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Protein

Mycothiol acetyltransferase

Gene

mshD

Organism
Corynebacterium aurimucosum (strain ATCC 700975 / DSM 44827 / CN-1) (Corynebacterium nigricans)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.UniRule annotation

Catalytic activityi

Desacetylmycothiol + acetyl-CoA = CoA + mycothiol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36Desacetylmycothiol; via amide nitrogenUniRule annotation1
Binding sitei179DesacetylmycothiolUniRule annotation1
Binding sitei225DesacetylmycothiolUniRule annotation1
Binding sitei236DesacetylmycothiolUniRule annotation1
Binding sitei274Desacetylmycothiol; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Mycothiol acetyltransferaseUniRule annotation (EC:2.3.1.189UniRule annotation)
Short name:
MSH acetyltransferaseUniRule annotation
Alternative name(s):
Mycothiol synthaseUniRule annotation
Gene namesi
Name:mshDUniRule annotation
Ordered Locus Names:cauri_2155
OrganismiCorynebacterium aurimucosum (strain ATCC 700975 / DSM 44827 / CN-1) (Corynebacterium nigricans)
Taxonomic identifieri548476 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000002077 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004002471 – 304Mycothiol acetyltransferaseAdd BLAST304

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi548476.CaurA7_010100006031.

Structurei

3D structure databases

ProteinModelPortaliC3PIU4.
SMRiC3PIU4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini145 – 304N-acetyltransferaseUniRule annotationAdd BLAST160

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni73 – 75Acetyl-CoA binding 1UniRule annotation3
Regioni240 – 242Acetyl-CoA binding 2UniRule annotation3
Regioni279 – 284Acetyl-CoA binding 2UniRule annotation6

Sequence similaritiesi

Belongs to the acetyltransferase family. MshD subfamily.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108RTV. Bacteria.
COG0456. LUCA.
HOGENOMiHOG000248937.
KOiK15520.
OMAiAEPWFDP.
OrthoDBiPOG091H09IL.

Family and domain databases

HAMAPiMF_01698. MshD. 1 hit.
InterProiView protein in InterPro
IPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR017813. Mycothiol_AcTrfase.
PfamiView protein in Pfam
PF00583. Acetyltransf_1. 1 hit.
PIRSFiPIRSF021524. MSH_acetyltransferase. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
TIGRFAMsiTIGR03448. mycothiol_MshD. 1 hit.
PROSITEiView protein in PROSITE
PS51186. GNAT. 1 hit.

Sequencei

Sequence statusi: Complete.

C3PIU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIETNTVPQ NLDLAQRVEE LAAAAETHDG VAPLSEQFLI GLRDDRLGHR
60 70 80 90 100
HLLAIEGDEV LGVAALDGQT VELFVGVDNR GRGIGKALVD ALPASPQIWA
110 120 130 140 150
HGNLPAAQAL AKRNEMDVVR RLLVMAIEGR DLRAAEEAPT TVDGLEIQTY
160 170 180 190 200
TESVERFGRE HVEAEWVRTN NEAFSWHPEQ GGWDLERLHR GMEAEWFDPA
210 220 230 240 250
DVLFLWDSHG GAHSAPTMAG FHWLKWHAED TPAFGEVYVV GLAEDYRGRG
260 270 280 290 300
LGGPLLTAGL QRMVEKGADK VILYVEADND PAVKAYERLG FSIAEEHCVW

AKSD
Length:304
Mass (Da):33,540
Last modified:June 16, 2009 - v1
Checksum:iE5867455065295D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001601 Genomic DNA. Translation: ACP33748.1.
RefSeqiWP_010189012.1. NZ_ACLH01000052.1.

Genome annotation databases

EnsemblBacteriaiACP33748; ACP33748; cauri_2155.
GeneIDi31924809.
KEGGicar:cauri_2155.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMSHD_CORA7
AccessioniPrimary (citable) accession number: C3PIU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: June 16, 2009
Last modified: July 5, 2017
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families