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Protein

DNA-directed RNA polymerase subunit beta

Gene

rpoB

Organism
Bacillus anthracis (strain A0248)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit betaUniRule annotation
Alternative name(s):
RNA polymerase subunit betaUniRule annotation
Transcriptase subunit betaUniRule annotation
Gene namesi
Name:rpoBUniRule annotation
Ordered Locus Names:BAA_0118
OrganismiBacillus anthracis (strain A0248)
Taxonomic identifieri592021 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001657861 – 1177DNA-directed RNA polymerase subunit betaAdd BLAST1177

Proteomic databases

PRIDEiC3P9P7.

Interactioni

Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC3P9P7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218611.
KOiK03043.
OMAiYFNPKRY.

Family and domain databases

CDDicd00653. RNA_pol_B_RPB2. 1 hit.
Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 2 hits.
HAMAPiMF_01321. RNApol_bact_RpoB. 1 hit.
InterProiIPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR010243. RNA_pol_bsu_bac.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 2 hits.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3P9P7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGQLVQYGR HRQRRSYARI SEVLELPNLI EIQTSSYQWF LDEGLREMFQ
60 70 80 90 100
DISPIEDFTG NLSLEFIDYS LGEPKYSVDE CKERDVTYAA PLRVKVRLIN
110 120 130 140 150
KETGEVKEQD VFMGDFPLMT ETGTFVINGA ERVIVSQLVR SPSVYYSGKV
160 170 180 190 200
DKNGKRGFTA TVIPNRGAWL EYETDAKDVV YVRIDRTRKL PVTVLLRALG
210 220 230 240 250
FGSDQEITEL LGDNEYLSNT LEKDNTDSTE KALLEIYERL RPGEPPTVEN
260 270 280 290 300
AKSLLVSRFF DPKRYDLANV GRYKINKKLH IKNRLFNQRL AETLVDPETG
310 320 330 340 350
EILAAEGTIL DRRTLDRILP YLEKNIGFKT AKPMGGVVEG DVELQSIKIY
360 370 380 390 400
APESEGERVI NVIGNANITR DVKHITPGDI LASISYFFNL LYKVGDTDDI
410 420 430 440 450
DHLGNRRLRS VGELLQNQFR IGLSRMERVV RERMSIQDTN AITPQALINI
460 470 480 490 500
RPVIAAIKEF FGSSQLSQFM DQTNPLAELT HKRRLSALGP GGLTRERAGF
510 520 530 540 550
EVRDVHYSHY GRMCPIETPE GPNIGLINSL SSFAKVNEFG FIETPYRRVD
560 570 580 590 600
PETGLVTGHV DYLTADEEDN YVVAQANMKL SEEGEFLDED IVARFRGENI
610 620 630 640 650
VTNKERIDYM DVSPKQVVSA ATACIPFLEN DDSNRALMGA NMQRQAVPLM
660 670 680 690 700
NPESPIVGTG MEYVSAKDSG AAVICKHPGI VERVEAREVW VRRYVEVDGQ
710 720 730 740 750
TVKGDLDRYK MQKFIRSNQG TCYNQRPIVS VGNEVVKGEI LADGPSMELG
760 770 780 790 800
ELALGRNVLV GFMTWDGYNY EDAIIMSERL VKDDVYTSIH IEEYESEARD
810 820 830 840 850
TKLGPEEITR DIPNVGEDAL RNLDERGIIR VGAEVKDGDL LVGKVTPKGV
860 870 880 890 900
TELTAEERLL HAIFGEKARE VRDTSLRVPH GGGGIILDVK VFNREDGDEL
910 920 930 940 950
PPGVNQLVRA YIVQKRKISE GDKMAGRHGN KGVISRILPE EDMPYLPDGT
960 970 980 990 1000
PIDIMLNPLG VPSRMNIGQV LELHLGMAAR YLGIHIATPV FDGAREEDVW
1010 1020 1030 1040 1050
GTIEEAGMAN DAKTILYDGR TGEPFDNRVS VGVMYMIKLA HMVDDKLHAR
1060 1070 1080 1090 1100
STGPYSLVTQ QPLGGKAQFG GQRFGEMEVW ALEAYGAAYT LQEILTVKSD
1110 1120 1130 1140 1150
DVIGRVKTYE AIVKGENVPE PGVPESFKVL IKELQSLGMD VKMMSSDDTE
1160 1170
IEMRDTEDDD DHQSADKLNV EVETTKE
Length:1,177
Mass (Da):131,891
Last modified:June 16, 2009 - v1
Checksum:i9546E19403E29B01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001598 Genomic DNA. Translation: ACQ46691.1.
RefSeqiWP_000147548.1. NC_012659.1.

Genome annotation databases

EnsemblBacteriaiACQ46691; ACQ46691; BAA_0118.
KEGGibai:BAA_0118.
PATRICi18765992. VBIBacAnt132916_0409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001598 Genomic DNA. Translation: ACQ46691.1.
RefSeqiWP_000147548.1. NC_012659.1.

3D structure databases

ProteinModelPortaliC3P9P7.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiC3P9P7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACQ46691; ACQ46691; BAA_0118.
KEGGibai:BAA_0118.
PATRICi18765992. VBIBacAnt132916_0409.

Phylogenomic databases

HOGENOMiHOG000218611.
KOiK03043.
OMAiYFNPKRY.

Family and domain databases

CDDicd00653. RNA_pol_B_RPB2. 1 hit.
Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 2 hits.
HAMAPiMF_01321. RNApol_bact_RpoB. 1 hit.
InterProiIPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR010243. RNA_pol_bsu_bac.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 2 hits.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRPOB_BACAA
AccessioniPrimary (citable) accession number: C3P9P7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: November 2, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.