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Protein

1-pyrroline-5-carboxylate dehydrogenase

Gene

rocA

Organism
Bacillus anthracis (strain A0248)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate 5-semialdehyde + NAD+ + H2O = L-glutamate + NADH.UniRule annotation

Pathwayi: L-proline degradation into L-glutamate

This protein is involved in step 2 of the subpathway that synthesizes L-glutamate from L-proline.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 1-pyrroline-5-carboxylate dehydrogenase (rocA)
This subpathway is part of the pathway L-proline degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate from L-proline, the pathway L-proline degradation into L-glutamate and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei286UniRule annotation1
Active sitei320UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00261; UER00374

Names & Taxonomyi

Protein namesi
Recommended name:
1-pyrroline-5-carboxylate dehydrogenaseUniRule annotation (EC:1.2.1.88UniRule annotation)
Short name:
P5C dehydrogenaseUniRule annotation
Alternative name(s):
L-glutamate gamma-semialdehyde dehydrogenaseUniRule annotation
Gene namesi
Name:rocAUniRule annotation
Ordered Locus Names:BAA_0363
OrganismiBacillus anthracis (strain A0248)
Taxonomic identifieri592021 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001480951 – 5151-pyrroline-5-carboxylate dehydrogenaseAdd BLAST515

Proteomic databases

PRIDEiC3PBP4

Structurei

3D structure databases

ProteinModelPortaliC3PBP4
SMRiC3PBP4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family. RocA subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000271511
KOiK00294
OMAiNKQLTGA

Family and domain databases

CDDicd07124 ALDH_PutA-P5CDH-RocA, 1 hit
Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
HAMAPiMF_00733 RocA, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR005932 RocA
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR01237 D1pyr5carbox2, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

C3PBP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVAYKHEPF TDFSVEANKL AFEEGLKKVE SYLGQDYPLI IGGEKITTED
60 70 80 90 100
KIVSVNPANK EELVGRVSKA SRELAEKAMQ VADETFQTWR KSKPEMRADI
110 120 130 140 150
LFRAAAIVRR RKHEFSAILV KEAGKPWNEA DADTAEAIDF MEYYGRQMLK
160 170 180 190 200
LKDGIPVESR PIEYNRFSYI PLGVGVIISP WNFPFAIMAG MTTAALVSGN
210 220 230 240 250
TVLLKPASTT PVVAAKFMEV LEEAGLPAGV VNFVPGNGSE VGDYLVDHPR
260 270 280 290 300
TRFISFTGSR DVGIRIYERA AKVNPGQIWL KRVIAEMGGK DTIVVDKEAD
310 320 330 340 350
LELAAKSIVA SAFGFSGQKC SACSRAVIHE DVYDHVLNRA VELTKELTVA
360 370 380 390 400
NPAVLGTNMG PVNDQAAFDK VMSYVAIGKE EGRILAGGEG DDSKGWFIQP
410 420 430 440 450
TIVADVAEDA RLMKEEIFGP VVAFCKAKDF DHALAIANNT EYGLTGAVIS
460 470 480 490 500
NNRDHIEKAR EDFHVGNLYF NRGCTGAIVG YQPFGGFNMS GTDSKAGGPD
510
YLALHMQAKT TSETL
Length:515
Mass (Da):56,225
Last modified:June 16, 2009 - v1
Checksum:i13A0909998818332
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001598 Genomic DNA Translation: ACQ48277.1
RefSeqiWP_000259550.1, NC_012659.1

Genome annotation databases

EnsemblBacteriaiACQ48277; ACQ48277; BAA_0363
KEGGibai:BAA_0363

Similar proteinsi

Entry informationi

Entry nameiROCA_BACAA
AccessioniPrimary (citable) accession number: C3PBP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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