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C3PNE7

- SYL_RICAE

UniProt

C3PNE7 - SYL_RICAE

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rickettsia africae (strain ESF-5)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei605 – 6051ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRAFR347255:GJCT-511-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:RAF_ORF0546
    OrganismiRickettsia africae (strain ESF-5)
    Taxonomic identifieri347255 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000002305: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 835835Leucine--tRNA ligasePRO_1000202227Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi347255.RAF_ORF0546.

    Structurei

    3D structure databases

    ProteinModelPortaliC3PNE7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi36 – 4611"HIGH" regionAdd
    BLAST
    Motifi602 – 6065"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C3PNE7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNQIEQKWQY IWQEEKAFEV SNASSKPKYY VLEMLPYPSG KIHVGHVRNY    50
    SIGDVIARFM TMQGFNVLHP MGWDAFGLPA EHAAIKNNSH PKKWTYSNIK 100
    NMKKQLKSMG FSYDWSREIN SCDPEYYKHE QKFFLELYER NLAYQKESFV 150
    NWDPVDNTVL ANEQVVDGRG WRSGAIVVKR YLKQWFLKIT DYAEELLNEI 200
    QNLKEWPEAV RSMQEKWIGK SIGANFHFKI KDNEETTIEV FSTKPETIFG 250
    ASFIGIAFNH PIIERLVSKT PEILAFITQC SHITRSSELE KTEREGVFTG 300
    LFVIHPFDSN IVLPVIITNF VLMDYGTGAI FGCPAHDECD HELAVKMNLS 350
    IKQVIKADMD VQKTAYTEDG ILINSDFLNG LTSHEAKQEV IGEFEKLGIG 400
    KRSVNYRLKD WGISRQRFWG CPIPMIHCEI CGIVPVPYKD LPVILPDDVN 450
    FDGHGNPLDH HPSWKHVNCP KCDKPAVRET DTFDTFFESS WYFMRYCNSN 500
    ATEMTDKKAC DYWLPVDKYI GGIEHAVMHL LYARFFTKVM NEQNYVSVRE 550
    PFKGLFTQGM VLHATYKDEH NNWLYPEEVV KKGNEFFHKE SNNRVVQGRI 600
    EKMSKSKKNL IDLETMQEQY GADAIRLFVL SDSPPEKDLE WSASGIEGCS 650
    RFINKLEYMF KAIDSLKDDV NSEVNKELNR LVHFTIKHVA EDIKHFALNR 700
    AIARMRELSN AISAEISKDK IDVKTVRHGF NVLVQLLNPF IPHITEEIWQ 750
    KLGNKERLYN LSFPAFDESM LELDTYIMAV QVNGKLRDTY EFKTSVSEDE 800
    IKQVTVSLPK VQKFLEGQEP KKIILVPRKI VNILV 835
    Length:835
    Mass (Da):96,747
    Last modified:June 16, 2009 - v1
    Checksum:i43014F5B9EC39ABE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001612 Genomic DNA. Translation: ACP53457.1.
    RefSeqiWP_012719678.1. NC_012633.1.
    YP_002845200.1. NC_012633.1.

    Genome annotation databases

    EnsemblBacteriaiACP53457; ACP53457; RAF_ORF0546.
    GeneIDi7814963.
    KEGGiraf:RAF_ORF0546.
    PATRICi17873048. VBIRicAfr6986_0659.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001612 Genomic DNA. Translation: ACP53457.1 .
    RefSeqi WP_012719678.1. NC_012633.1.
    YP_002845200.1. NC_012633.1.

    3D structure databases

    ProteinModelPortali C3PNE7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 347255.RAF_ORF0546.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACP53457 ; ACP53457 ; RAF_ORF0546 .
    GeneIDi 7814963.
    KEGGi raf:RAF_ORF0546.
    PATRICi 17873048. VBIRicAfr6986_0659.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci RAFR347255:GJCT-511-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the Rickettsia africae genome reveals that virulence acquisition in Rickettsia species may be explained by genome reduction."
      Fournier P.-E., El Karkouri K., Leroy Q., Robert C., Giumelli B., Renesto P., Socolovschi C., Parola P., Audic S., Raoult D.
      BMC Genomics 10:166-166(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ESF-5.

    Entry informationi

    Entry nameiSYL_RICAE
    AccessioniPrimary (citable) accession number: C3PNE7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3