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Protein

Lipoprotein signal peptidase

Gene

lspA

Organism
Rickettsia africae (strain ESF-5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein specifically catalyzes the removal of signal peptides from prolipoproteins.UniRule annotation

Catalytic activityi

Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.UniRule annotation

Pathwayi: lipoprotein biosynthesis (signal peptide cleavage)

This protein is involved in the pathway lipoprotein biosynthesis (signal peptide cleavage), which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway lipoprotein biosynthesis (signal peptide cleavage) and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei117UniRule annotation1
Active sitei144UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

BioCyciRAFR347255:G1GVG-889-MONOMER
UniPathwayiUPA00665

Protein family/group databases

MEROPSiA08.001

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoprotein signal peptidaseUniRule annotation (EC:3.4.23.36UniRule annotation)
Alternative name(s):
Prolipoprotein signal peptidaseUniRule annotation
Signal peptidase IIUniRule annotation
Short name:
SPase IIUniRule annotation
Gene namesi
Name:lspAUniRule annotation
Ordered Locus Names:RAF_ORF0520
OrganismiRickettsia africae (strain ESF-5)
Taxonomic identifieri347255 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000002305 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei73 – 93HelicalUniRule annotationAdd BLAST21
Transmembranei97 – 117HelicalUniRule annotationAdd BLAST21
Transmembranei135 – 155HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002035951 – 201Lipoprotein signal peptidaseAdd BLAST201

Structurei

3D structure databases

SMRiC3PND1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A8 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000096992
KOiK03101
OMAiGFDFAIF

Family and domain databases

HAMAPiMF_00161 LspA, 1 hit
InterProiView protein in InterPro
IPR001872 Peptidase_A8
PANTHERiPTHR33695 PTHR33695, 1 hit
PfamiView protein in Pfam
PF01252 Peptidase_A8, 1 hit
PRINTSiPR00781 LIPOSIGPTASE
TIGRFAMsiTIGR00077 lspA, 1 hit
PROSITEiView protein in PROSITE
PS00855 SPASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

C3PND1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLLKKLYL TFARSSRIII TLVIIDQLSK WWFIDNLRWK PDLMLKFTSF
60 70 80 90 100
LNMVYTWNYG ISFGLMREYY QYSNAIFLIT NTIIVCYLYY LMIRSKTIGS
110 120 130 140 150
FAGYSFVIGG AVGNLIDRFF RGAVFDFIHF HYQNYSFPVF NLADCFITIG
160 170 180 190 200
VIILIEDYYS TKKVIEEKAK GNYDNAQIEA MAEKIRNTDK GGNDKIASLQ

N
Length:201
Mass (Da):23,483
Last modified:June 16, 2009 - v1
Checksum:i00A080A03DA9139D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001612 Genomic DNA Translation: ACP53441.1
RefSeqiWP_012719664.1, NC_012633.1

Genome annotation databases

EnsemblBacteriaiACP53441; ACP53441; RAF_ORF0520
KEGGiraf:RAF_ORF0520

Similar proteinsi

Entry informationi

Entry nameiLSPA_RICAE
AccessioniPrimary (citable) accession number: C3PND1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: March 28, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health