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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Bacillus anthracis (strain A0248)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Note: Binds 1 magnesium or manganese ion per subunit.
  • Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciBANT592021:GJAQ-4796-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:BAA_4849Imported
OrganismiBacillus anthracis (strain A0248)Imported
Taxonomic identifieri592021 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000002335 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi592021.BAA_4849.

Structurei

3D structure databases

ProteinModelPortaliC3PAI2.
SMRiC3PAI2. Positions 1-423.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiFRDWGYE.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3PAI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTGEKITVT NGVMNVPNNP IIPFIEGDGI GPDIWAAASR VLEAAVEKAY
60 70 80 90 100
DGEKKIVWKE VLAGEKAFNQ TGEWLPEETL NLIREYLIAI KGPLTTPVGG
110 120 130 140 150
GIRSLNVALR QELDLYVCLR PVRYFEGVPS PVKRPEDTDM VIFRENTEDI
160 170 180 190 200
YAGIEYAQGS PEAEKVLAFL KEAMGVNKIR FPETSGIGIK PISEEGTKRL
210 220 230 240 250
VRAAIQYAIN EKRSSVTLVH KGNIMKFTEG AFKNWGYEVA EQEFGDKVFT
260 270 280 290 300
WAEYDRIVEK DGKDAANKAM ADAEVAGKII VKDSIADIFL QQILTRPREF
310 320 330 340 350
DVVATMNLNG DYISDALAAQ VGGIGIAPGA NINYVTGHAI FEATHGTAPK
360 370 380 390 400
YAGLDKVNPS SVLLSGVLLL EHLGWNEAAK LVTASVEKTI ASKVVTYDFA
410 420 430
RLMEGATEVK CSEFANELIK NMDVAIIKNA
Length:430
Mass (Da):46,973
Last modified:June 16, 2009 - v1
Checksum:i2238E99660A705F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001598 Genomic DNA. Translation: ACQ49570.1.
RefSeqiYP_002868872.1. NC_012659.1.

Genome annotation databases

EnsemblBacteriaiACQ49570; ACQ49570; BAA_4849.
KEGGibai:BAA_4849.
PATRICi18775597. VBIBacAnt132916_5109.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001598 Genomic DNA. Translation: ACQ49570.1.
RefSeqiYP_002868872.1. NC_012659.1.

3D structure databases

ProteinModelPortaliC3PAI2.
SMRiC3PAI2. Positions 1-423.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi592021.BAA_4849.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACQ49570; ACQ49570; BAA_4849.
KEGGibai:BAA_4849.
PATRICi18775597. VBIBacAnt132916_5109.

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiFRDWGYE.
OrthoDBiEOG6SNDTP.

Enzyme and pathway databases

BioCyciBANT592021:GJAQ-4796-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Bacillus anthracis A0248."
    Dodson R.J., Munk A.C., Bruce D., Detter C., Tapia R., Sutton G., Sims D., Brettin T.
    Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A0248Imported.

Entry informationi

Entry nameiC3PAI2_BACAA
AccessioniPrimary (citable) accession number: C3PAI2
Entry historyi
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: April 1, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.