C3PNH0 (PPNK_RICAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase
Short name=Poly(P)/ATP NAD kinase
EC=2.7.1.23

Gene names

Name:	ppnK
Ordered Locus Names:	RAF_ORF0571

Organism

Rickettsia africae (strain ESF-5) [Complete proteome] [HAMAP]

Taxonomic identifier

347255 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia africae

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP-Rule MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361
Cofactor	Divalent metal ions By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	NAD metabolic process Inferred from electronic annotation. Source: InterPro NADP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Probable inorganic polyphosphate/ATP-NAD kinase HAMAP-Rule MF_00361		PRO_1000205423

Sequences

	Sequence		Length	Mass (Da)
	C3PNH0 [UniParc]. Last modified June 16, 2009. Version 1. Checksum: 0628C04D2B62B198	FASTA	255	28,517
	10 20 30 40 50 60 MNINKIALIY NHNSKHLAII EEIKQLYNYC KIEEAEVIIV IGGDGELLHN IHRYMHLNIP 70 80 90 100 110 120 FYGVNLGSLG FLMNPLDTKK LLQNIHESTV SILNPLLMQV EDTSGQIYTA LAINEVSIFR 130 140 150 160 170 180 KTNQAAKFRI EVNGIERMSE LVADGALVAT PAGSSAYNLS ASGPILPLES NMLCLTPICS 190 200 210 220 230 240 FRPRRWHGAL LLSSATIKFE ILNTNKRPVN ATADFQEFNN ITNVTVKSTK DKPVKLLFNK 250 NHTLEDRIIK EQFGG

References

[1]

"Analysis of the Rickettsia africae genome reveals that virulence acquisition in Rickettsia species may be explained by genome reduction." Fournier P.-E., El Karkouri K., Leroy Q., Robert C., Giumelli B., Renesto P., Socolovschi C., Parola P., Audic S., Raoult D. BMC Genomics 10:166-166(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ESF-5.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001612 Genomic DNA. Translation: ACP53480.1.
RefSeq	YP_002845223.1. NC_012633.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	347255.RAF_ORF0571.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACP53480; ACP53480; RAF_ORF0571.
GeneID	7814987.
KEGG	raf:RAF_ORF0571.
PATRIC	17873104. VBIRicAfr6986_0687.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0061.
HOGENOM	HOG000139847.
KO	K00858.
OMA	QNIHEST.
ProtClustDB	PRK04761.
Enzyme and pathway databases
BioCyc	RAFR347255:GJCT-535-MONOMER.
Family and domain databases
Gene3D	2.60.200.30. 1 hit. 3.40.50.10330. 1 hit.
HAMAP	MF_00361. NAD_kinase.
InterPro	IPR017438. ATP-NAD_kinase_dom_1. IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. PolyP/ATP_NADK_prd. [Graphical view]
PANTHER	PTHR20275. PTHR20275. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPNK_RICAE

Accession

Primary (citable) accession number: C3PNH0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	June 16, 2009
Last modified:	May 1, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program