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C3PN92

- MDH_RICAE

UniProt

C3PN92 - MDH_RICAE

Protein

Malate dehydrogenase

Gene

mdh

Organism
Rickettsia africae (strain ESF-5)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei35 – 351NADUniRule annotation
    Binding sitei84 – 841SubstrateUniRule annotation
    Binding sitei90 – 901SubstrateUniRule annotation
    Binding sitei97 – 971NADUniRule annotation
    Binding sitei122 – 1221SubstrateUniRule annotation
    Binding sitei153 – 1531SubstrateUniRule annotation
    Active sitei177 – 1771Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 166NADUniRule annotation
    Nucleotide bindingi120 – 1223NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciRAFR347255:GJCT-451-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:RAF_ORF0481
    OrganismiRickettsia africae (strain ESF-5)
    Taxonomic identifieri347255 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000002305: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Malate dehydrogenasePRO_1000206445Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi347255.RAF_ORF0481.

    Structurei

    3D structure databases

    ProteinModelPortaliC3PN92.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213794.
    KOiK00024.
    OMAiYGQNDIC.
    OrthoDBiEOG6091FG.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C3PN92-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKQNPKISLI GSGNIGGTLA HLISLRELGD IVLFDVTEGV PQGKALDLMQ    50
    AGTIAGSDIN IKGTNDYKDI EGSDAIIITA GLPRKPGMSR EDLISINTGI 100
    MKTVAANVKK YAPDAFVIVI TNPLDVMVYV MLKESGLPHN KVIGMAGVLD 150
    SSRFNLFLAE EFKVSVSNVN SMVLGGHGDA MVPLARYSTI SGVPIPDLIK 200
    MGLSSNENIE KIIDRTRNGG GEIVALLKTG SAYYAPAASA IEMLESYLKD 250
    KRQILTCAAH LQGEYGVHDL YVGVPIMIGK EGVLRVIELQ LTTEEKALFD 300
    KSVEGVKKLI ETIK 314
    Length:314
    Mass (Da):33,653
    Last modified:June 16, 2009 - v1
    Checksum:iD3F66A98E3A00418
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001612 Genomic DNA. Translation: ACP53402.1.
    RefSeqiYP_002845145.1. NC_012633.1.

    Genome annotation databases

    EnsemblBacteriaiACP53402; ACP53402; RAF_ORF0481.
    GeneIDi7815545.
    KEGGiraf:RAF_ORF0481.
    PATRICi17872891. VBIRicAfr6986_0583.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001612 Genomic DNA. Translation: ACP53402.1 .
    RefSeqi YP_002845145.1. NC_012633.1.

    3D structure databases

    ProteinModelPortali C3PN92.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 347255.RAF_ORF0481.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACP53402 ; ACP53402 ; RAF_ORF0481 .
    GeneIDi 7815545.
    KEGGi raf:RAF_ORF0481.
    PATRICi 17872891. VBIRicAfr6986_0583.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213794.
    KOi K00024.
    OMAi YGQNDIC.
    OrthoDBi EOG6091FG.

    Enzyme and pathway databases

    BioCyci RAFR347255:GJCT-451-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the Rickettsia africae genome reveals that virulence acquisition in Rickettsia species may be explained by genome reduction."
      Fournier P.-E., El Karkouri K., Leroy Q., Robert C., Giumelli B., Renesto P., Socolovschi C., Parola P., Audic S., Raoult D.
      BMC Genomics 10:166-166(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ESF-5.

    Entry informationi

    Entry nameiMDH_RICAE
    AccessioniPrimary (citable) accession number: C3PN92
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3