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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Rickettsia africae (strain ESF-5)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei198ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotationSAAS annotationImported, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotationSAAS annotation (EC:6.1.1.2UniRule annotationSAAS annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Gene namesi
Name:trpSUniRule annotationImported
Ordered Locus Names:RAF_ORF0697Imported
OrganismiRickettsia africae (strain ESF-5)Imported
Taxonomic identifieri347255 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000002305 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC3PNS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi11 – 19"HIGH" regionUniRule annotation9
Motifi195 – 199"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000059940.
KOiK01867.
OMAiGWGQFKP.

Family and domain databases

CDDicd00806. TrpRS_core. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_B. Trp_tRNA_synth_B. 1 hit.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.

Sequencei

Sequence statusi: Complete.

C3PNS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKTVLSGVQ ATGSLHLGNY LGAIKNWVKM QEEYNCFFFL ADLHAITVDI
60 70 80 90 100
KPSELNNSIM EVLAVYLAAG LNPDKVTIFA QSMVKEHTEL AWLLNCVTPL
110 120 130 140 150
GWLKRMTQFK DKAGSDQEKA CLGLFSYPVL MAADILIYKA DIVPVGEDQK
160 170 180 190 200
QHLELTRDIA GVINRKFNKE ILKVPEVLIS ETGTRIMSLR DGLKKMSKSD
210 220 230 240 250
ISDFSRINLK DNNDLIHQKI KKAKTDHLSF VSYDQETRPE ISNLLDIYSS
260 270 280 290 300
LSEESLEKII GNYQNQGFAK FKEDLAEIII TNLQPIRNKY LELMNDKEYL
310 320 330
LKILHKGAEK ARIRASETVN EVKEQFGFVI
Length:330
Mass (Da):37,503
Last modified:June 16, 2009 - v1
Checksum:i964BF64DDE81E6AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001612 Genomic DNA. Translation: ACP53587.1.
RefSeqiWP_012719785.1. NC_012633.1.

Genome annotation databases

EnsemblBacteriaiACP53587; ACP53587; RAF_ORF0697.
KEGGiraf:RAF_ORF0697.
PATRICi17873433. VBIRicAfr6986_0845.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001612 Genomic DNA. Translation: ACP53587.1.
RefSeqiWP_012719785.1. NC_012633.1.

3D structure databases

ProteinModelPortaliC3PNS7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACP53587; ACP53587; RAF_ORF0697.
KEGGiraf:RAF_ORF0697.
PATRICi17873433. VBIRicAfr6986_0845.

Phylogenomic databases

HOGENOMiHOG000059940.
KOiK01867.
OMAiGWGQFKP.

Family and domain databases

CDDicd00806. TrpRS_core. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_B. Trp_tRNA_synth_B. 1 hit.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiC3PNS7_RICAE
AccessioniPrimary (citable) accession number: C3PNS7
Entry historyi
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: November 30, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.