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C3PBM5

- C3PBM5_BACAA

UniProt

C3PBM5 - C3PBM5_BACAA

Protein
Submitted name:

Phosphoribosylaminoimidazole carboxylase, ATPase subunit

Gene

purK

Organism
Bacillus anthracis (strain A0248)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei76 – 761ATP; via carbonyl oxygenImported
    Metal bindingi104 – 1041Magnesium 1; via carbonyl oxygenImported
    Binding sitei107 – 1071ADPImported
    Binding sitei107 – 1071ATPImported
    Metal bindingi110 – 1101Magnesium 1Imported
    Binding sitei147 – 1471ADPImported
    Binding sitei147 – 1471ATPImported
    Binding sitei190 – 1901ADPImported
    Binding sitei190 – 1901ATPImported
    Metal bindingi255 – 2551CalciumImported
    Metal bindingi255 – 2551Magnesium 2Imported
    Binding sitei255 – 2551ATPImported
    Metal bindingi268 – 2681CalciumImported
    Metal bindingi268 – 2681Magnesium 2Imported
    Metal bindingi269 – 2691Magnesium 1; via carbonyl oxygenImported
    Binding sitei340 – 3401ATPImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi153 – 1586ATPImported
    Nucleotide bindingi154 – 1585ADPImported
    Nucleotide bindingi182 – 1854ADPImported
    Nucleotide bindingi182 – 1854ATPImported
    Nucleotide bindingi213 – 2164ADPImported
    Nucleotide bindingi213 – 2164ATPImported
    Nucleotide bindingi255 – 2573ADPImported
    Nucleotide bindingi267 – 2682ADPImported
    Nucleotide bindingi267 – 2682ATPImported
    Nucleotide bindingi272 – 2754ATPImported
    Nucleotide bindingi347 – 3482ATPImported

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cofactor binding Source: InterPro
    3. metal ion binding Source: UniProtKB-KW
    4. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro
    5. phosphoribosylaminoimidazole carboxylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    LyaseImported

    Keywords - Biological processi

    Purine biosynthesisSAAS annotation

    Keywords - Ligandi

    ATP-bindingSAAS annotationImported, CalciumImported, MagnesiumImported, Metal-bindingImported, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBANT592021:GJAQ-334-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Phosphoribosylaminoimidazole carboxylase, ATPase subunitImported (EC:4.1.1.21Imported)
    Gene namesi
    Name:purKImported
    Ordered Locus Names:BAA_0344Imported
    OrganismiBacillus anthracis (strain A0248)Imported
    Taxonomic identifieri592021 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000002335: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi592021.BAA_0344.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3Q2OX-ray1.96A/B1-383[»]
    3QFFX-ray1.96A/B1-383[»]
    3R5HX-ray2.20A/B1-383[»]
    3V4SX-ray2.02A/B1-378[»]
    4DLKX-ray2.02A/B1-380[»]
    ProteinModelPortaliC3PBM5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains ATP-grasp domain.SAAS annotation

    Phylogenomic databases

    eggNOGiCOG0026.
    HOGENOMiHOG000034029.
    KOiK01589.
    OMAiDCILEGW.
    OrthoDBiEOG6QZMX7.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    InterProiIPR005875. AIR_COase_ATPase-su.
    IPR011761. ATP-grasp.
    IPR003135. ATP-grasp_carboxylate-amine.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR006140. D-isomer_DH_NAD-bd.
    IPR016185. PreATP-grasp_dom.
    IPR011054. Rudment_hybrid_motif.
    [Graphical view]
    PfamiPF02826. 2-Hacid_dh_C. 1 hit.
    PF02222. ATP-grasp. 1 hit.
    [Graphical view]
    SUPFAMiSSF51246. SSF51246. 1 hit.
    SSF52440. SSF52440. 1 hit.
    TIGRFAMsiTIGR01161. purK. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C3PBM5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRIILPGKT IGIIGGGQLG RMMALAAKEM GYKIAVLDPT KNSPCAQVAD    50
    IEIVASYDDL KAIQHLAEIS DVVTYEFENI DYRCLQWLEK HAYLPQGSQL 100
    LSKTQNRFTE KNAIEKAGLP VATYRLVQNQ EQLTEAIAEL SYPSVLKTTT 150
    GGYDGKGQVV LRSEADVDEA RKLANAAECI LEKWVPFEKE VSVIVIRSVS 200
    GETKVFPVAE NIHVNNILHE SIVPARITEE LSQKAIAYAK VLADELELVG 250
    TLAVEMFATA DGEIYINELA PRPHNSGHYT QDACETSQFG QHIRAICNLP 300
    LGETNLLKPV VMVNILGEHI EGVLRQVNRL TGCYLHLYGK EEAKAQRKMG 350
    HVNILNDNIE VALEKAKSLH IWDHQEQLLE GKR 383
    Length:383
    Mass (Da):42,517
    Last modified:June 16, 2009 - v1
    Checksum:iBE0E5E1A56F88287
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001598 Genomic DNA. Translation: ACQ48995.1.
    RefSeqiYP_002864907.1. NC_012659.1.

    Genome annotation databases

    EnsemblBacteriaiACQ48995; ACQ48995; BAA_0344.
    GeneIDi7848383.
    KEGGibai:BAA_0344.
    PATRICi18766429. VBIBacAnt132916_0589.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001598 Genomic DNA. Translation: ACQ48995.1 .
    RefSeqi YP_002864907.1. NC_012659.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3Q2O X-ray 1.96 A/B 1-383 [» ]
    3QFF X-ray 1.96 A/B 1-383 [» ]
    3R5H X-ray 2.20 A/B 1-383 [» ]
    3V4S X-ray 2.02 A/B 1-378 [» ]
    4DLK X-ray 2.02 A/B 1-380 [» ]
    ProteinModelPortali C3PBM5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 592021.BAA_0344.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACQ48995 ; ACQ48995 ; BAA_0344 .
    GeneIDi 7848383.
    KEGGi bai:BAA_0344.
    PATRICi 18766429. VBIBacAnt132916_0589.

    Phylogenomic databases

    eggNOGi COG0026.
    HOGENOMi HOG000034029.
    KOi K01589.
    OMAi DCILEGW.
    OrthoDBi EOG6QZMX7.

    Enzyme and pathway databases

    BioCyci BANT592021:GJAQ-334-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    InterProi IPR005875. AIR_COase_ATPase-su.
    IPR011761. ATP-grasp.
    IPR003135. ATP-grasp_carboxylate-amine.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR006140. D-isomer_DH_NAD-bd.
    IPR016185. PreATP-grasp_dom.
    IPR011054. Rudment_hybrid_motif.
    [Graphical view ]
    Pfami PF02826. 2-Hacid_dh_C. 1 hit.
    PF02222. ATP-grasp. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51246. SSF51246. 1 hit.
    SSF52440. SSF52440. 1 hit.
    TIGRFAMsi TIGR01161. purK. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Bacillus anthracis A0248."
      Dodson R.J., Munk A.C., Bruce D., Detter C., Tapia R., Sutton G., Sims D., Brettin T.
      Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: A0248Imported.
    2. "Structure of N5-carboxyaminoimidazole ribonucleotide synthase (PurK) from Bacillus anthracis."
      Tuntland M.L., Johnson M.E., Fung L.W., Santarsiero B.D.
      Acta Crystallogr. D 67:870-874(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.
    3. "Crystal Structure of purK: N5-carboxyaminoimidazole ribonucleotide synthetase."
      Fung L.W., Tuntland M.L., Santarsiero B.D., Johnson M.E.
      Submitted (JAN-2011) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) IN COMPLEX WITH ADP.
    4. "Crystal Structure of purK: N5-carboxyaminoimidazole ribonucleotide synthetase."
      Fung L.W., Tuntland M.L., Santarsiero B.D., Johnson M.E.
      Submitted (MAR-2011) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) IN COMPLEX WITH ADP.
    5. "Crystal Structure of ADP-ATP complex of purK: N5-carboxyaminoimidazole ribonucleotide synthetase."
      Fung L.W., Tuntland M.L., Santarsiero B.D., Johnson M.E.
      Submitted (DEC-2011) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.02 ANGSTROMS) OF 1-378 IN COMPLEX WITH ADP; ATP AND MAGNESIUM.
    6. "Crystal Structure of purK: N5-carboxyaminoimidazole ribonucleotide synthetase."
      Fung L.W., Tuntland M.L., Santarsiero B.D., Johnson M.E.
      Submitted (FEB-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.02 ANGSTROMS) OF 1-380 IN COMPLEX WITH ATP AND CALCIUM.

    Entry informationi

    Entry nameiC3PBM5_BACAA
    AccessioniPrimary (citable) accession number: C3PBM5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 16, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3