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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Corynebacterium aurimucosum (strain ATCC 700975 / DSM 44827 / CN-1) (Corynebacterium nigricans)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei722 – 7221ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCAUR548476:GH9E-2532-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:cauri_2469
OrganismiCorynebacterium aurimucosum (strain ATCC 700975 / DSM 44827 / CN-1) (Corynebacterium nigricans)
Taxonomic identifieri548476 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
ProteomesiUP000002077 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 949949Leucine--tRNA ligasePRO_1000199188Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi548476.CaurA7_010100003432.

Structurei

3D structure databases

ProteinModelPortaliC3PKU4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi62 – 7312"HIGH" regionAdd
BLAST
Motifi719 – 7235"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3PKU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNPSDNTTH RYTPELAAQI ESAWQQYWKD NGTFNAPNPV GPLAEEGKEL
60 70 80 90 100
PAEKMNIQDM FPYPSGAGLH VGHPLGYIAT DTYARFNRML GKNVLHTLGY
110 120 130 140 150
DAFGLPAEQY AIQTGTHPRT TTEANINNMR RQLGMLGLGH DPRRSVASTD
160 170 180 190 200
PEFYKWTQWI FLQIYNSWFD EEQQKARPIS ELIKELEVGK RTTKDGRYYA
210 220 230 240 250
DLTKEEQRQA LDEFRLVYLS NSTVNWCPGL GTVLANEEVT AEGKSERGNF
260 270 280 290 300
PVFRKNLRQW MMRITAYSDR LLDDLELLDW PEKVKSMQRN WIGRSRGAEV
310 320 330 340 350
SFHAEGYNID VFTTRPDTLF GAEYVVLAPE HELVDALLSP IPYEDDVDKR
360 370 380 390 400
WTFGHDDPKE AVEAYRASIA AKSDLERQEN KEKTGVFLGT YATNPVNGKQ
410 420 430 440 450
IPIFIADYVL TGYGTGAIMA VPAHDTRDYE FATVFGLPIT EVVAGGDITK
460 470 480 490 500
EAYTESGQAV NSANDSLDIN GMSKDEAIAT IIPWLEEQGV GREKIQYKLR
510 520 530 540 550
DWLFARQRYW GEPFPIVYDE AGQAYPLPES MLPIELPEVE DYKPVSFDPD
560 570 580 590 600
DADSSPQPPL AKAREWVEVE LDLGLGDGPK TYYRDTNVMP QWAGSSWYQL
610 620 630 640 650
RYIDPTNDEI FCDLENERYW TGPRTEEHGA NDPGGVDLYV GGVEHAVLHL
660 670 680 690 700
LYARFWHKVL FDLGYVSSKE PYRRLYNQGY IQAYAYTDSR GVYVPAAEVE
710 720 730 740 750
EKDGKFYYNG EEVNQEYGKM GKSLKNSVAP DDICRDYGAD TLRVYEMSMG
760 770 780 790 800
PLDTSRPWAT KDVVGAQRFL QRLWRLAIDE NSGELSTTDA ELSEDDLKHL
810 820 830 840 850
NRTIAGVRDD YENLRLNTVV AKLIEYVNYL TKAYPKGAPR AAVEPLAQLV
860 870 880 890 900
SPVAPHIAEE LWKRFGHEGT ITYEAFPEFD EKYLVDDEIE VPVQINGKVK
910 920 930 940
ARVMVPADAD QATVVGIAKD DERIAELTAG KNVVKEIYVP GRMVNLVVK
Length:949
Mass (Da):107,536
Last modified:June 16, 2009 - v1
Checksum:i740B6BD315B1ECE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001601 Genomic DNA. Translation: ACP34060.1.
RefSeqiWP_010187942.1. NZ_ACLH01000027.1.
YP_002835998.1. NC_012590.1.

Genome annotation databases

EnsemblBacteriaiACP34060; ACP34060; cauri_2469.
KEGGicar:cauri_2469.
PATRICi21481014. VBICorAur68407_2501.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001601 Genomic DNA. Translation: ACP34060.1.
RefSeqiWP_010187942.1. NZ_ACLH01000027.1.
YP_002835998.1. NC_012590.1.

3D structure databases

ProteinModelPortaliC3PKU4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi548476.CaurA7_010100003432.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACP34060; ACP34060; cauri_2469.
KEGGicar:cauri_2469.
PATRICi21481014. VBICorAur68407_2501.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciCAUR548476:GH9E-2532-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence and lifestyle of black-pigmented Corynebacterium aurimucosum ATCC 700975 (formerly C. nigricans CN-1) isolated from a vaginal swab of a woman with spontaneous abortion."
    Trost E., Gotker S., Schneider J., Schneiker-Bekel S., Szczepanowski R., Tilker A., Viehoever P., Arnold W., Bekel T., Blom J., Gartemann K.H., Linke B., Goesmann A., Puhler A., Shukla S.K., Tauch A.
    BMC Genomics 11:91-91(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700975 / DSM 44827 / CN-1.

Entry informationi

Entry nameiSYL_CORA7
AccessioniPrimary (citable) accession number: C3PKU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: June 24, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.