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C3PBP4 (ROCA_BACAA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
1-pyrroline-5-carboxylate dehydrogenase

Short name=P5C dehydrogenase
EC=1.2.1.88
Alternative name(s):
L-glutamate gamma-semialdehyde dehydrogenase
Gene names
Name:rocA
Ordered Locus Names:BAA_0363
OrganismBacillus anthracis (strain A0248) [Complete proteome] [HAMAP]
Taxonomic identifier592021 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length515 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-glutamate 5-semialdehyde + NAD+ + H2O = L-glutamate + NADH. HAMAP-Rule MF_00733

Pathway

Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2. HAMAP-Rule MF_00733

Sequence similarities

Belongs to the aldehyde dehydrogenase family. RocA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 5155151-pyrroline-5-carboxylate dehydrogenase HAMAP-Rule MF_00733
PRO_1000148095

Sites

Active site2861 By similarity
Active site3201 By similarity

Sequences

Sequence LengthMass (Da)Tools
C3PBP4 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: 13A0909998818332

FASTA51556,225
        10         20         30         40         50         60 
MVVAYKHEPF TDFSVEANKL AFEEGLKKVE SYLGQDYPLI IGGEKITTED KIVSVNPANK 

        70         80         90        100        110        120 
EELVGRVSKA SRELAEKAMQ VADETFQTWR KSKPEMRADI LFRAAAIVRR RKHEFSAILV 

       130        140        150        160        170        180 
KEAGKPWNEA DADTAEAIDF MEYYGRQMLK LKDGIPVESR PIEYNRFSYI PLGVGVIISP 

       190        200        210        220        230        240 
WNFPFAIMAG MTTAALVSGN TVLLKPASTT PVVAAKFMEV LEEAGLPAGV VNFVPGNGSE 

       250        260        270        280        290        300 
VGDYLVDHPR TRFISFTGSR DVGIRIYERA AKVNPGQIWL KRVIAEMGGK DTIVVDKEAD 

       310        320        330        340        350        360 
LELAAKSIVA SAFGFSGQKC SACSRAVIHE DVYDHVLNRA VELTKELTVA NPAVLGTNMG 

       370        380        390        400        410        420 
PVNDQAAFDK VMSYVAIGKE EGRILAGGEG DDSKGWFIQP TIVADVAEDA RLMKEEIFGP 

       430        440        450        460        470        480 
VVAFCKAKDF DHALAIANNT EYGLTGAVIS NNRDHIEKAR EDFHVGNLYF NRGCTGAIVG 

       490        500        510 
YQPFGGFNMS GTDSKAGGPD YLALHMQAKT TSETL 

« Hide

References

[1]"Genome sequence of Bacillus anthracis A0248."
Dodson R.J., Munk A.C., Bruce D., Detter C., Tapia R., Sutton G., Sims D., Brettin T.
Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: A0248.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001598 Genomic DNA. Translation: ACQ48277.1.
RefSeqYP_002864926.1. NC_012659.1.

3D structure databases

ProteinModelPortalC3PBP4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING592021.BAA_0363.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACQ48277; ACQ48277; BAA_0363.
GeneID7849111.
KEGGbai:BAA_0363.
PATRIC18766467. VBIBacAnt132916_0608.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271511.
KOK00294.
OMARAREDFH.
OrthoDBEOG6BS8QW.
ProtClustDBPRK03137.

Enzyme and pathway databases

BioCycBANT592021:GJAQ-353-MONOMER.
UniPathwayUPA00261; UER00374.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPMF_00733. RocA.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR005932. Delta1-pyrroline-5-COlate_DH-2.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR01237. D1pyr5carbox2. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameROCA_BACAA
AccessionPrimary (citable) accession number: C3PBP4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: February 19, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways