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C3PBG1

- TRMB_BACAA

UniProt

C3PBG1 - TRMB_BACAA

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, BAA_4959
Organism
Bacillus anthracis (strain A0248)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441S-adenosyl-L-methionine By similarity
Binding sitei69 – 691S-adenosyl-L-methionine By similarity
Binding sitei96 – 961S-adenosyl-L-methionine By similarity
Active sitei118 – 1181 By similarity
Binding sitei118 – 1181S-adenosyl-L-methionine By similarity
Binding sitei122 – 1221Substrate By similarity
Binding sitei154 – 1541Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciBANT592021:GJAQ-4905-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:BAA_4959
OrganismiBacillus anthracis (strain A0248)
Taxonomic identifieri592021 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000002335: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_1000149642Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi592021.BAA_4959.

Structurei

3D structure databases

ProteinModelPortaliC3PBG1.
SMRiC3PBG1. Positions 11-213.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni191 – 1944Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000251689.
KOiK03439.
OMAiDNVMTEY.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3PBG1-1 [UniParc]FASTAAdd to Basket

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MRLRHKPYAM DRINEYSHIV IGNPEERAGN WKEVFGNEQP IHIEVGTGRG    50
RFMYDMAKAN PHINYIGIEK FTSVVVDALD KLIEEELPNL KLINKDAEDL 100
TVFFAKGEID RVYLNFSDPW PKKRHTKRRL TYKTFLRNYE EVLVEGGEIH 150
FKTDNQGLFE YSLMSMAEYG MLLTYLSLDL HNSDFEGNIM TEYEEKFSSK 200
GHRIYRVEAK YRTEPMQ 217
Length:217
Mass (Da):25,600
Last modified:June 16, 2009 - v1
Checksum:i3227646A0B193686
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001598 Genomic DNA. Translation: ACQ50325.1.
RefSeqiYP_002868977.1. NC_012659.1.

Genome annotation databases

EnsemblBacteriaiACQ50325; ACQ50325; BAA_4959.
GeneIDi7851430.
KEGGibai:BAA_4959.
PATRICi18775818. VBIBacAnt132916_5219.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001598 Genomic DNA. Translation: ACQ50325.1 .
RefSeqi YP_002868977.1. NC_012659.1.

3D structure databases

ProteinModelPortali C3PBG1.
SMRi C3PBG1. Positions 11-213.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 592021.BAA_4959.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ50325 ; ACQ50325 ; BAA_4959 .
GeneIDi 7851430.
KEGGi bai:BAA_4959.
PATRICi 18775818. VBIBacAnt132916_5219.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000251689.
KOi K03439.
OMAi DNVMTEY.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci BANT592021:GJAQ-4905-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Bacillus anthracis A0248."
    Dodson R.J., Munk A.C., Bruce D., Detter C., Tapia R., Sutton G., Sims D., Brettin T.
    Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A0248.

Entry informationi

Entry nameiTRMB_BACAA
AccessioniPrimary (citable) accession number: C3PBG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: June 11, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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