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C3NVQ6

- C3NVQ6_VIBCJ

UniProt

C3NVQ6 - C3NVQ6_VIBCJ

Protein

Beta-galactosidase

Gene

lacZ

Organism
Vibrio cholerae serotype O1 (strain MJ-1236)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (16 Jun 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 sodium ion per monomer.UniRule annotation
    Binds 2 magnesium ions per monomer.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei120 – 1201SubstrateUniRule annotation
    Metal bindingi218 – 2181SodiumUniRule annotation
    Binding sitei218 – 2181SubstrateUniRule annotation
    Sitei375 – 3751Transition state stabilizerUniRule annotation
    Sitei409 – 4091Transition state stabilizerUniRule annotation
    Metal bindingi434 – 4341Magnesium 1UniRule annotation
    Metal bindingi436 – 4361Magnesium 1UniRule annotation
    Active sitei479 – 4791Proton donorUniRule annotation
    Metal bindingi479 – 4791Magnesium 1UniRule annotation
    Binding sitei479 – 4791SubstrateUniRule annotation
    Active sitei555 – 5551NucleophileUniRule annotation
    Metal bindingi615 – 6151Magnesium 2UniRule annotation
    Metal bindingi619 – 6191Sodium; via carbonyl oxygenUniRule annotation
    Metal bindingi622 – 6221SodiumUniRule annotation
    Binding sitei622 – 6221SubstrateUniRule annotation
    Binding sitei1015 – 10151SubstrateUniRule annotation

    GO - Molecular functioni

    1. beta-galactosidase activity Source: UniProtKB-EC
    2. carbohydrate binding Source: InterPro
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    GlycosidaseUniRule annotationSAAS annotationImported, Hydrolase

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation, SodiumUniRule annotation

    Enzyme and pathway databases

    BioCyciVCHO593588:GI2R-1063-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-galactosidaseUniRule annotation (EC:3.2.1.23UniRule annotation)
    Short name:
    Beta-galUniRule annotation
    Alternative name(s):
    LactaseUniRule annotation
    Gene namesi
    Name:lacZUniRule annotation
    Ordered Locus Names:VCD_002010Imported
    OrganismiVibrio cholerae serotype O1 (strain MJ-1236)Imported
    Taxonomic identifieri593588 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000001618: Chromosome 1

    Subcellular locationi

    GO - Cellular componenti

    1. beta-galactosidase complex Source: InterPro

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi593588.VCD_002010.

    Structurei

    3D structure databases

    ProteinModelPortaliC3NVQ6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni555 – 5584Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 2 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3250.
    HOGENOMiHOG000252443.
    KOiK01190.
    OMAiNPPFVPK.
    OrthoDBiEOG6XWV0T.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    2.60.40.320. 2 hits.
    2.70.98.10. 1 hit.
    3.20.20.80. 1 hit.
    HAMAPiMF_01687. Beta_gal.
    InterProiIPR004199. B-gal_small/dom_5.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR008979. Galactose-bd-like.
    IPR014718. Glyco_hydro-type_carb-bd_sub.
    IPR006101. Glyco_hydro_2.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR023232. Glyco_hydro_2_AS.
    IPR023933. Glyco_hydro_2_beta_Galsidase.
    IPR023230. Glyco_hydro_2_CS.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR006104. Glyco_hydro_2_N.
    IPR006103. Glyco_hydro_2_TIM.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF02929. Bgal_small_N. 1 hit.
    PF00703. Glyco_hydro_2. 1 hit.
    PF02836. Glyco_hydro_2_C. 1 hit.
    PF02837. Glyco_hydro_2_N. 1 hit.
    [Graphical view]
    PRINTSiPR00132. GLHYDRLASE2.
    SMARTiSM01038. Bgal_small_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF49303. SSF49303. 2 hits.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    SSF74650. SSF74650. 1 hit.
    PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
    PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C3NVQ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYAVEQRRYW LVASRIQEDL MRNFSDILLS QDWQNPHIVK WHCRTPHVPL     50
    HSYRTEQEAR LDVGGNRQSL NGQWRFALFE KPEAVEPAVI DPDFDDSAWA 100
    HIPVPSNWQM QGFDKPIYTN IQYPFADRPP YVPQDNPTGC YRHRFTLEKQ 150
    ALTESIRIVF DGVNSAFHLW CNGHWVGYSQ DSRLPAEFEL TPYLQEGENL 200
    LVAMVLRWSD GSYLEDQDMW WLSGIFRDVY LYRKPILAIE DFFIRTELDA 250
    LYQHAELRVE TRLSQVTRHH QVQVALFDAQ GECVARSQAL HTGQRVVDEK 300
    GAWHDKTEHS LAICSPTLWS DEAPYLYRCV ICLLDEDGAP IEFESAAVGF 350
    RKVEITQGLL KLNGQPLLIR GVNRHEHHPE LGHVMDEASM RRDIELMKQH 400
    NFNAVRTAHY PNHPRWYELC DEYGLYVVDE ANLETHGQFP MSRLSNDPQW 450
    VNAYLQRMIG MVERDKNHPC VIIWSLGNES GIGTNHHAMY QWTKQRDPSR 500
    PVQYEGGGAN TAATDIVCPM YARVDQHQPH PAVPKYALKN WISLPQENRP 550
    LILCEYAHAM GNSLGAFYKY WQAFREFPRL QGGFIWDWVD QGISKWDSEG 600
    RHYWGYGGDF GDTINDRQFC INGLLFPDRT PHPALHEVKK VQQPYQFSLS 650
    YPKLTIHNER LFAALPLELV VSVLCDGQEI KQERLPLDIA PRGTITLDLA 700
    SLPMLPEHEY HLNAVLLCRE DQPWSNAGHC IASEQWCLQP RRSMLPKITH 750
    APLPQWQQDG DKVRIEAANQ QWQFNRQTGL LEQWWQNGQP VLSEPLRDNF 800
    YRAVLDNDIG TSEAQHLDPN SWIARWHAAG LDKLRVECDD LRVTTLNESV 850
    EVVIDVAHYH QQALALRTRW RYQIFGDARV ELNVEVMLCS DLPPLPRVGL 900
    TLALPVAENP VSWFGRGPHE NYPDRLQSAH VGRYTATVDE LHTPYIFPSE 950
    NGLRCDTRQL QVGALVVEGH FHFSLSRYSQ TMLDKAKHSN ELVAGDKWYL 1000
    NLDAQHMGVG GDDSWSQSVH PEFLLTQPHY QYQLTLRVKA SSPQ 1044
    Length:1,044
    Mass (Da):120,685
    Last modified:June 16, 2009 - v1
    Checksum:i2AF5D57EC04B6908
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001485 Genomic DNA. Translation: ACQ60179.1.
    RefSeqiYP_002877749.1. NC_012668.1.

    Genome annotation databases

    EnsemblBacteriaiACQ60179; ACQ60179; VCD_002010.
    GeneIDi7855259.
    KEGGivcj:VCD_002010.
    PATRICi20075382. VBIVibCho20143_2033.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001485 Genomic DNA. Translation: ACQ60179.1 .
    RefSeqi YP_002877749.1. NC_012668.1.

    3D structure databases

    ProteinModelPortali C3NVQ6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 593588.VCD_002010.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACQ60179 ; ACQ60179 ; VCD_002010 .
    GeneIDi 7855259.
    KEGGi vcj:VCD_002010.
    PATRICi 20075382. VBIVibCho20143_2033.

    Phylogenomic databases

    eggNOGi COG3250.
    HOGENOMi HOG000252443.
    KOi K01190.
    OMAi NPPFVPK.
    OrthoDBi EOG6XWV0T.

    Enzyme and pathway databases

    BioCyci VCHO593588:GI2R-1063-MONOMER.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    2.60.40.320. 2 hits.
    2.70.98.10. 1 hit.
    3.20.20.80. 1 hit.
    HAMAPi MF_01687. Beta_gal.
    InterProi IPR004199. B-gal_small/dom_5.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR008979. Galactose-bd-like.
    IPR014718. Glyco_hydro-type_carb-bd_sub.
    IPR006101. Glyco_hydro_2.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR023232. Glyco_hydro_2_AS.
    IPR023933. Glyco_hydro_2_beta_Galsidase.
    IPR023230. Glyco_hydro_2_CS.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR006104. Glyco_hydro_2_N.
    IPR006103. Glyco_hydro_2_TIM.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF02929. Bgal_small_N. 1 hit.
    PF00703. Glyco_hydro_2. 1 hit.
    PF02836. Glyco_hydro_2_C. 1 hit.
    PF02837. Glyco_hydro_2_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00132. GLHYDRLASE2.
    SMARTi SM01038. Bgal_small_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49303. SSF49303. 2 hits.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    SSF74650. SSF74650. 1 hit.
    PROSITEi PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
    PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MJ-1236Imported.

    Entry informationi

    Entry nameiC3NVQ6_VIBCJ
    AccessioniPrimary (citable) accession number: C3NVQ6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 16, 2009
    Last sequence update: June 16, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3