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C3PHZ8 (C3PHZ8_CORA7) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Gamma-glutamyl phosphate reductase HAMAP MF_00412
Short name=GPR HAMAP MF_00412
EC=1.2.1.41 HAMAP MF_00412
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase HAMAP MF_00412
Glutamyl-gamma-semialdehyde dehydrogenase HAMAP MF_00412
Gene names
Name:proA HAMAP MF_00412
Ordered Locus Names:cauri_1859
OrganismCorynebacterium aurimucosum (strain ATCC 700975 / DSM 44827 / CN-1) (Corynebacterium nigricans) [Complete proteome] [HAMAP]
Taxonomic identifier548476 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate By similarity. HAMAP MF_00412

Catalytic activity

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP MF_00412

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP MF_00412

Subcellular location

Cytoplasm By similarity HAMAP MF_00412.

Sequence similarities

Belongs to the gamma-glutamyl phosphate reductase family. HAMAP MF_00412

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Proline biosynthesis HAMAP MF_00412
   Cellular componentCytoplasm HAMAP MF_00412
   LigandNADP HAMAP MF_00412
   Molecular functionOxidoreductase HAMAP MF_00412 EMBL ACP33452.1
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processproline biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNADP binding

Inferred from electronic annotation. Source: InterPro

glutamate-5-semialdehyde dehydrogenase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
C3PHZ8 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: D6A6067310137C63

FASTA42244,987
        10         20         30         40         50         60 
MSNTEREEVL SKARAAKAVA PQFAQLPTPR KNEILNRAAE NLIAHTEDIL AANQLDIEAG 

        70         80         90        100        110        120 
RANGMSESLI DRLSLDAARI EGIAGGLRQV ASLQDPVGEI LQGRTMDNGI QMKQVRVPLG 

       130        140        150        160        170        180 
VMGMVYEARP NVTVDAFGLA LKSGNVPLLR GSKSAKNSNA KLVELLQDTL MEFDLPREGV 

       190        200        210        220        230        240 
QLLPCETHDS VQDLITARGL VDLVIPRGGA RLINAVVENA TVPAIETGTG NCHFYVDASA 

       250        260        270        280        290        300 
DLDKAIDMVI NGKTRRTSVC NATEGVLIDA ALDDASKLRI ITALQEAGVT IHSDVKELEA 

       310        320        330        340        350        360 
FGVKDAVEAT DEEWREEFLS MDICAKVVDG VDGAIAHIAE YTTGHTEAIA AQDADVLLTF 

       370        380        390        400        410        420 
ANEVDAAAVM LNASTAFTDG EVYGMGAEIG ISTQKLHARG PMALPELTST KWVLQGTGQT 


RP

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References

[1]"Complete genome sequence and lifestyle of black-pigmented Corynebacterium aurimucosum ATCC 700975 (formerly C. nigricans CN-1) isolated from a vaginal swab of a woman with spontaneous abortion."
Trost E., Gotker S., Schneider J., Schneiker-Bekel S., Szczepanowski R., Tilker A., Viehoever P., Arnold W., Bekel T., Blom J., Gartemann K.H., Linke B., Goesmann A., Puhler A., Shukla S.K., Tauch A.
BMC Genomics 11:91-91(2010) [PubMed: 20137072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700975 / DSM 44827 / CN-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001601 Genomic DNA. Translation: ACP33452.1.
RefSeqYP_002835390.1. NC_012590.1.

3D structure databases

ProteinModelPortalC3PHZ8.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7801936.
GenomeReviewsGene locus cauri_1859 in contig CP001601_GR.
KEGGcar:cauri_1859.
PATRIC21479770. VBICorAur68407_1902.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAQYPAACN.
ProtClustDBPRK00197.

Family and domain databases

HAMAPMF_00412. ProA.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00147.
PANTHERPTHR11063:SF1. GSA_DH. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFPIRSF000151. GPR. 1 hit.
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR00407. ProA. 1 hit.
PROSITEPS01223. PROA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC3PHZ8_CORA7
AccessionPrimary (citable) accession number: C3PHZ8
Entry history
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info