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C3PKU4

- SYL_CORA7

UniProt

C3PKU4 - SYL_CORA7

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Protein

Leucine--tRNA ligase

Gene
leuS, cauri_2469
Organism
Corynebacterium aurimucosum (strain ATCC 700975 / DSM 44827 / CN-1) (Corynebacterium nigricans)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei722 – 7221ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCAUR548476:GH9E-2532-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:cauri_2469
OrganismiCorynebacterium aurimucosum (strain ATCC 700975 / DSM 44827 / CN-1) (Corynebacterium nigricans)
Taxonomic identifieri548476 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000002077: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 949949Leucine--tRNA ligaseUniRule annotationPRO_1000199188Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi169292.cauri_2469.

Structurei

3D structure databases

ProteinModelPortaliC3PKU4.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi62 – 7312"HIGH" regionUniRule annotationAdd
BLAST
Motifi719 – 7235"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiYARYHRM.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3PKU4-1 [UniParc]FASTAAdd to Basket

« Hide

MTNPSDNTTH RYTPELAAQI ESAWQQYWKD NGTFNAPNPV GPLAEEGKEL    50
PAEKMNIQDM FPYPSGAGLH VGHPLGYIAT DTYARFNRML GKNVLHTLGY 100
DAFGLPAEQY AIQTGTHPRT TTEANINNMR RQLGMLGLGH DPRRSVASTD 150
PEFYKWTQWI FLQIYNSWFD EEQQKARPIS ELIKELEVGK RTTKDGRYYA 200
DLTKEEQRQA LDEFRLVYLS NSTVNWCPGL GTVLANEEVT AEGKSERGNF 250
PVFRKNLRQW MMRITAYSDR LLDDLELLDW PEKVKSMQRN WIGRSRGAEV 300
SFHAEGYNID VFTTRPDTLF GAEYVVLAPE HELVDALLSP IPYEDDVDKR 350
WTFGHDDPKE AVEAYRASIA AKSDLERQEN KEKTGVFLGT YATNPVNGKQ 400
IPIFIADYVL TGYGTGAIMA VPAHDTRDYE FATVFGLPIT EVVAGGDITK 450
EAYTESGQAV NSANDSLDIN GMSKDEAIAT IIPWLEEQGV GREKIQYKLR 500
DWLFARQRYW GEPFPIVYDE AGQAYPLPES MLPIELPEVE DYKPVSFDPD 550
DADSSPQPPL AKAREWVEVE LDLGLGDGPK TYYRDTNVMP QWAGSSWYQL 600
RYIDPTNDEI FCDLENERYW TGPRTEEHGA NDPGGVDLYV GGVEHAVLHL 650
LYARFWHKVL FDLGYVSSKE PYRRLYNQGY IQAYAYTDSR GVYVPAAEVE 700
EKDGKFYYNG EEVNQEYGKM GKSLKNSVAP DDICRDYGAD TLRVYEMSMG 750
PLDTSRPWAT KDVVGAQRFL QRLWRLAIDE NSGELSTTDA ELSEDDLKHL 800
NRTIAGVRDD YENLRLNTVV AKLIEYVNYL TKAYPKGAPR AAVEPLAQLV 850
SPVAPHIAEE LWKRFGHEGT ITYEAFPEFD EKYLVDDEIE VPVQINGKVK 900
ARVMVPADAD QATVVGIAKD DERIAELTAG KNVVKEIYVP GRMVNLVVK 949
Length:949
Mass (Da):107,536
Last modified:June 16, 2009 - v1
Checksum:i740B6BD315B1ECE1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001601 Genomic DNA. Translation: ACP34060.1.
RefSeqiYP_002835998.1. NC_012590.1.

Genome annotation databases

EnsemblBacteriaiACP34060; ACP34060; cauri_2469.
GeneIDi7801606.
KEGGicar:cauri_2469.
PATRICi21481014. VBICorAur68407_2501.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001601 Genomic DNA. Translation: ACP34060.1 .
RefSeqi YP_002835998.1. NC_012590.1.

3D structure databases

ProteinModelPortali C3PKU4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 169292.cauri_2469.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACP34060 ; ACP34060 ; cauri_2469 .
GeneIDi 7801606.
KEGGi car:cauri_2469.
PATRICi 21481014. VBICorAur68407_2501.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi YARYHRM.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CAUR548476:GH9E-2532-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence and lifestyle of black-pigmented Corynebacterium aurimucosum ATCC 700975 (formerly C. nigricans CN-1) isolated from a vaginal swab of a woman with spontaneous abortion."
    Trost E., Gotker S., Schneider J., Schneiker-Bekel S., Szczepanowski R., Tilker A., Viehoever P., Arnold W., Bekel T., Blom J., Gartemann K.H., Linke B., Goesmann A., Puhler A., Shukla S.K., Tauch A.
    BMC Genomics 11:91-91(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700975 / DSM 44827 / CN-1.

Entry informationi

Entry nameiSYL_CORA7
AccessioniPrimary (citable) accession number: C3PKU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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