Skip Header

Contribute Send feedback
Read comments (?) or add your own

C3PP36 (C3PP36_RICAE) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase RuleBase RU004136
EC=6.3.2.10 RuleBase RU004136
Gene names
Name:murF EMBL ACP53696.1
Ordered Locus Names:RAF_ORF0826 EMBL ACP53696.1
OrganismRickettsia africae (strain ESF-5) [Complete proteome] [HAMAP] EMBL ACP53696.1
Taxonomic identifier347255 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group ›

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein By similarity.

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the MurCDEF family. RuleBase RU003630

Sequences

Sequence LengthMass (Da)Tools
C3PP36 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: 3BDF2B5027F8ADC5

FASTA44950,345
        10         20         30         40         50         60 
MIWNSKTLSA VLGITISNSI SCNEVQFNSK DVKKGNLFIA LQGNRDGHDY VLDAIDKGAA 

        70         80         90        100        110        120 
AVIISKRVEI NDKDKIILVD DCFEALQKMA LYKRENSKAK FIAITGSVGK TSTKEALKVL 

       130        140        150        160        170        180 
LQHDFLVFAS RGNFNNKLGM LINLASMADD TEYAIFELGM NHKGEIRELV QILKPNIAMI 

       190        200        210        220        230        240 
TNISEAHLEF FNSLEEIAEA KCEIFANFSK NDIAVINADT NCYNKILSIL KKLSITDIHS 

       250        260        270        280        290        300 
FGRSAKTSAE LILYENLGEQ VYLKYKINKK VLDVMIPFIP RHFTENYTGV LLIIDILGKD 

       310        320        330        340        350        360 
IEIAANHLAN ISPTKGRGEI INIQNCRVIC DYYNASPQSM KAALEYLKQV PAENKTAIIG 

       370        380        390        400        410        420 
DMLELGENSK RLHEKLVQYI LDAACSKVYL VGVNTKYIND LLPSKIAKKY FKNVDELITH 

       430        440 
ITDLFEGNEL ILIKGSRGVK LDKIVDYYK

« Hide

References

[1]"Analysis of the Rickettsia africae genome reveals that virulence acquisition in Rickettsia species may be explained by genome reduction."
Fournier P.E., El Karkouri K., Leroy Q., Robert C., Giumelli B., Renesto P., Socolovschi C., Parola P., Audic S., Raoult D.
BMC Genomics 10:166-166(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ESF-5 EMBL ACP53696.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001612 Genomic DNA. Translation: ACP53696.1.
RefSeqYP_002845439.1. NC_012633.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING347255.RAF_ORF0826.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACP53696; ACP53696; RAF_ORF0826.
GeneID7815632.
KEGGraf:RAF_ORF0826.
PATRIC17873793. VBIRicAfr6986_1019.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0770.
HOGENOMHOG000268119.
KOK01929.
OMANHKGEIR.
ProtClustDBCLSK871006.

Enzyme and pathway databases

BioCycRAFR347255:GJCT-778-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.40.1190.10. 1 hit.
3.90.190.20. 1 hit.
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005863. UDP-N-AcMur-pentapeptide_synth.
[Graphical view]
PANTHERPTHR23135:SF3. PTHR23135:SF3. 1 hit.
PfamPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01143. murF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC3PP36_RICAE
AccessionPrimary (citable) accession number: C3PP36
Entry history
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: May 1, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info