIVE; Q96DA0; -. DR MaxQB; Q96DA0; -. DR PaxDb; 9606-ENSP00000371715; -. DR PeptideAtlas; Q96DA0; -. DR PRIDE; Q96DA0; -. DR ProteomicsDB; 76263; -. DR Pumba; Q96DA0; -. DR Antibodypedia; 23906; 138 antibodies from 17 providers. DR DNASU; 124220; -. DR Ensembl; ENST00000382280.8; ENSP00000371715.4; ENSG00000162078.12. DR Ensembl; ENST00000572863.2; ENSP00000461740.2; ENSG00000162078.12. DR Ensembl; ENST00000634500.1; ENSP00000489035.1; ENSG00000283056.1. DR GeneID; 124220; -. DR KEGG; hsa:124220; -. DR MANE-Select; ENST00000382280.8; ENSP00000371715.4; NM_145252.3; NP_660295.3. DR UCSC; uc002cru.4; human. DR AGR; HGNC:30456; -. DR CTD; 124220; -. DR DisGeNET; 124220; -. DR GeneCards; ZG16B; -. DR HGNC; HGNC:30456; ZG16B. DR HPA; ENSG00000162078; Tissue enriched (salivary). DR MIM; 620477; gene. DR neXtProt; NX_Q96DA0; -. DR OpenTargets; ENSG00000162078; -. DR PharmGKB; PA164727732; -. DR VEuPathDB; HostDB:ENSG00000162078; -. DR eggNOG; ENOG502SWMW; Eukaryota. DR GeneTree; ENSGT00940000163143; -. DR InParanoid; Q96DA0; -. DR OMA; STTCWAG; -. DR OrthoDB; 4640710at2759; -. DR PhylomeDB; Q96DA0; -. DR TreeFam; TF333440; -. DR PathwayCommons; Q96DA0; -. DR SignaLink; Q96DA0; -. DR BioGRID-ORCS; 124220; 10 hits in 1157 CRISPR screens. DR ChiTaRS; ZG16B; human. DR GeneWiki; LOC124220; -. DR GenomeRNAi; 124220; -. DR Pharos; Q96DA0; Tbio. DR PRO; PR:Q96DA0; -. DR Proteomes; UP000005640; Chromosome 16. DR RNAct; Q96DA0; Protein. DR Bgee; ENSG00000162078; Expressed in olfactory segment of nasal mucosa and 87 other cell types or tissues. DR ExpressionAtlas; Q96DA0; baseline and differential. DR GO; GO:0016327; C:apicolateral plasma membrane; IDA:UniProtKB. DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB. DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB. DR GO; GO:0005576; C:extracellular region; IDA:UniProtKB. DR GO; GO:0005615; C:extracellular space; HDA:UniProtKB. DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB. DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW. DR GO; GO:0016477; P:cell migration; IDA:UniProtKB. DR CDD; cd09611; Jacalin_ZG16_like; 1. DR Gene3D; 2.100.10.30; Jacalin-like lectin domain; 1. DR InterPro; IPR001229; Jacalin-like_lectin_dom. DR InterPro; IPR036404; Jacalin-like_lectin_dom_sf. DR PANTHER; PTHR33589; OS11G0524900 PROTEIN; 1. DR PANTHER; PTHR33589:SF1; ZYMOGEN GRANULE PROTEIN 16 HOMOLOG B; 1. DR Pfam; PF01419; Jacalin; 1. DR SMART; SM00915; Jacalin; 1. DR SUPFAM; SSF51101; Mannose-binding lectins; 1. DR PROSITE; PS51752; JACALIN_LECTIN; 1. DR Genevisible; Q96DA0; HS. PE 1: Evidence at protein level; KW 3D-structure; Cell membrane; Cytoplasm; Direct protein sequencing; KW Glycoprotein; Lectin; Membrane; Reference proteome; Secreted; Signal. FT SIGNAL 1..16 FT /evidence="ECO:0000255" FT CHAIN 17..172 FT /note="Pancreatic adenocarcinoma up-regulated factor" FT /id="PRO_0000248073" FT DOMAIN 17..149 FT /note="Jacalin-type lectin" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01088" FT CARBOHYD 161 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT VARIANT 97 FT /note="M -> V (in dbSNP:rs35533993)" FT /id="VAR_060067" FT STRAND 20..22 FT /evidence="ECO:0007829|PDB:3AQG" FT STRAND 25..29 FT /evidence="ECO:0007829|PDB:3AQG" FT STRAND 38..45 FT /evidence="ECO:0007829|PDB:3AQG" FT STRAND 47..61 FT /evidence="ECO:0007829|PDB:3AQG" FT STRAND 70..76 FT /evidence="ECO:0007829|PDB:3AQG" FT STRAND 83..101 FT /evidence="ECO:0007829|PDB:3AQG" FT STRAND 106..110 FT /evidence="ECO:0007829|PDB:3AQG" FT STRAND 114..119 FT /evidence="ECO:0007829|PDB:3AQG" FT STRAND 127..136 FT /evidence="ECO:0007829|PDB:3AQG" FT STRAND 139..148 FT /evidence="ECO:0007829|PDB:3AQG" SQ SEQUENCE 172 AA; 18879 MW; BC34ADFB33A99AEF CRC64; MLLLLTLALL GGPTWAGKMY GPGGGKYFST TEDYDHEITG LRVSVGLLLV KSVQVKLGDS WDVKLGALGG NTQEVTLQPG EYITKVFVAF QAFLRGMVMY TSKDRYFYFG KLDGQISSAY PSQEGQVLVG IYGQYQLLGI KSIGFEWNYP LEEPTTEPPV NLTYSANSPV GR //