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C3P598 (GCH1_BACAA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:BAA_1601
OrganismBacillus anthracis (strain A0248) [Complete proteome] [HAMAP]
Taxonomic identifier592021 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length189 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Homopolymer By similarity. HAMAP-Rule MF_00223

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 189189GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_1000124906

Sites

Metal binding781Zinc By similarity
Metal binding811Zinc By similarity
Metal binding1501Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
C3P598 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: 0A8B0379657B322B

FASTA18921,020
        10         20         30         40         50         60 
MAKVNLEQIE HAVRLILEAI GDDPNREGVL DTPKRVAKMY AEVFSGMHED PKEHLHKVFG 

        70         80         90        100        110        120 
EDHEELVLVK DIPFYSMCEH HLVPFYGVAH VAYIPQGGKV TGLSKLARTV DTIARRPQLQ 

       130        140        150        160        170        180 
ERITSTVANS IMEVLEPHGV MVVVEAEHMC MTMRGVKKPG AKTVTTAVRG VLENDAAARS 


EILSFIKTK 

« Hide

References

[1]"Genome sequence of Bacillus anthracis A0248."
Dodson R.J., Munk A.C., Bruce D., Detter C., Tapia R., Sutton G., Sims D., Brettin T.
Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: A0248.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001598 Genomic DNA. Translation: ACQ48362.1.
RefSeqYP_002866014.1. NC_012659.1.

3D structure databases

ProteinModelPortalC3P598.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING592021.BAA_1601.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACQ48362; ACQ48362; BAA_1601.
GeneID7848097.
KEGGbai:BAA_1601.
PATRIC18768972. VBIBacAnt132916_1814.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0302.
HOGENOMHOG000221222.
KOK01495.
OMARKPGAVT.
OrthoDBEOG6XHC8G.
ProtClustDBPRK09347.

Enzyme and pathway databases

BioCycBANT592021:GJAQ-1573-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_BACAA
AccessionPrimary (citable) accession number: C3P598
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: June 16, 2009
Last modified: February 19, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways