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C3PBP4

- ROCA_BACAA

UniProt

C3PBP4 - ROCA_BACAA

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Protein

1-pyrroline-5-carboxylate dehydrogenase

Gene
rocA, BAA_0363
Organism
Bacillus anthracis (strain A0248)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate 5-semialdehyde + NAD+ + H2O = L-glutamate + NADH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei286 – 2861 By similarity
Active sitei320 – 3201 By similarity

GO - Molecular functioni

  1. 1-pyrroline-5-carboxylate dehydrogenase activity Source: UniProtKB-HAMAP
  2. oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Source: InterPro

GO - Biological processi

  1. glutamate biosynthetic process Source: UniProtKB-HAMAP
  2. proline biosynthetic process Source: InterPro
  3. proline catabolic process to glutamate Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBANT592021:GJAQ-353-MONOMER.
UniPathwayiUPA00261; UER00374.

Names & Taxonomyi

Protein namesi
Recommended name:
1-pyrroline-5-carboxylate dehydrogenase (EC:1.2.1.88)
Short name:
P5C dehydrogenase
Alternative name(s):
L-glutamate gamma-semialdehyde dehydrogenase
Gene namesi
Name:rocA
Ordered Locus Names:BAA_0363
OrganismiBacillus anthracis (strain A0248)
Taxonomic identifieri592021 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000002335: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5155151-pyrroline-5-carboxylate dehydrogenaseUniRule annotationPRO_1000148095Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi592021.BAA_0363.

Structurei

3D structure databases

ProteinModelPortaliC3PBP4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271511.
KOiK00294.
OMAiKWLKRVI.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00733. RocA.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR005932. RocA.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01237. D1pyr5carbox2. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3PBP4-1 [UniParc]FASTAAdd to Basket

« Hide

MVVAYKHEPF TDFSVEANKL AFEEGLKKVE SYLGQDYPLI IGGEKITTED    50
KIVSVNPANK EELVGRVSKA SRELAEKAMQ VADETFQTWR KSKPEMRADI 100
LFRAAAIVRR RKHEFSAILV KEAGKPWNEA DADTAEAIDF MEYYGRQMLK 150
LKDGIPVESR PIEYNRFSYI PLGVGVIISP WNFPFAIMAG MTTAALVSGN 200
TVLLKPASTT PVVAAKFMEV LEEAGLPAGV VNFVPGNGSE VGDYLVDHPR 250
TRFISFTGSR DVGIRIYERA AKVNPGQIWL KRVIAEMGGK DTIVVDKEAD 300
LELAAKSIVA SAFGFSGQKC SACSRAVIHE DVYDHVLNRA VELTKELTVA 350
NPAVLGTNMG PVNDQAAFDK VMSYVAIGKE EGRILAGGEG DDSKGWFIQP 400
TIVADVAEDA RLMKEEIFGP VVAFCKAKDF DHALAIANNT EYGLTGAVIS 450
NNRDHIEKAR EDFHVGNLYF NRGCTGAIVG YQPFGGFNMS GTDSKAGGPD 500
YLALHMQAKT TSETL 515
Length:515
Mass (Da):56,225
Last modified:June 16, 2009 - v1
Checksum:i13A0909998818332
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001598 Genomic DNA. Translation: ACQ48277.1.
RefSeqiYP_002864926.1. NC_012659.1.

Genome annotation databases

EnsemblBacteriaiACQ48277; ACQ48277; BAA_0363.
GeneIDi7849111.
KEGGibai:BAA_0363.
PATRICi18766467. VBIBacAnt132916_0608.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001598 Genomic DNA. Translation: ACQ48277.1 .
RefSeqi YP_002864926.1. NC_012659.1.

3D structure databases

ProteinModelPortali C3PBP4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 592021.BAA_0363.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ48277 ; ACQ48277 ; BAA_0363 .
GeneIDi 7849111.
KEGGi bai:BAA_0363.
PATRICi 18766467. VBIBacAnt132916_0608.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271511.
KOi K00294.
OMAi KWLKRVI.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

UniPathwayi UPA00261 ; UER00374 .
BioCyci BANT592021:GJAQ-353-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPi MF_00733. RocA.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR005932. RocA.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR01237. D1pyr5carbox2. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Bacillus anthracis A0248."
    Dodson R.J., Munk A.C., Bruce D., Detter C., Tapia R., Sutton G., Sims D., Brettin T.
    Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A0248.

Entry informationi

Entry nameiROCA_BACAA
AccessioniPrimary (citable) accession number: C3PBP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: September 3, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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