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C3PBP4

- ROCA_BACAA

UniProt

C3PBP4 - ROCA_BACAA

Protein

1-pyrroline-5-carboxylate dehydrogenase

Gene

rocA

Organism
Bacillus anthracis (strain A0248)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamate 5-semialdehyde + NAD+ + H2O = L-glutamate + NADH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei286 – 2861UniRule annotation
    Active sitei320 – 3201UniRule annotation

    GO - Molecular functioni

    1. 1-pyrroline-5-carboxylate dehydrogenase activity Source: UniProtKB-HAMAP
    2. oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Source: InterPro

    GO - Biological processi

    1. glutamate biosynthetic process Source: UniProtKB-HAMAP
    2. proline biosynthetic process Source: InterPro
    3. proline catabolic process to glutamate Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciBANT592021:GJAQ-353-MONOMER.
    UniPathwayiUPA00261; UER00374.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-pyrroline-5-carboxylate dehydrogenaseUniRule annotation (EC:1.2.1.88UniRule annotation)
    Short name:
    P5C dehydrogenaseUniRule annotation
    Alternative name(s):
    L-glutamate gamma-semialdehyde dehydrogenaseUniRule annotation
    Gene namesi
    Name:rocAUniRule annotation
    Ordered Locus Names:BAA_0363
    OrganismiBacillus anthracis (strain A0248)
    Taxonomic identifieri592021 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000002335: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5155151-pyrroline-5-carboxylate dehydrogenasePRO_1000148095Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi592021.BAA_0363.

    Structurei

    3D structure databases

    ProteinModelPortaliC3PBP4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family. RocA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271511.
    KOiK00294.
    OMAiKWLKRVI.
    OrthoDBiEOG6BS8QW.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPiMF_00733. RocA.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR005932. RocA.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR01237. D1pyr5carbox2. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C3PBP4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVVAYKHEPF TDFSVEANKL AFEEGLKKVE SYLGQDYPLI IGGEKITTED    50
    KIVSVNPANK EELVGRVSKA SRELAEKAMQ VADETFQTWR KSKPEMRADI 100
    LFRAAAIVRR RKHEFSAILV KEAGKPWNEA DADTAEAIDF MEYYGRQMLK 150
    LKDGIPVESR PIEYNRFSYI PLGVGVIISP WNFPFAIMAG MTTAALVSGN 200
    TVLLKPASTT PVVAAKFMEV LEEAGLPAGV VNFVPGNGSE VGDYLVDHPR 250
    TRFISFTGSR DVGIRIYERA AKVNPGQIWL KRVIAEMGGK DTIVVDKEAD 300
    LELAAKSIVA SAFGFSGQKC SACSRAVIHE DVYDHVLNRA VELTKELTVA 350
    NPAVLGTNMG PVNDQAAFDK VMSYVAIGKE EGRILAGGEG DDSKGWFIQP 400
    TIVADVAEDA RLMKEEIFGP VVAFCKAKDF DHALAIANNT EYGLTGAVIS 450
    NNRDHIEKAR EDFHVGNLYF NRGCTGAIVG YQPFGGFNMS GTDSKAGGPD 500
    YLALHMQAKT TSETL 515
    Length:515
    Mass (Da):56,225
    Last modified:June 16, 2009 - v1
    Checksum:i13A0909998818332
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001598 Genomic DNA. Translation: ACQ48277.1.
    RefSeqiYP_002864926.1. NC_012659.1.

    Genome annotation databases

    EnsemblBacteriaiACQ48277; ACQ48277; BAA_0363.
    GeneIDi7849111.
    KEGGibai:BAA_0363.
    PATRICi18766467. VBIBacAnt132916_0608.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001598 Genomic DNA. Translation: ACQ48277.1 .
    RefSeqi YP_002864926.1. NC_012659.1.

    3D structure databases

    ProteinModelPortali C3PBP4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 592021.BAA_0363.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACQ48277 ; ACQ48277 ; BAA_0363 .
    GeneIDi 7849111.
    KEGGi bai:BAA_0363.
    PATRICi 18766467. VBIBacAnt132916_0608.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271511.
    KOi K00294.
    OMAi KWLKRVI.
    OrthoDBi EOG6BS8QW.

    Enzyme and pathway databases

    UniPathwayi UPA00261 ; UER00374 .
    BioCyci BANT592021:GJAQ-353-MONOMER.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPi MF_00733. RocA.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR005932. RocA.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR01237. D1pyr5carbox2. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Bacillus anthracis A0248."
      Dodson R.J., Munk A.C., Bruce D., Detter C., Tapia R., Sutton G., Sims D., Brettin T.
      Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: A0248.

    Entry informationi

    Entry nameiROCA_BACAA
    AccessioniPrimary (citable) accession number: C3PBP4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3