Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

C3PKU4

- SYL_CORA7

UniProt

C3PKU4 - SYL_CORA7

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Corynebacterium aurimucosum (strain ATCC 700975 / DSM 44827 / CN-1) (Corynebacterium nigricans)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei722 – 7221ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCAUR548476:GH9E-2532-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:cauri_2469
    OrganismiCorynebacterium aurimucosum (strain ATCC 700975 / DSM 44827 / CN-1) (Corynebacterium nigricans)
    Taxonomic identifieri548476 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000002077: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 949949Leucine--tRNA ligasePRO_1000199188Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi169292.cauri_2469.

    Structurei

    3D structure databases

    ProteinModelPortaliC3PKU4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi62 – 7312"HIGH" regionAdd
    BLAST
    Motifi719 – 7235"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiYARYHRM.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C3PKU4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNPSDNTTH RYTPELAAQI ESAWQQYWKD NGTFNAPNPV GPLAEEGKEL    50
    PAEKMNIQDM FPYPSGAGLH VGHPLGYIAT DTYARFNRML GKNVLHTLGY 100
    DAFGLPAEQY AIQTGTHPRT TTEANINNMR RQLGMLGLGH DPRRSVASTD 150
    PEFYKWTQWI FLQIYNSWFD EEQQKARPIS ELIKELEVGK RTTKDGRYYA 200
    DLTKEEQRQA LDEFRLVYLS NSTVNWCPGL GTVLANEEVT AEGKSERGNF 250
    PVFRKNLRQW MMRITAYSDR LLDDLELLDW PEKVKSMQRN WIGRSRGAEV 300
    SFHAEGYNID VFTTRPDTLF GAEYVVLAPE HELVDALLSP IPYEDDVDKR 350
    WTFGHDDPKE AVEAYRASIA AKSDLERQEN KEKTGVFLGT YATNPVNGKQ 400
    IPIFIADYVL TGYGTGAIMA VPAHDTRDYE FATVFGLPIT EVVAGGDITK 450
    EAYTESGQAV NSANDSLDIN GMSKDEAIAT IIPWLEEQGV GREKIQYKLR 500
    DWLFARQRYW GEPFPIVYDE AGQAYPLPES MLPIELPEVE DYKPVSFDPD 550
    DADSSPQPPL AKAREWVEVE LDLGLGDGPK TYYRDTNVMP QWAGSSWYQL 600
    RYIDPTNDEI FCDLENERYW TGPRTEEHGA NDPGGVDLYV GGVEHAVLHL 650
    LYARFWHKVL FDLGYVSSKE PYRRLYNQGY IQAYAYTDSR GVYVPAAEVE 700
    EKDGKFYYNG EEVNQEYGKM GKSLKNSVAP DDICRDYGAD TLRVYEMSMG 750
    PLDTSRPWAT KDVVGAQRFL QRLWRLAIDE NSGELSTTDA ELSEDDLKHL 800
    NRTIAGVRDD YENLRLNTVV AKLIEYVNYL TKAYPKGAPR AAVEPLAQLV 850
    SPVAPHIAEE LWKRFGHEGT ITYEAFPEFD EKYLVDDEIE VPVQINGKVK 900
    ARVMVPADAD QATVVGIAKD DERIAELTAG KNVVKEIYVP GRMVNLVVK 949
    Length:949
    Mass (Da):107,536
    Last modified:June 16, 2009 - v1
    Checksum:i740B6BD315B1ECE1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001601 Genomic DNA. Translation: ACP34060.1.
    RefSeqiYP_002835998.1. NC_012590.1.

    Genome annotation databases

    EnsemblBacteriaiACP34060; ACP34060; cauri_2469.
    GeneIDi7801606.
    KEGGicar:cauri_2469.
    PATRICi21481014. VBICorAur68407_2501.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001601 Genomic DNA. Translation: ACP34060.1 .
    RefSeqi YP_002835998.1. NC_012590.1.

    3D structure databases

    ProteinModelPortali C3PKU4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 169292.cauri_2469.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACP34060 ; ACP34060 ; cauri_2469 .
    GeneIDi 7801606.
    KEGGi car:cauri_2469.
    PATRICi 21481014. VBICorAur68407_2501.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi YARYHRM.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CAUR548476:GH9E-2532-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence and lifestyle of black-pigmented Corynebacterium aurimucosum ATCC 700975 (formerly C. nigricans CN-1) isolated from a vaginal swab of a woman with spontaneous abortion."
      Trost E., Gotker S., Schneider J., Schneiker-Bekel S., Szczepanowski R., Tilker A., Viehoever P., Arnold W., Bekel T., Blom J., Gartemann K.H., Linke B., Goesmann A., Puhler A., Shukla S.K., Tauch A.
      BMC Genomics 11:91-91(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700975 / DSM 44827 / CN-1.

    Entry informationi

    Entry nameiSYL_CORA7
    AccessioniPrimary (citable) accession number: C3PKU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3