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C3PBM5

- C3PBM5_BACAA

UniProt

C3PBM5 - C3PBM5_BACAA

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Protein
Submitted name: Phosphoribosylaminoimidazole carboxylase, ATPase subunit
Gene
purK, BAA_0344
Organism
Bacillus anthracis (strain A0248)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei76 – 761ATP; via carbonyl oxygenImported
Metal bindingi104 – 1041Magnesium 1; via carbonyl oxygenImported
Binding sitei107 – 1071ADPImported
Binding sitei107 – 1071ATP
Metal bindingi110 – 1101Magnesium 1Imported
Binding sitei147 – 1471ADPImported
Binding sitei147 – 1471ATP
Binding sitei190 – 1901ADPImported
Binding sitei190 – 1901ATP
Metal bindingi255 – 2551CalciumImported
Metal bindingi255 – 2551Magnesium 2
Binding sitei255 – 2551ATP
Metal bindingi268 – 2681CalciumImported
Metal bindingi268 – 2681Magnesium 2
Metal bindingi269 – 2691Magnesium 1; via carbonyl oxygenImported
Binding sitei340 – 3401ATPImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi153 – 1586ATP
Nucleotide bindingi154 – 1585ADPImported
Nucleotide bindingi182 – 1854ADPImported
Nucleotide bindingi182 – 1854ATP
Nucleotide bindingi213 – 2164ADPImported
Nucleotide bindingi213 – 2164ATP
Nucleotide bindingi255 – 2573ADPImported
Nucleotide bindingi267 – 2682ADPImported
Nucleotide bindingi267 – 2682ATP
Nucleotide bindingi272 – 2754ATPImported
Nucleotide bindingi347 – 3482ATPImported

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cofactor binding Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
  4. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro
  5. phosphoribosylaminoimidazole carboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseImported

Keywords - Biological processi

Purine biosynthesisSAAS annotations

Keywords - Ligandi

ATP-bindingSAAS annotationsImported, CalciumImported, MagnesiumImported, Metal-bindingImported, Nucleotide-binding

Enzyme and pathway databases

BioCyciBANT592021:GJAQ-334-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphoribosylaminoimidazole carboxylase, ATPase subunitImported (EC:4.1.1.21Imported)
Gene namesi
Name:purKImported
Ordered Locus Names:BAA_0344Imported
OrganismiBacillus anthracis (strain A0248)Imported
Taxonomic identifieri592021 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000002335: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi592021.BAA_0344.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3Q2OX-ray1.96A/B1-383[»]
3QFFX-ray1.96A/B1-383[»]
3R5HX-ray2.20A/B1-383[»]
3V4SX-ray2.02A/B1-378[»]
4DLKX-ray2.02A/B1-380[»]
ProteinModelPortaliC3PBM5.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni46 – 494Phosphate bindingImported

Sequence similaritiesi

Contains ATP-grasp domain.SAAS annotations

Phylogenomic databases

eggNOGiCOG0026.
HOGENOMiHOG000034029.
KOiK01589.
OMAiDCILEGW.
OrthoDBiEOG6QZMX7.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR005875. AIR_COase_ATPase-su.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR006140. D-isomer_DH_NAD-bd.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamiPF02826. 2-Hacid_dh_C. 1 hit.
PF02222. ATP-grasp. 1 hit.
[Graphical view]
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01161. purK. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3PBM5-1 [UniParc]FASTAAdd to Basket

« Hide

MTRIILPGKT IGIIGGGQLG RMMALAAKEM GYKIAVLDPT KNSPCAQVAD    50
IEIVASYDDL KAIQHLAEIS DVVTYEFENI DYRCLQWLEK HAYLPQGSQL 100
LSKTQNRFTE KNAIEKAGLP VATYRLVQNQ EQLTEAIAEL SYPSVLKTTT 150
GGYDGKGQVV LRSEADVDEA RKLANAAECI LEKWVPFEKE VSVIVIRSVS 200
GETKVFPVAE NIHVNNILHE SIVPARITEE LSQKAIAYAK VLADELELVG 250
TLAVEMFATA DGEIYINELA PRPHNSGHYT QDACETSQFG QHIRAICNLP 300
LGETNLLKPV VMVNILGEHI EGVLRQVNRL TGCYLHLYGK EEAKAQRKMG 350
HVNILNDNIE VALEKAKSLH IWDHQEQLLE GKR 383
Length:383
Mass (Da):42,517
Last modified:June 16, 2009 - v1
Checksum:iBE0E5E1A56F88287
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001598 Genomic DNA. Translation: ACQ48995.1.
RefSeqiYP_002864907.1. NC_012659.1.

Genome annotation databases

EnsemblBacteriaiACQ48995; ACQ48995; BAA_0344.
GeneIDi7848383.
KEGGibai:BAA_0344.
PATRICi18766429. VBIBacAnt132916_0589.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001598 Genomic DNA. Translation: ACQ48995.1 .
RefSeqi YP_002864907.1. NC_012659.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3Q2O X-ray 1.96 A/B 1-383 [» ]
3QFF X-ray 1.96 A/B 1-383 [» ]
3R5H X-ray 2.20 A/B 1-383 [» ]
3V4S X-ray 2.02 A/B 1-378 [» ]
4DLK X-ray 2.02 A/B 1-380 [» ]
ProteinModelPortali C3PBM5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 592021.BAA_0344.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ48995 ; ACQ48995 ; BAA_0344 .
GeneIDi 7848383.
KEGGi bai:BAA_0344.
PATRICi 18766429. VBIBacAnt132916_0589.

Phylogenomic databases

eggNOGi COG0026.
HOGENOMi HOG000034029.
KOi K01589.
OMAi DCILEGW.
OrthoDBi EOG6QZMX7.

Enzyme and pathway databases

BioCyci BANT592021:GJAQ-334-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProi IPR005875. AIR_COase_ATPase-su.
IPR011761. ATP-grasp.
IPR003135. ATP-grasp_carboxylate-amine.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR006140. D-isomer_DH_NAD-bd.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
[Graphical view ]
Pfami PF02826. 2-Hacid_dh_C. 1 hit.
PF02222. ATP-grasp. 1 hit.
[Graphical view ]
SUPFAMi SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01161. purK. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of Bacillus anthracis A0248."
    Dodson R.J., Munk A.C., Bruce D., Detter C., Tapia R., Sutton G., Sims D., Brettin T.
    Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A0248Imported.
  2. "Structure of N5-carboxyaminoimidazole ribonucleotide synthase (PurK) from Bacillus anthracis."
    Tuntland M.L., Johnson M.E., Fung L.W., Santarsiero B.D.
    Acta Crystallogr. D 67:870-874(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.
  3. "Crystal Structure of purK: N5-carboxyaminoimidazole ribonucleotide synthetase."
    Fung L.W., Tuntland M.L., Santarsiero B.D., Johnson M.E.
    Submitted (JAN-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) IN COMPLEX WITH ADP.
  4. "Crystal Structure of purK: N5-carboxyaminoimidazole ribonucleotide synthetase."
    Fung L.W., Tuntland M.L., Santarsiero B.D., Johnson M.E.
    Submitted (MAR-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) IN COMPLEX WITH ADP.
  5. "Crystal Structure of ADP-ATP complex of purK: N5-carboxyaminoimidazole ribonucleotide synthetase."
    Fung L.W., Tuntland M.L., Santarsiero B.D., Johnson M.E.
    Submitted (DEC-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.02 ANGSTROMS) OF 1-378 IN COMPLEX WITH ADP; ATP AND MAGNESIUM.
  6. "Crystal Structure of purK: N5-carboxyaminoimidazole ribonucleotide synthetase."
    Fung L.W., Tuntland M.L., Santarsiero B.D., Johnson M.E.
    Submitted (FEB-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.02 ANGSTROMS) OF 1-380 IN COMPLEX WITH ATP; CALCIUM AND PHOSPHATE.

Entry informationi

Entry nameiC3PBM5_BACAA
AccessioniPrimary (citable) accession number: C3PBM5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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