C3PGV9 (AHPD_CORA7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alkyl hydroperoxide reductase AhpD
EC=1.11.1.15

Alternative name(s):
Alkylhydroperoxidase AhpD

Gene names

Name:	ahpD
Ordered Locus Names:	cauri_1470

Organism

Corynebacterium aurimucosum (strain ATCC 700975 / DSM 44827 / CN-1) (Corynebacterium nigricans) [Complete proteome] [HAMAP]

Taxonomic identifier

548476 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium

Protein attributes

Sequence length	177 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity By similarity. HAMAP MF_01676
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. HAMAP MF_01676
Subunit structure	Homotrimer By similarity. HAMAP MF_01676
Sequence similarities	Belongs to the AhpD family.

Ontologies

Keywords
Domain	Redox-active center
Molecular function	Antioxidant Oxidoreductase Peroxidase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	peroxidase activity Inferred from electronic annotation. Source: UniProtKB-KW peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 177	177	Alkyl hydroperoxide reductase AhpD HAMAP MF_01676		PRO_1000187334
Sites
	Active site	130	1	Proton donor By similarity
	Active site	133	1	Cysteine sulfenic acid (-SOH) intermediate By similarity
Amino acid modifications
	Disulfide bond	130 ↔ 133		Alternate By similarity
	Disulfide bond	133		Interchain (with AhpC); in linked form By similarity

Sequences

	Sequence		Length	Mass (Da)
	C3PGV9 [UniParc]. Last modified June 16, 2009. Version 1. Checksum: 739EFCACF5EFA6A4	FASTA	177	19,013
	10 20 30 40 50 60 MSIENLKSAL PAYAKDQKLN IGSLTRSTEL NEEQLWGSLV AAAAATRNDL VLSEILEEAR 70 80 90 100 110 120 EHLSEEAVDA ALGSATVMAM NNVAYRAKSW LGDDFAQVKF GLRMNIIAKP GVDKATFELW 130 140 150 160 170 STVVSAINGC EHCLSAHANT LLEEGVTKEQ IWEGIKVAGV VEAVAQALQA EAVRSAE

References

[1]

"Complete genome sequence and lifestyle of black-pigmented Corynebacterium aurimucosum ATCC 700975 (formerly C. nigricans CN-1) isolated from a vaginal swab of a woman with spontaneous abortion." Trost E., Gotker S., Schneider J., Schneiker-Bekel S., Szczepanowski R., Tilker A., Viehoever P., Arnold W., Bekel T., Blom J., Gartemann K.H., Linke B., Goesmann A., Puhler A., Shukla S.K., Tauch A. BMC Genomics 11:91-91(2010) [PubMed: 20137072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700975 / DSM 44827 / CN-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001601 Genomic DNA. Translation: ACP33063.1.
RefSeq	YP_002835001.1. NC_012590.1.
3D structure databases
ProteinModelPortal	C3PGV9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7800676.
GenomeReviews	Gene locus cauri_1470 in contig CP001601_GR.
KEGG	car:cauri_1470.
PATRIC	21478974. VBICorAur68407_1507.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	RAGLRMN.
ProtClustDB	CLSK2485789.
Family and domain databases
HAMAP	MF_01676. AhpD. [Tree]
InterPro	IPR004674. AhpD. IPR004675. AhpD_core. IPR003779. CMD. [Graphical view]
KO	K04756.
Pfam	PF02627. CMD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00777. AhpD. 1 hit. TIGR00778. AhpD_dom. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AHPD_CORA7

Accession

Primary (citable) accession number: C3PGV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	June 16, 2009
Last modified:	January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program