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Protein

1-pyrroline-5-carboxylate dehydrogenase

Gene

rocA

Organism
Bacillus anthracis (strain A0248)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate 5-semialdehyde + NAD+ + H2O = L-glutamate + NADH.UniRule annotation

Pathway: L-proline degradation into L-glutamate

This protein is involved in step 2 of the subpathway that synthesizes L-glutamate from L-proline.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 1-pyrroline-5-carboxylate dehydrogenase (rocA)
This subpathway is part of the pathway L-proline degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate from L-proline, the pathway L-proline degradation into L-glutamate and in Amino-acid degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei286 – 2861UniRule annotation
Active sitei320 – 3201UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBANT592021:GJAQ-353-MONOMER.
UniPathwayiUPA00261; UER00374.

Names & Taxonomyi

Protein namesi
Recommended name:
1-pyrroline-5-carboxylate dehydrogenaseUniRule annotation (EC:1.2.1.88UniRule annotation)
Short name:
P5C dehydrogenaseUniRule annotation
Alternative name(s):
L-glutamate gamma-semialdehyde dehydrogenaseUniRule annotation
Gene namesi
Name:rocAUniRule annotation
Ordered Locus Names:BAA_0363
OrganismiBacillus anthracis (strain A0248)
Taxonomic identifieri592021 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5155151-pyrroline-5-carboxylate dehydrogenasePRO_1000148095Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliC3PBP4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family. RocA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271511.
KOiK00294.
OMAiQPYKHEP.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00733. RocA.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR005932. RocA.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01237. D1pyr5carbox2. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3PBP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVAYKHEPF TDFSVEANKL AFEEGLKKVE SYLGQDYPLI IGGEKITTED
60 70 80 90 100
KIVSVNPANK EELVGRVSKA SRELAEKAMQ VADETFQTWR KSKPEMRADI
110 120 130 140 150
LFRAAAIVRR RKHEFSAILV KEAGKPWNEA DADTAEAIDF MEYYGRQMLK
160 170 180 190 200
LKDGIPVESR PIEYNRFSYI PLGVGVIISP WNFPFAIMAG MTTAALVSGN
210 220 230 240 250
TVLLKPASTT PVVAAKFMEV LEEAGLPAGV VNFVPGNGSE VGDYLVDHPR
260 270 280 290 300
TRFISFTGSR DVGIRIYERA AKVNPGQIWL KRVIAEMGGK DTIVVDKEAD
310 320 330 340 350
LELAAKSIVA SAFGFSGQKC SACSRAVIHE DVYDHVLNRA VELTKELTVA
360 370 380 390 400
NPAVLGTNMG PVNDQAAFDK VMSYVAIGKE EGRILAGGEG DDSKGWFIQP
410 420 430 440 450
TIVADVAEDA RLMKEEIFGP VVAFCKAKDF DHALAIANNT EYGLTGAVIS
460 470 480 490 500
NNRDHIEKAR EDFHVGNLYF NRGCTGAIVG YQPFGGFNMS GTDSKAGGPD
510
YLALHMQAKT TSETL
Length:515
Mass (Da):56,225
Last modified:June 16, 2009 - v1
Checksum:i13A0909998818332
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001598 Genomic DNA. Translation: ACQ48277.1.
RefSeqiWP_000259550.1. NC_012659.1.
YP_002864926.1. NC_012659.1.

Genome annotation databases

EnsemblBacteriaiACQ48277; ACQ48277; BAA_0363.
KEGGibai:BAA_0363.
PATRICi18766467. VBIBacAnt132916_0608.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001598 Genomic DNA. Translation: ACQ48277.1.
RefSeqiWP_000259550.1. NC_012659.1.
YP_002864926.1. NC_012659.1.

3D structure databases

ProteinModelPortaliC3PBP4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACQ48277; ACQ48277; BAA_0363.
KEGGibai:BAA_0363.
PATRICi18766467. VBIBacAnt132916_0608.

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271511.
KOiK00294.
OMAiQPYKHEP.
OrthoDBiEOG6BS8QW.

Enzyme and pathway databases

UniPathwayiUPA00261; UER00374.
BioCyciBANT592021:GJAQ-353-MONOMER.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00733. RocA.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR005932. RocA.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01237. D1pyr5carbox2. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Bacillus anthracis A0248."
    Dodson R.J., Munk A.C., Bruce D., Detter C., Tapia R., Sutton G., Sims D., Brettin T.
    Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A0248.

Entry informationi

Entry nameiROCA_BACAA
AccessioniPrimary (citable) accession number: C3PBP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: June 24, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.