C3P6Y7 (DAPEL_BACAA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyldiaminopimelate deacetylase
EC=3.5.1.47

Gene names

Ordered Locus Names:

BAA_4215

Organism

Bacillus anthracis (strain A0248) [Complete proteome] [HAMAP]

Taxonomic identifier

592021 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group › Bacillus anthracis

Protein attributes

Sequence length	376 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate By similarity. HAMAP-Rule MF_01692
Catalytic activity	N-acetyl-LL-2,6-diaminoheptanedioate + H2O = acetate + LL-2,6-diaminoheptanedioate. HAMAP-Rule MF_01692
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 3/3. HAMAP-Rule MF_01692
Sequence similarities	Belongs to the peptidase M20A family. N-acetyldiaminopimelate deacetylase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP lysine biosynthetic process via diaminopimelate Inferred from electronic annotation. Source: HAMAP
Molecular_function	N-acetyldiaminopimelate deacetylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 376	376	N-acetyldiaminopimelate deacetylase HAMAP-Rule MF_01692		PRO_1000187456
Sites
	Active site	69	1	By similarity
	Active site	128	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	C3P6Y7 [UniParc]. Last modified June 16, 2009. Version 1. Checksum: 4B223711A14D38CC	FASTA	376	41,896
	10 20 30 40 50 60 MAVSKFVQIR RDLHKIPEIG FKEWKTQQYI LDYIGTLSNE HVEVKVWRTG VIVKVKGKNP 70 80 90 100 110 120 EKVIGYRADI DGLPITEETG YEFASVHEGM MHACGHDLHT TIGLGLLTAA VTERIDDDLV 130 140 150 160 170 180 FLFQPAEEGP GGALPMLESE ELKEWKPNII LGLHIAPEYP VGTIATKEGL LFANTSELYV 190 200 210 220 230 240 DLKGKGGHAA YPHTANDMIV AASHLVTQLQ SVISRNVNPL DSAVITIGKI TGGTVQNIIA 250 260 270 280 290 300 EKSRLEGTIR TLSVESMSRV KSRIEAIVAG IEASFQCEAV IDYGAMYHQV YNHEALTREF 310 320 330 340 350 360 MQFVSEQTDM KVITCTEAMT GEDFGYMLQE IPGFMFWLGV NSEYGLHHAK LRPDEEAIEK 370 AIVFLDQYVK WKGTRK

References

[1]	"Genome sequence of Bacillus anthracis A0248." Dodson R.J., Munk A.C., Bruce D., Detter C., Tapia R., Sutton G., Sims D., Brettin T. Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: A0248.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001598 Genomic DNA. Translation: ACQ49954.1.
RefSeq	YP_002868280.1. NC_012659.1.
3D structure databases
ProteinModelPortal	C3P6Y7.
ModBase	Search...
Protein-protein interaction databases
STRING	592021.BAA_4215.
Protein family/group databases
MEROPS	M20.A27.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACQ49954; ACQ49954; BAA_4215.
GeneID	7851390.
KEGG	bai:BAA_4215.
PATRIC	18774319. VBIBacAnt132916_4473.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1473.
HOGENOM	HOG000241404.
KO	K05823.
OMA	VVSKFVQ.
ProtClustDB	CLSK873387.
Enzyme and pathway databases
BioCyc	BANT592021:GJAQ-4169-MONOMER.
UniPathway	UPA00034; UER00024.
Family and domain databases
HAMAP	MF_01692. DapEL.
InterPro	IPR023905. AcetylDAP_deacetylase. IPR017439. Amidohydrolase. IPR002933. Peptidase_M20. IPR011650. Peptidase_M20_dimer. [Graphical view]
Pfam	PF07687. M20_dimer. 1 hit. PF01546. Peptidase_M20. 1 hit. [Graphical view]
PIRSF	PIRSF005962. Pept_M20D_amidohydro. 1 hit.
SUPFAM	SSF55031. Peptidase_M20_dimer. 1 hit.
TIGRFAMs	TIGR01891. amidohydrolases. 1 hit.
PROSITE	PS00758. ARGE_DAPE_CPG2_1. False negative. PS00759. ARGE_DAPE_CPG2_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPEL_BACAA

Accession

Primary (citable) accession number: C3P6Y7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	June 16, 2009
Last modified:	May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program