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C3PAI2

- C3PAI2_BACAA

UniProt

C3PAI2 - C3PAI2_BACAA

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Bacillus anthracis (strain A0248)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciBANT592021:GJAQ-4796-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:icdImported
    Ordered Locus Names:BAA_4849Imported
    OrganismiBacillus anthracis (strain A0248)Imported
    Taxonomic identifieri592021 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000002335: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi592021.BAA_4849.

    Structurei

    3D structure databases

    ProteinModelPortaliC3PAI2.
    SMRiC3PAI2. Positions 1-423.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    HOGENOMiHOG000021113.
    KOiK00031.
    OMAiCLRPIRY.
    OrthoDBiEOG6SNDTP.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C3PAI2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTGEKITVT NGVMNVPNNP IIPFIEGDGI GPDIWAAASR VLEAAVEKAY    50
    DGEKKIVWKE VLAGEKAFNQ TGEWLPEETL NLIREYLIAI KGPLTTPVGG 100
    GIRSLNVALR QELDLYVCLR PVRYFEGVPS PVKRPEDTDM VIFRENTEDI 150
    YAGIEYAQGS PEAEKVLAFL KEAMGVNKIR FPETSGIGIK PISEEGTKRL 200
    VRAAIQYAIN EKRSSVTLVH KGNIMKFTEG AFKNWGYEVA EQEFGDKVFT 250
    WAEYDRIVEK DGKDAANKAM ADAEVAGKII VKDSIADIFL QQILTRPREF 300
    DVVATMNLNG DYISDALAAQ VGGIGIAPGA NINYVTGHAI FEATHGTAPK 350
    YAGLDKVNPS SVLLSGVLLL EHLGWNEAAK LVTASVEKTI ASKVVTYDFA 400
    RLMEGATEVK CSEFANELIK NMDVAIIKNA 430
    Length:430
    Mass (Da):46,973
    Last modified:June 16, 2009 - v1
    Checksum:i2238E99660A705F3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001598 Genomic DNA. Translation: ACQ49570.1.
    RefSeqiYP_002868872.1. NC_012659.1.

    Genome annotation databases

    EnsemblBacteriaiACQ49570; ACQ49570; BAA_4849.
    GeneIDi7848029.
    KEGGibai:BAA_4849.
    PATRICi18775597. VBIBacAnt132916_5109.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001598 Genomic DNA. Translation: ACQ49570.1 .
    RefSeqi YP_002868872.1. NC_012659.1.

    3D structure databases

    ProteinModelPortali C3PAI2.
    SMRi C3PAI2. Positions 1-423.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 592021.BAA_4849.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACQ49570 ; ACQ49570 ; BAA_4849 .
    GeneIDi 7848029.
    KEGGi bai:BAA_4849.
    PATRICi 18775597. VBIBacAnt132916_5109.

    Phylogenomic databases

    eggNOGi COG0538.
    HOGENOMi HOG000021113.
    KOi K00031.
    OMAi CLRPIRY.
    OrthoDBi EOG6SNDTP.

    Enzyme and pathway databases

    BioCyci BANT592021:GJAQ-4796-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Bacillus anthracis A0248."
      Dodson R.J., Munk A.C., Bruce D., Detter C., Tapia R., Sutton G., Sims D., Brettin T.
      Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: A0248Imported.

    Entry informationi

    Entry nameiC3PAI2_BACAA
    AccessioniPrimary (citable) accession number: C3PAI2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 16, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3