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C3PAI2

- C3PAI2_BACAA

UniProt

C3PAI2 - C3PAI2_BACAA

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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Bacillus anthracis (strain A0248)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciBANT592021:GJAQ-4796-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:BAA_4849Imported
OrganismiBacillus anthracis (strain A0248)Imported
Taxonomic identifieri592021 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000002335: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi592021.BAA_4849.

Structurei

3D structure databases

ProteinModelPortaliC3PAI2.
SMRiC3PAI2. Positions 1-423.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiCLRPIRY.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3PAI2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTGEKITVT NGVMNVPNNP IIPFIEGDGI GPDIWAAASR VLEAAVEKAY
60 70 80 90 100
DGEKKIVWKE VLAGEKAFNQ TGEWLPEETL NLIREYLIAI KGPLTTPVGG
110 120 130 140 150
GIRSLNVALR QELDLYVCLR PVRYFEGVPS PVKRPEDTDM VIFRENTEDI
160 170 180 190 200
YAGIEYAQGS PEAEKVLAFL KEAMGVNKIR FPETSGIGIK PISEEGTKRL
210 220 230 240 250
VRAAIQYAIN EKRSSVTLVH KGNIMKFTEG AFKNWGYEVA EQEFGDKVFT
260 270 280 290 300
WAEYDRIVEK DGKDAANKAM ADAEVAGKII VKDSIADIFL QQILTRPREF
310 320 330 340 350
DVVATMNLNG DYISDALAAQ VGGIGIAPGA NINYVTGHAI FEATHGTAPK
360 370 380 390 400
YAGLDKVNPS SVLLSGVLLL EHLGWNEAAK LVTASVEKTI ASKVVTYDFA
410 420 430
RLMEGATEVK CSEFANELIK NMDVAIIKNA
Length:430
Mass (Da):46,973
Last modified:June 16, 2009 - v1
Checksum:i2238E99660A705F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001598 Genomic DNA. Translation: ACQ49570.1.
RefSeqiYP_002868872.1. NC_012659.1.

Genome annotation databases

EnsemblBacteriaiACQ49570; ACQ49570; BAA_4849.
GeneIDi7848029.
KEGGibai:BAA_4849.
PATRICi18775597. VBIBacAnt132916_5109.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001598 Genomic DNA. Translation: ACQ49570.1 .
RefSeqi YP_002868872.1. NC_012659.1.

3D structure databases

ProteinModelPortali C3PAI2.
SMRi C3PAI2. Positions 1-423.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 592021.BAA_4849.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ49570 ; ACQ49570 ; BAA_4849 .
GeneIDi 7848029.
KEGGi bai:BAA_4849.
PATRICi 18775597. VBIBacAnt132916_5109.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000021113.
KOi K00031.
OMAi CLRPIRY.
OrthoDBi EOG6SNDTP.

Enzyme and pathway databases

BioCyci BANT592021:GJAQ-4796-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Bacillus anthracis A0248."
    Dodson R.J., Munk A.C., Bruce D., Detter C., Tapia R., Sutton G., Sims D., Brettin T.
    Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A0248Imported.

Entry informationi

Entry nameiC3PAI2_BACAA
AccessioniPrimary (citable) accession number: C3PAI2
Entry historyi
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: November 26, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3