C3PAZ0 (IOLC_BACAA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5-dehydro-2-deoxygluconokinase
EC=2.7.1.92

Alternative name(s):
2-deoxy-5-keto-D-gluconate kinase
Short name=DKG kinase

Gene names

Name:	iolC
Ordered Locus Names:	BAA_2568

Organism

Bacillus anthracis (strain A0248) [Complete proteome] [HAMAP]

Taxonomic identifier

592021 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group › Bacillus anthracis

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D-gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP) By similarity. HAMAP-Rule MF_01668
Catalytic activity	ATP + 5-dehydro-2-deoxy-D-gluconate = ADP + 6-phospho-5-dehydro-2-deoxy-D-gluconate. HAMAP-Rule MF_01668
Pathway	Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 5/7. HAMAP-Rule MF_01668
Sequence similarities	Belongs to the carbohydrate kinase PfkB family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	inositol catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	5-dehydro-2-deoxygluconokinase activity Inferred from electronic annotation. Source: HAMAP ATP binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	5-dehydro-2-deoxygluconokinase HAMAP-Rule MF_01668		PRO_1000187303

Sequences

	Sequence		Length	Mass (Da)
	C3PAZ0 [UniParc]. Last modified June 16, 2009. Version 1. Checksum: D6A7BCA70DB25043	FASTA	332	36,663
	10 20 30 40 50 60 MNPLIFKENR PFDLIAVGRL CVDLNANETQ RPMEETRTFT KYVGGSPANI AIGAARLGLQ 70 80 90 100 110 120 TGFIGKVSDD QMGRFITGYL KDNKINTDQI PIDCTGAVTG LAFTEIKSPE DCSILMYRDN 130 140 150 160 170 180 VADLNLDPTE VSEDYIKQSK ALLISGTALA KSPSREAVFL ALEYARKHDV VVFFDVDYRP 190 200 210 220 230 240 YTWQSEAETA VYYNLAAEKS DVIIGTREEF DMMEKLLNYE KSNDQVTAER WFSHHAKIVV 250 260 270 280 290 300 IKHGGDGSIA YTRDGQSHRG GIFKTKVLKT FGAGDSYASA FIYGLMQGLE IPQAMRLGGA 310 320 330 SASIVISKHS CSDAMPTRAE ISAFMETAEE LV

References

[1]	"Genome sequence of Bacillus anthracis A0248." Dodson R.J., Munk A.C., Bruce D., Detter C., Tapia R., Sutton G., Sims D., Brettin T. Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: A0248.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001598 Genomic DNA. Translation: ACQ48015.1.
RefSeq	YP_002866833.1. NC_012659.1.
3D structure databases
ProteinModelPortal	C3PAZ0.
SMR	C3PAZ0. Positions 5-331.
ModBase	Search...
Protein-protein interaction databases
STRING	592021.BAA_2568.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACQ48015; ACQ48015; BAA_2568.
GeneID	7852178.
KEGG	bai:BAA_2568.
PATRIC	18770955. VBIBacAnt132916_2797.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0524.
HOGENOM	HOG000235951.
KO	K03338.
OMA	ANEINRP.
ProtClustDB	CLSK873289.
Enzyme and pathway databases
BioCyc	BANT592021:GJAQ-2533-MONOMER.
UniPathway	UPA00076; UER00146.
Family and domain databases
HAMAP	MF_01668. IolC.
InterPro	IPR002173. Carboh/pur_kinase_PfkB_CS. IPR022841. DKG_kinase. IPR011611. PfkB_dom. [Graphical view]
Pfam	PF00294. PfkB. 1 hit. [Graphical view]
PROSITE	PS00583. PFKB_KINASES_1. False negative. PS00584. PFKB_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLC_BACAA

Accession

Primary (citable) accession number: C3PAZ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	June 16, 2009
Last modified:	May 1, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program