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C3PH09

- PNP_CORA7

UniProt

C3PH09 - PNP_CORA7

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Corynebacterium aurimucosum (strain ATCC 700975 / DSM 44827 / CN-1) (Corynebacterium nigricans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi547 – 5471MagnesiumUniRule annotation
Metal bindingi553 – 5531MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciCAUR548476:GH9E-1558-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:cauri_1520
OrganismiCorynebacterium aurimucosum (strain ATCC 700975 / DSM 44827 / CN-1) (Corynebacterium nigricans)
Taxonomic identifieri548476 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000002077: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 756756Polyribonucleotide nucleotidyltransferasePRO_0000381879Add
BLAST

Proteomic databases

PRIDEiC3PH09.

Interactioni

Protein-protein interaction databases

STRINGi169292.cauri_1520.

Structurei

3D structure databases

ProteinModelPortaliC3PH09.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini613 – 67260KHUniRule annotationAdd
BLAST
Domaini684 – 75370S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiTIAGKQD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3PH09-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAKNAKKQP NNSVEFLIDD DYGITEAIAT LDNGDFGTRT IRFETGQLAR
60 70 80 90 100
QAGGSVTTYL DEDTMLLSTT TASNQPREGF DFFPLTVDVE ERMYAAGKIP
110 120 130 140 150
GSFFRREGRP STEAILACRL IDRPLRPTFV KGLRNEVQVV VTVLSMDPEE
160 170 180 190 200
YYDVVAINGA SASTQLSGLP VSGPVGGVRM ALIADDKHPK GQWVAFPNNE
210 220 230 240 250
QHERALFEMV VAGRIVKKGR KDDVAIMMVE AGAGVNVAER IKEGAPAPQE
260 270 280 290 300
STVAEGLEAA KPFIKSLCEA QAGLAERAAK ETQEFPLFPP YGDDVYAAVE
310 320 330 340 350
KAASKKLEKL LTIPGKQDRD DATNEYMEQV EAKLIEDFDD LDEADASKQI
360 370 380 390 400
RNAFNAVMKD IVRTKILTEG FRIDGRGVTD IRDLGVEVDL IPRAHGSSLF
410 420 430 440 450
ERGETQILGV TTLDMLKMEQ QIDSLTPVES KRYMHHYNFP PYSTGETGRV
460 470 480 490 500
GSPKRREIGH GALAERALLP VIPSREDFPY AIRQVSEALG SNGSTSMGSV
510 520 530 540 550
CASTLSLYNA GVPLKAPVAG IAMGLVSGEV NGKEKFVALT DILGAEDAFG
560 570 580 590 600
DMDFKVAGTS EFITALQLDT KLDGIPSHVL ADALEQARDA RAAILDTMSE
610 620 630 640 650
VIESPDEMSG LAPRITSVTI PVNKIGELIG PKGKTINAIT EETGADVSIE
660 670 680 690 700
EDGTVYISAA TGEAADAAID RVNSIANPQL PKVGERFLGT VVKTVAFGAF
710 720 730 740 750
VSLTPGRDGL VHISKLGGDE RIEKVEDVVN VGDKIQVEIA DIDNRGKISL

VPVEED
Length:756
Mass (Da):81,419
Last modified:June 16, 2009 - v1
Checksum:i5263400B15340FAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001601 Genomic DNA. Translation: ACP33113.1.
RefSeqiWP_010190315.1. NZ_ACLH01000084.1.
YP_002835051.1. NC_012590.1.

Genome annotation databases

EnsemblBacteriaiACP33113; ACP33113; cauri_1520.
GeneIDi7800726.
KEGGicar:cauri_1520.
PATRICi21479076. VBICorAur68407_1558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001601 Genomic DNA. Translation: ACP33113.1 .
RefSeqi WP_010190315.1. NZ_ACLH01000084.1.
YP_002835051.1. NC_012590.1.

3D structure databases

ProteinModelPortali C3PH09.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 169292.cauri_1520.

Proteomic databases

PRIDEi C3PH09.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACP33113 ; ACP33113 ; cauri_1520 .
GeneIDi 7800726.
KEGGi car:cauri_1520.
PATRICi 21479076. VBICorAur68407_1558.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi TIAGKQD.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci CAUR548476:GH9E-1558-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence and lifestyle of black-pigmented Corynebacterium aurimucosum ATCC 700975 (formerly C. nigricans CN-1) isolated from a vaginal swab of a woman with spontaneous abortion."
    Trost E., Gotker S., Schneider J., Schneiker-Bekel S., Szczepanowski R., Tilker A., Viehoever P., Arnold W., Bekel T., Blom J., Gartemann K.H., Linke B., Goesmann A., Puhler A., Shukla S.K., Tauch A.
    BMC Genomics 11:91-91(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700975 / DSM 44827 / CN-1.

Entry informationi

Entry nameiPNP_CORA7
AccessioniPrimary (citable) accession number: C3PH09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 16, 2009
Last modified: November 26, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3