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Protein

Lipoprotein signal peptidase

Gene

lspA

Organism
Rickettsia africae (strain ESF-5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This protein specifically catalyzes the removal of signal peptides from prolipoproteins.UniRule annotation

Catalytic activityi

Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei117 – 1171UniRule annotation
Active sitei144 – 1441UniRule annotation

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

BioCyciRAFR347255:GJCT-492-MONOMER.
UniPathwayiUPA00665.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoprotein signal peptidaseUniRule annotation (EC:3.4.23.36UniRule annotation)
Alternative name(s):
Prolipoprotein signal peptidaseUniRule annotation
Signal peptidase IIUniRule annotation
Short name:
SPase IIUniRule annotation
Gene namesi
Name:lspAUniRule annotation
Ordered Locus Names:RAF_ORF0520
OrganismiRickettsia africae (strain ESF-5)
Taxonomic identifieri347255 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000002305: Chromosome

Subcellular locationi

Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei73 – 9321HelicalUniRule annotationAdd
BLAST
Transmembranei97 – 11721HelicalUniRule annotationAdd
BLAST
Transmembranei135 – 15521HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201Lipoprotein signal peptidasePRO_1000203595Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi347255.RAF_ORF0520.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A8 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0597.
HOGENOMiHOG000096992.
KOiK03101.
OMAiGNTEHRT.
OrthoDBiEOG6PGKBM.

Family and domain databases

HAMAPiMF_00161. LspA.
InterProiIPR001872. Peptidase_A8.
[Graphical view]
PfamiPF01252. Peptidase_A8. 1 hit.
[Graphical view]
PRINTSiPR00781. LIPOSIGPTASE.
TIGRFAMsiTIGR00077. lspA. 1 hit.
PROSITEiPS00855. SPASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3PND1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLLKKLYL TFARSSRIII TLVIIDQLSK WWFIDNLRWK PDLMLKFTSF
60 70 80 90 100
LNMVYTWNYG ISFGLMREYY QYSNAIFLIT NTIIVCYLYY LMIRSKTIGS
110 120 130 140 150
FAGYSFVIGG AVGNLIDRFF RGAVFDFIHF HYQNYSFPVF NLADCFITIG
160 170 180 190 200
VIILIEDYYS TKKVIEEKAK GNYDNAQIEA MAEKIRNTDK GGNDKIASLQ

N
Length:201
Mass (Da):23,483
Last modified:June 16, 2009 - v1
Checksum:i00A080A03DA9139D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001612 Genomic DNA. Translation: ACP53441.1.
RefSeqiYP_002845184.1. NC_012633.1.

Genome annotation databases

EnsemblBacteriaiACP53441; ACP53441; RAF_ORF0520.
GeneIDi7814944.
KEGGiraf:RAF_ORF0520.
PATRICi17872982. VBIRicAfr6986_0626.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001612 Genomic DNA. Translation: ACP53441.1.
RefSeqiYP_002845184.1. NC_012633.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi347255.RAF_ORF0520.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACP53441; ACP53441; RAF_ORF0520.
GeneIDi7814944.
KEGGiraf:RAF_ORF0520.
PATRICi17872982. VBIRicAfr6986_0626.

Phylogenomic databases

eggNOGiCOG0597.
HOGENOMiHOG000096992.
KOiK03101.
OMAiGNTEHRT.
OrthoDBiEOG6PGKBM.

Enzyme and pathway databases

UniPathwayiUPA00665.
BioCyciRAFR347255:GJCT-492-MONOMER.

Family and domain databases

HAMAPiMF_00161. LspA.
InterProiIPR001872. Peptidase_A8.
[Graphical view]
PfamiPF01252. Peptidase_A8. 1 hit.
[Graphical view]
PRINTSiPR00781. LIPOSIGPTASE.
TIGRFAMsiTIGR00077. lspA. 1 hit.
PROSITEiPS00855. SPASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Analysis of the Rickettsia africae genome reveals that virulence acquisition in Rickettsia species may be explained by genome reduction."
    Fournier P.-E., El Karkouri K., Leroy Q., Robert C., Giumelli B., Renesto P., Socolovschi C., Parola P., Audic S., Raoult D.
    BMC Genomics 10:166-166(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ESF-5.

Entry informationi

Entry nameiLSPA_RICAE
AccessioniPrimary (citable) accession number: C3PND1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: February 4, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.