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C3PND1

- LSPA_RICAE

UniProt

C3PND1 - LSPA_RICAE

Protein

Lipoprotein signal peptidase

Gene

lspA

Organism
Rickettsia africae (strain ESF-5)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    This protein specifically catalyzes the removal of signal peptides from prolipoproteins.UniRule annotation

    Catalytic activityi

    Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei117 – 1171UniRule annotation
    Active sitei144 – 1441UniRule annotation

    GO - Molecular functioni

    1. aspartic-type endopeptidase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aspartyl protease, Hydrolase, Protease

    Enzyme and pathway databases

    BioCyciRAFR347255:GJCT-492-MONOMER.
    UniPathwayiUPA00665.

    Protein family/group databases

    MEROPSiA08.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipoprotein signal peptidaseUniRule annotation (EC:3.4.23.36UniRule annotation)
    Alternative name(s):
    Prolipoprotein signal peptidaseUniRule annotation
    Signal peptidase IIUniRule annotation
    Short name:
    SPase IIUniRule annotation
    Gene namesi
    Name:lspAUniRule annotation
    Ordered Locus Names:RAF_ORF0520
    OrganismiRickettsia africae (strain ESF-5)
    Taxonomic identifieri347255 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000002305: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 201201Lipoprotein signal peptidasePRO_1000203595Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi347255.RAF_ORF0520.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei73 – 9321HelicalUniRule annotationAdd
    BLAST
    Transmembranei97 – 11721HelicalUniRule annotationAdd
    BLAST
    Transmembranei135 – 15521HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase A8 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0597.
    HOGENOMiHOG000096992.
    KOiK03101.
    OMAiGNTEHRT.
    OrthoDBiEOG6PGKBM.

    Family and domain databases

    HAMAPiMF_00161. LspA.
    InterProiIPR001872. Peptidase_A8.
    [Graphical view]
    PfamiPF01252. Peptidase_A8. 1 hit.
    [Graphical view]
    PRINTSiPR00781. LIPOSIGPTASE.
    TIGRFAMsiTIGR00077. lspA. 1 hit.
    PROSITEiPS00855. SPASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C3PND1-1 [UniParc]FASTAAdd to Basket

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    MLPLLKKLYL TFARSSRIII TLVIIDQLSK WWFIDNLRWK PDLMLKFTSF    50
    LNMVYTWNYG ISFGLMREYY QYSNAIFLIT NTIIVCYLYY LMIRSKTIGS 100
    FAGYSFVIGG AVGNLIDRFF RGAVFDFIHF HYQNYSFPVF NLADCFITIG 150
    VIILIEDYYS TKKVIEEKAK GNYDNAQIEA MAEKIRNTDK GGNDKIASLQ 200
    N 201
    Length:201
    Mass (Da):23,483
    Last modified:June 16, 2009 - v1
    Checksum:i00A080A03DA9139D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001612 Genomic DNA. Translation: ACP53441.1.
    RefSeqiYP_002845184.1. NC_012633.1.

    Genome annotation databases

    EnsemblBacteriaiACP53441; ACP53441; RAF_ORF0520.
    GeneIDi7814944.
    KEGGiraf:RAF_ORF0520.
    PATRICi17872982. VBIRicAfr6986_0626.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001612 Genomic DNA. Translation: ACP53441.1 .
    RefSeqi YP_002845184.1. NC_012633.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 347255.RAF_ORF0520.

    Protein family/group databases

    MEROPSi A08.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACP53441 ; ACP53441 ; RAF_ORF0520 .
    GeneIDi 7814944.
    KEGGi raf:RAF_ORF0520.
    PATRICi 17872982. VBIRicAfr6986_0626.

    Phylogenomic databases

    eggNOGi COG0597.
    HOGENOMi HOG000096992.
    KOi K03101.
    OMAi GNTEHRT.
    OrthoDBi EOG6PGKBM.

    Enzyme and pathway databases

    UniPathwayi UPA00665 .
    BioCyci RAFR347255:GJCT-492-MONOMER.

    Family and domain databases

    HAMAPi MF_00161. LspA.
    InterProi IPR001872. Peptidase_A8.
    [Graphical view ]
    Pfami PF01252. Peptidase_A8. 1 hit.
    [Graphical view ]
    PRINTSi PR00781. LIPOSIGPTASE.
    TIGRFAMsi TIGR00077. lspA. 1 hit.
    PROSITEi PS00855. SPASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the Rickettsia africae genome reveals that virulence acquisition in Rickettsia species may be explained by genome reduction."
      Fournier P.-E., El Karkouri K., Leroy Q., Robert C., Giumelli B., Renesto P., Socolovschi C., Parola P., Audic S., Raoult D.
      BMC Genomics 10:166-166(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ESF-5.

    Entry informationi

    Entry nameiLSPA_RICAE
    AccessioniPrimary (citable) accession number: C3PND1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3