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C3PND1

- LSPA_RICAE

UniProt

C3PND1 - LSPA_RICAE

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Protein
Lipoprotein signal peptidase
Gene
lspA, RAF_ORF0520
Organism
Rickettsia africae (strain ESF-5)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This protein specifically catalyzes the removal of signal peptides from prolipoproteins By similarity.UniRule annotation

Catalytic activityi

Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei117 – 1171 By similarity
Active sitei144 – 1441 By similarity

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

BioCyciRAFR347255:GJCT-492-MONOMER.
UniPathwayiUPA00665.

Protein family/group databases

MEROPSiA08.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoprotein signal peptidase (EC:3.4.23.36)
Alternative name(s):
Prolipoprotein signal peptidase
Signal peptidase II
Short name:
SPase II
Gene namesi
Name:lspA
Ordered Locus Names:RAF_ORF0520
OrganismiRickettsia africae (strain ESF-5)
Taxonomic identifieri347255 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000002305: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei73 – 9321Helical; Reviewed prediction
Add
BLAST
Transmembranei97 – 11721Helical; Reviewed prediction
Add
BLAST
Transmembranei135 – 15521Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201Lipoprotein signal peptidaseUniRule annotation
PRO_1000203595Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi347255.RAF_ORF0520.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A8 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0597.
HOGENOMiHOG000096992.
KOiK03101.
OMAiGNTEHRT.
OrthoDBiEOG6PGKBM.

Family and domain databases

HAMAPiMF_00161. LspA.
InterProiIPR001872. Peptidase_A8.
[Graphical view]
PfamiPF01252. Peptidase_A8. 1 hit.
[Graphical view]
PRINTSiPR00781. LIPOSIGPTASE.
TIGRFAMsiTIGR00077. lspA. 1 hit.
PROSITEiPS00855. SPASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3PND1-1 [UniParc]FASTAAdd to Basket

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MLPLLKKLYL TFARSSRIII TLVIIDQLSK WWFIDNLRWK PDLMLKFTSF    50
LNMVYTWNYG ISFGLMREYY QYSNAIFLIT NTIIVCYLYY LMIRSKTIGS 100
FAGYSFVIGG AVGNLIDRFF RGAVFDFIHF HYQNYSFPVF NLADCFITIG 150
VIILIEDYYS TKKVIEEKAK GNYDNAQIEA MAEKIRNTDK GGNDKIASLQ 200
N 201
Length:201
Mass (Da):23,483
Last modified:June 16, 2009 - v1
Checksum:i00A080A03DA9139D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001612 Genomic DNA. Translation: ACP53441.1.
RefSeqiYP_002845184.1. NC_012633.1.

Genome annotation databases

EnsemblBacteriaiACP53441; ACP53441; RAF_ORF0520.
GeneIDi7814944.
KEGGiraf:RAF_ORF0520.
PATRICi17872982. VBIRicAfr6986_0626.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001612 Genomic DNA. Translation: ACP53441.1 .
RefSeqi YP_002845184.1. NC_012633.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 347255.RAF_ORF0520.

Protein family/group databases

MEROPSi A08.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACP53441 ; ACP53441 ; RAF_ORF0520 .
GeneIDi 7814944.
KEGGi raf:RAF_ORF0520.
PATRICi 17872982. VBIRicAfr6986_0626.

Phylogenomic databases

eggNOGi COG0597.
HOGENOMi HOG000096992.
KOi K03101.
OMAi GNTEHRT.
OrthoDBi EOG6PGKBM.

Enzyme and pathway databases

UniPathwayi UPA00665 .
BioCyci RAFR347255:GJCT-492-MONOMER.

Family and domain databases

HAMAPi MF_00161. LspA.
InterProi IPR001872. Peptidase_A8.
[Graphical view ]
Pfami PF01252. Peptidase_A8. 1 hit.
[Graphical view ]
PRINTSi PR00781. LIPOSIGPTASE.
TIGRFAMsi TIGR00077. lspA. 1 hit.
PROSITEi PS00855. SPASE_II. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of the Rickettsia africae genome reveals that virulence acquisition in Rickettsia species may be explained by genome reduction."
    Fournier P.-E., El Karkouri K., Leroy Q., Robert C., Giumelli B., Renesto P., Socolovschi C., Parola P., Audic S., Raoult D.
    BMC Genomics 10:166-166(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ESF-5.

Entry informationi

Entry nameiLSPA_RICAE
AccessioniPrimary (citable) accession number: C3PND1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: May 14, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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