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C3PBP4

- ROCA_BACAA

UniProt

C3PBP4 - ROCA_BACAA

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Protein

1-pyrroline-5-carboxylate dehydrogenase

Gene

rocA

Organism
Bacillus anthracis (strain A0248)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate 5-semialdehyde + NAD+ + H2O = L-glutamate + NADH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei286 – 2861UniRule annotation
Active sitei320 – 3201UniRule annotation

GO - Molecular functioni

  1. 1-pyrroline-5-carboxylate dehydrogenase activity Source: UniProtKB-HAMAP
  2. oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Source: InterPro

GO - Biological processi

  1. glutamate biosynthetic process Source: UniProtKB-HAMAP
  2. proline catabolic process to glutamate Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBANT592021:GJAQ-353-MONOMER.
UniPathwayiUPA00261; UER00374.

Names & Taxonomyi

Protein namesi
Recommended name:
1-pyrroline-5-carboxylate dehydrogenaseUniRule annotation (EC:1.2.1.88UniRule annotation)
Short name:
P5C dehydrogenaseUniRule annotation
Alternative name(s):
L-glutamate gamma-semialdehyde dehydrogenaseUniRule annotation
Gene namesi
Name:rocAUniRule annotation
Ordered Locus Names:BAA_0363
OrganismiBacillus anthracis (strain A0248)
Taxonomic identifieri592021 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000002335: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5155151-pyrroline-5-carboxylate dehydrogenasePRO_1000148095Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi592021.BAA_0363.

Structurei

3D structure databases

ProteinModelPortaliC3PBP4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family. RocA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271511.
KOiK00294.
OMAiKWLKRVI.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00733. RocA.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR005932. RocA.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01237. D1pyr5carbox2. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3PBP4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVVAYKHEPF TDFSVEANKL AFEEGLKKVE SYLGQDYPLI IGGEKITTED
60 70 80 90 100
KIVSVNPANK EELVGRVSKA SRELAEKAMQ VADETFQTWR KSKPEMRADI
110 120 130 140 150
LFRAAAIVRR RKHEFSAILV KEAGKPWNEA DADTAEAIDF MEYYGRQMLK
160 170 180 190 200
LKDGIPVESR PIEYNRFSYI PLGVGVIISP WNFPFAIMAG MTTAALVSGN
210 220 230 240 250
TVLLKPASTT PVVAAKFMEV LEEAGLPAGV VNFVPGNGSE VGDYLVDHPR
260 270 280 290 300
TRFISFTGSR DVGIRIYERA AKVNPGQIWL KRVIAEMGGK DTIVVDKEAD
310 320 330 340 350
LELAAKSIVA SAFGFSGQKC SACSRAVIHE DVYDHVLNRA VELTKELTVA
360 370 380 390 400
NPAVLGTNMG PVNDQAAFDK VMSYVAIGKE EGRILAGGEG DDSKGWFIQP
410 420 430 440 450
TIVADVAEDA RLMKEEIFGP VVAFCKAKDF DHALAIANNT EYGLTGAVIS
460 470 480 490 500
NNRDHIEKAR EDFHVGNLYF NRGCTGAIVG YQPFGGFNMS GTDSKAGGPD
510
YLALHMQAKT TSETL
Length:515
Mass (Da):56,225
Last modified:June 16, 2009 - v1
Checksum:i13A0909998818332
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001598 Genomic DNA. Translation: ACQ48277.1.
RefSeqiYP_002864926.1. NC_012659.1.

Genome annotation databases

EnsemblBacteriaiACQ48277; ACQ48277; BAA_0363.
GeneIDi7849111.
KEGGibai:BAA_0363.
PATRICi18766467. VBIBacAnt132916_0608.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001598 Genomic DNA. Translation: ACQ48277.1 .
RefSeqi YP_002864926.1. NC_012659.1.

3D structure databases

ProteinModelPortali C3PBP4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 592021.BAA_0363.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ48277 ; ACQ48277 ; BAA_0363 .
GeneIDi 7849111.
KEGGi bai:BAA_0363.
PATRICi 18766467. VBIBacAnt132916_0608.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271511.
KOi K00294.
OMAi KWLKRVI.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

UniPathwayi UPA00261 ; UER00374 .
BioCyci BANT592021:GJAQ-353-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPi MF_00733. RocA.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR005932. RocA.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR01237. D1pyr5carbox2. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Bacillus anthracis A0248."
    Dodson R.J., Munk A.C., Bruce D., Detter C., Tapia R., Sutton G., Sims D., Brettin T.
    Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A0248.

Entry informationi

Entry nameiROCA_BACAA
AccessioniPrimary (citable) accession number: C3PBP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: October 29, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3