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Protein

D-inositol 3-phosphate glycosyltransferase

Gene

mshA

Organism
Corynebacterium aurimucosum (strain ATCC 700975 / DSM 44827 / CN-1) (Corynebacterium nigricans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.UniRule annotation

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate = UDP + 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei91D-inositol 3-phosphateUniRule annotation1
Binding sitei23UDP-GlcNAc; via amide nitrogenUniRule annotation1
Binding sitei781D-inositol 3-phosphateUniRule annotation1
Binding sitei1101D-inositol 3-phosphateUniRule annotation1
Binding sitei1341D-inositol 3-phosphateUniRule annotation1
Binding sitei1541D-inositol 3-phosphateUniRule annotation1
Binding sitei231UDP-GlcNAcUniRule annotation1
Binding sitei236UDP-GlcNAcUniRule annotation1
Binding sitei294UDP-GlcNAc; via amide nitrogen and carbonyl oxygenUniRule annotation1
Metal bindingi303Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi304Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi306Magnesium; via carbonyl oxygenUniRule annotation1
Binding sitei316UDP-GlcNAcUniRule annotation1
Binding sitei324UDP-GlcNAcUniRule annotation1
Metal bindingi330MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
D-inositol 3-phosphate glycosyltransferase (EC:2.4.1.250UniRule annotation)
Alternative name(s):
N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferaseUniRule annotation
Short name:
GlcNAc-Ins-P N-acetylglucosaminyltransferaseUniRule annotation
Gene namesi
Name:mshAUniRule annotation
Ordered Locus Names:cauri_0284
OrganismiCorynebacterium aurimucosum (strain ATCC 700975 / DSM 44827 / CN-1) (Corynebacterium nigricans)
Taxonomic identifieri548476 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000002077 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004001151 – 421D-inositol 3-phosphate glycosyltransferaseAdd BLAST421

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi548476.CaurA7_010100008588.

Structurei

3D structure databases

ProteinModelPortaliC3PK12.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni15 – 16UDP-GlcNAc bindingUniRule annotation2
Regioni20 – 251D-inositol 3-phosphate bindingUniRule annotation6

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family. MshA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R5M. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000077288.
KOiK15521.
OMAiHTMAKVK.
OrthoDBiPOG091H0AO3.

Family and domain databases

HAMAPiMF_01695. MshA. 1 hit.
InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
IPR017814. Mycothiol_biosynthesis_MshA.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03449. mycothiol_MshA. 1 hit.

Sequencei

Sequence statusi: Complete.

C3PK12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIAMISMHT SPLEQPGSGD AGGMNVYVLN TARQLARLGV EVDIFTRATR
60 70 80 90 100
PSQGEVVDVE ERLRVINIVA GPYEGLSKEE LPTQLAAFTG GIFNFARCFE
110 120 130 140 150
VDYDVIHSHY WLSGQVGWLL RDLWDIPLVH TAHTLAAVKN VHRTLDDTPE
160 170 180 190 200
TEARRICEQQ LVDNADILVV NTAQETRDLI EHYDASPDNI VVVSPGADTD
210 220 230 240 250
LYTPGTDRMT ERARRQLGIP LHTKVVAFVG RLQKFKGPDV LIRATAELME
260 270 280 290 300
RDPDRRLRVV ICGGASGANS SPDTYHNLAR ELGVERVVRF LSPRPPQELV
310 320 330 340 350
AIYQAADIVA VPSYNESFGL VAMEAQASGT PVVAAAVGGL PIAVADGDTG
360 370 380 390 400
LLVHSHSAQD WADALEQLLD DDPRRISMGE AAVDHAQQFS WAAAATQLEN
410 420
IYADAMSIEI PDCHARRAIG Y
Length:421
Mass (Da):46,044
Last modified:June 16, 2009 - v1
Checksum:iA256BF7C7806792C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001601 Genomic DNA. Translation: ACP31883.1.
RefSeqiWP_010189828.1. NZ_ACLH01000069.1.

Genome annotation databases

EnsemblBacteriaiACP31883; ACP31883; cauri_0284.
KEGGicar:cauri_0284.
PATRICi21476508. VBICorAur68407_0305.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001601 Genomic DNA. Translation: ACP31883.1.
RefSeqiWP_010189828.1. NZ_ACLH01000069.1.

3D structure databases

ProteinModelPortaliC3PK12.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi548476.CaurA7_010100008588.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACP31883; ACP31883; cauri_0284.
KEGGicar:cauri_0284.
PATRICi21476508. VBICorAur68407_0305.

Phylogenomic databases

eggNOGiENOG4107R5M. Bacteria.
COG0438. LUCA.
HOGENOMiHOG000077288.
KOiK15521.
OMAiHTMAKVK.
OrthoDBiPOG091H0AO3.

Family and domain databases

HAMAPiMF_01695. MshA. 1 hit.
InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
IPR017814. Mycothiol_biosynthesis_MshA.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03449. mycothiol_MshA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMSHA_CORA7
AccessioniPrimary (citable) accession number: C3PK12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: June 16, 2009
Last modified: November 2, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.