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C3PBM5 (C3PBM5_BACAA) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
EC=4.1.1.21 EMBL ACQ48995.1
Gene names
Name:purK EMBL ACQ48995.1
Ordered Locus Names:BAA_0344 EMBL ACQ48995.1
OrganismBacillus anthracis (strain A0248) [Complete proteome] [HAMAP] EMBL ACQ48995.1
Taxonomic identifier592021 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length383 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains ATP-grasp domain. SAAS SAAS003135

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding153 – 1586ATP
Nucleotide binding154 – 1585ADP PDB 3QFF PDB 3R5H
Nucleotide binding182 – 1854ADP PDB 3QFF PDB 3R5H
Nucleotide binding182 – 1854ATP
Nucleotide binding213 – 2164ADP PDB 3QFF PDB 3R5H
Nucleotide binding213 – 2164ATP
Nucleotide binding255 – 2573ADP PDB 3QFF
Nucleotide binding267 – 2682ADP PDB 3QFF PDB 3R5H
Nucleotide binding267 – 2682ATP
Nucleotide binding272 – 2754ATP PDB 4DLK
Nucleotide binding347 – 3482ATP PDB 4DLK
Region46 – 494Phosphate binding PDB 4DLK

Sites

Metal binding1041Magnesium 1; via carbonyl oxygen PDB 3Q2O
Metal binding1101Magnesium 1 PDB 3Q2O
Metal binding2551Calcium PDB 4DLK
Metal binding2551Magnesium 2
Metal binding2681Calcium PDB 4DLK
Metal binding2681Magnesium 2
Metal binding2691Magnesium 1; via carbonyl oxygen PDB 3Q2O
Binding site761ATP; via carbonyl oxygen PDB 4DLK
Binding site1071ADP PDB 3QFF PDB 3R5H
Binding site1071ATP
Binding site1471ADP PDB 3QFF PDB 3R5H
Binding site1471ATP
Binding site1901ADP PDB 3QFF PDB 3R5H
Binding site1901ATP
Binding site2551ATP
Binding site3401ATP PDB 4DLK

Sequences

Sequence LengthMass (Da)Tools
C3PBM5 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: BE0E5E1A56F88287

FASTA38342,517
        10         20         30         40         50         60 
MTRIILPGKT IGIIGGGQLG RMMALAAKEM GYKIAVLDPT KNSPCAQVAD IEIVASYDDL 

        70         80         90        100        110        120 
KAIQHLAEIS DVVTYEFENI DYRCLQWLEK HAYLPQGSQL LSKTQNRFTE KNAIEKAGLP 

       130        140        150        160        170        180 
VATYRLVQNQ EQLTEAIAEL SYPSVLKTTT GGYDGKGQVV LRSEADVDEA RKLANAAECI 

       190        200        210        220        230        240 
LEKWVPFEKE VSVIVIRSVS GETKVFPVAE NIHVNNILHE SIVPARITEE LSQKAIAYAK 

       250        260        270        280        290        300 
VLADELELVG TLAVEMFATA DGEIYINELA PRPHNSGHYT QDACETSQFG QHIRAICNLP 

       310        320        330        340        350        360 
LGETNLLKPV VMVNILGEHI EGVLRQVNRL TGCYLHLYGK EEAKAQRKMG HVNILNDNIE 

       370        380 
VALEKAKSLH IWDHQEQLLE GKR 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of Bacillus anthracis A0248."
Dodson R.J., Munk A.C., Bruce D., Detter C., Tapia R., Sutton G., Sims D., Brettin T.
Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: A0248 EMBL ACQ48995.1.
[2]"Structure of N5-carboxyaminoimidazole ribonucleotide synthase (PurK) from Bacillus anthracis."
Tuntland M.L., Johnson M.E., Fung L.W., Santarsiero B.D.
Acta Crystallogr. D 67:870-874(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.
[3]"Crystal Structure of purK: N5-carboxyaminoimidazole ribonucleotide synthetase."
Fung L.W., Tuntland M.L., Santarsiero B.D., Johnson M.E.
Submitted (JAN-2011) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) IN COMPLEX WITH ADP.
[4]"Crystal Structure of purK: N5-carboxyaminoimidazole ribonucleotide synthetase."
Fung L.W., Tuntland M.L., Santarsiero B.D., Johnson M.E.
Submitted (MAR-2011) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) IN COMPLEX WITH ADP.
[5]"Crystal Structure of ADP-ATP complex of purK: N5-carboxyaminoimidazole ribonucleotide synthetase."
Fung L.W., Tuntland M.L., Santarsiero B.D., Johnson M.E.
Submitted (DEC-2011) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.02 ANGSTROMS) OF 1-378 IN COMPLEX WITH ADP; ATP AND MAGNESIUM.
[6]"Crystal Structure of purK: N5-carboxyaminoimidazole ribonucleotide synthetase."
Fung L.W., Tuntland M.L., Santarsiero B.D., Johnson M.E.
Submitted (FEB-2012) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.02 ANGSTROMS) OF 1-380 IN COMPLEX WITH ATP; CALCIUM AND PHOSPHATE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001598 Genomic DNA. Translation: ACQ48995.1.
RefSeqYP_002864907.1. NC_012659.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3Q2OX-ray1.96A/B1-383[»]
3QFFX-ray1.96A/B1-383[»]
3R5HX-ray2.20A/B1-383[»]
3V4SX-ray2.02A/B1-378[»]
4DLKX-ray2.02A/B1-380[»]
ProteinModelPortalC3PBM5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING592021.BAA_0344.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACQ48995; ACQ48995; BAA_0344.
GeneID7848383.
KEGGbai:BAA_0344.
PATRIC18766429. VBIBacAnt132916_0589.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0026.
HOGENOMHOG000034029.
KOK01589.
OMANSGHYTL.
OrthoDBEOG6QZMX7.
ProtClustDBPRK06019.

Enzyme and pathway databases

BioCycBANT592021:GJAQ-334-MONOMER.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProIPR005875. AIR_COase_ATPase-su.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR006140. D-isomer_2_OHA_DH_NAD-bd.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF02826. 2-Hacid_dh_C. 1 hit.
PF02222. ATP-grasp. 1 hit.
[Graphical view]
SUPFAMSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01161. purK. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC3PBM5_BACAA
AccessionPrimary (citable) accession number: C3PBM5
Entry history
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: February 19, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)