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C3NVQ6

- C3NVQ6_VIBCJ

UniProt

C3NVQ6 - C3NVQ6_VIBCJ

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Protein
Beta-galactosidase
Gene
lacZ, VCD_002010
Organism
Vibrio cholerae serotype O1 (strain MJ-1236)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.UniRule annotationSAAS annotations

Cofactori

Binds 1 sodium ion per monomer By similarity.UniRule annotation
Binds 2 magnesium ions per monomer By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei120 – 1201Substrate By similarityUniRule annotation
Metal bindingi218 – 2181Sodium By similarityUniRule annotation
Binding sitei218 – 2181Substrate By similarityUniRule annotation
Sitei375 – 3751Transition state stabilizer By similarityUniRule annotation
Sitei409 – 4091Transition state stabilizer By similarityUniRule annotation
Metal bindingi434 – 4341Magnesium 1 By similarityUniRule annotation
Metal bindingi436 – 4361Magnesium 1 By similarityUniRule annotation
Active sitei479 – 4791Proton donor By similarityUniRule annotation
Metal bindingi479 – 4791Magnesium 1 By similarityUniRule annotation
Binding sitei479 – 4791Substrate By similarityUniRule annotation
Active sitei555 – 5551Nucleophile By similarityUniRule annotation
Metal bindingi615 – 6151Magnesium 2 By similarityUniRule annotation
Metal bindingi619 – 6191Sodium; via carbonyl oxygen By similarityUniRule annotation
Metal bindingi622 – 6221Sodium By similarityUniRule annotation
Binding sitei622 – 6221Substrate By similarityUniRule annotation
Binding sitei1015 – 10151Substrate By similarityUniRule annotation

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotationSAAS annotationsImported, Hydrolase

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation, SodiumUniRule annotation

Enzyme and pathway databases

BioCyciVCHO593588:GI2R-1063-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidaseUniRule annotation (EC:3.2.1.23UniRule annotation)
Short name:
Beta-galUniRule annotation
Alternative name(s):
Lactase
Gene namesi
Name:lacZUniRule annotation
Ordered Locus Names:VCD_002010Imported
OrganismiVibrio cholerae serotype O1 (strain MJ-1236)Imported
Taxonomic identifieri593588 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000001618: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  1. beta-galactosidase complex Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi593588.VCD_002010.

Structurei

3D structure databases

ProteinModelPortaliC3NVQ6.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni555 – 5584Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Belongs to the glycosyl hydrolase 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3250.
HOGENOMiHOG000252443.
KOiK01190.
OMAiNPPFVPK.
OrthoDBiEOG6XWV0T.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
HAMAPiMF_01687. Beta_gal.
InterProiIPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023933. Glyco_hydro_2_beta_Galsidase.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02929. Bgal_small_N. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSiPR00132. GLHYDRLASE2.
SMARTiSM01038. Bgal_small_N. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3NVQ6-1 [UniParc]FASTAAdd to Basket

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MYAVEQRRYW LVASRIQEDL MRNFSDILLS QDWQNPHIVK WHCRTPHVPL     50
HSYRTEQEAR LDVGGNRQSL NGQWRFALFE KPEAVEPAVI DPDFDDSAWA 100
HIPVPSNWQM QGFDKPIYTN IQYPFADRPP YVPQDNPTGC YRHRFTLEKQ 150
ALTESIRIVF DGVNSAFHLW CNGHWVGYSQ DSRLPAEFEL TPYLQEGENL 200
LVAMVLRWSD GSYLEDQDMW WLSGIFRDVY LYRKPILAIE DFFIRTELDA 250
LYQHAELRVE TRLSQVTRHH QVQVALFDAQ GECVARSQAL HTGQRVVDEK 300
GAWHDKTEHS LAICSPTLWS DEAPYLYRCV ICLLDEDGAP IEFESAAVGF 350
RKVEITQGLL KLNGQPLLIR GVNRHEHHPE LGHVMDEASM RRDIELMKQH 400
NFNAVRTAHY PNHPRWYELC DEYGLYVVDE ANLETHGQFP MSRLSNDPQW 450
VNAYLQRMIG MVERDKNHPC VIIWSLGNES GIGTNHHAMY QWTKQRDPSR 500
PVQYEGGGAN TAATDIVCPM YARVDQHQPH PAVPKYALKN WISLPQENRP 550
LILCEYAHAM GNSLGAFYKY WQAFREFPRL QGGFIWDWVD QGISKWDSEG 600
RHYWGYGGDF GDTINDRQFC INGLLFPDRT PHPALHEVKK VQQPYQFSLS 650
YPKLTIHNER LFAALPLELV VSVLCDGQEI KQERLPLDIA PRGTITLDLA 700
SLPMLPEHEY HLNAVLLCRE DQPWSNAGHC IASEQWCLQP RRSMLPKITH 750
APLPQWQQDG DKVRIEAANQ QWQFNRQTGL LEQWWQNGQP VLSEPLRDNF 800
YRAVLDNDIG TSEAQHLDPN SWIARWHAAG LDKLRVECDD LRVTTLNESV 850
EVVIDVAHYH QQALALRTRW RYQIFGDARV ELNVEVMLCS DLPPLPRVGL 900
TLALPVAENP VSWFGRGPHE NYPDRLQSAH VGRYTATVDE LHTPYIFPSE 950
NGLRCDTRQL QVGALVVEGH FHFSLSRYSQ TMLDKAKHSN ELVAGDKWYL 1000
NLDAQHMGVG GDDSWSQSVH PEFLLTQPHY QYQLTLRVKA SSPQ 1044
Length:1,044
Mass (Da):120,685
Last modified:June 16, 2009 - v1
Checksum:i2AF5D57EC04B6908
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001485 Genomic DNA. Translation: ACQ60179.1.
RefSeqiYP_002877749.1. NC_012668.1.

Genome annotation databases

EnsemblBacteriaiACQ60179; ACQ60179; VCD_002010.
GeneIDi7855259.
KEGGivcj:VCD_002010.
PATRICi20075382. VBIVibCho20143_2033.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001485 Genomic DNA. Translation: ACQ60179.1 .
RefSeqi YP_002877749.1. NC_012668.1.

3D structure databases

ProteinModelPortali C3NVQ6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 593588.VCD_002010.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACQ60179 ; ACQ60179 ; VCD_002010 .
GeneIDi 7855259.
KEGGi vcj:VCD_002010.
PATRICi 20075382. VBIVibCho20143_2033.

Phylogenomic databases

eggNOGi COG3250.
HOGENOMi HOG000252443.
KOi K01190.
OMAi NPPFVPK.
OrthoDBi EOG6XWV0T.

Enzyme and pathway databases

BioCyci VCHO593588:GI2R-1063-MONOMER.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
HAMAPi MF_01687. Beta_gal.
InterProi IPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023933. Glyco_hydro_2_beta_Galsidase.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF02929. Bgal_small_N. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view ]
PRINTSi PR00132. GLHYDRLASE2.
SMARTi SM01038. Bgal_small_N. 1 hit.
[Graphical view ]
SUPFAMi SSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEi PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MJ-1236.

Entry informationi

Entry nameiC3NVQ6_VIBCJ
AccessioniPrimary (citable) accession number: C3NVQ6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: June 11, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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