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Protein

Site-specific DNA-methyltransferase (adenine-specific)

Gene

VCD_001737

Organism
Vibrio cholerae serotype O1 (strain MJ-1236)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101S-adenosyl-L-methionineUniRule annotation
Binding sitei14 – 141S-adenosyl-L-methionine; via amide nitrogenUniRule annotation
Binding sitei54 – 541S-adenosyl-L-methionineUniRule annotation
Binding sitei181 – 1811S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationImported, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Enzyme and pathway databases

BioCyciVCHO593588:GI2R-782-MONOMER.

Protein family/group databases

REBASEi20839. M.Vch1236DamP.

Names & Taxonomyi

Protein namesi
Recommended name:
Site-specific DNA-methyltransferase (adenine-specific)UniRule annotation (EC:2.1.1.72UniRule annotation)
Gene namesi
Ordered Locus Names:VCD_001737Imported
OrganismiVibrio cholerae serotype O1 (strain MJ-1236)Imported
Taxonomic identifieri593588 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000001618 Componenti: Chromosome 1

Structurei

3D structure databases

ProteinModelPortaliC3NUY3.
SMRiC3NUY3. Positions 3-271.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the N(4)/N(6)-methyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0338.
HOGENOMiHOG000281348.
KOiK06223.
OMAiKARRTIS.
OrthoDBiEOG6CS08V.

Family and domain databases

Gene3Di1.10.1020.10. 1 hit.
3.40.50.150. 2 hits.
InterProiIPR023095. Ade_MeTrfase_dom_2.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR012263. M_m6A_EcoRV.
IPR012327. MeTrfase_D12.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF02086. MethyltransfD12. 1 hit.
[Graphical view]
PIRSFiPIRSF000398. M_m6A_EcoRV. 1 hit.
PRINTSiPR00505. D12N6MTFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00571. dam. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3NUY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKQRAFLKW AGGKYSLVED IQRHLPEARE LVEPFVGAGS VFLNTDFERY
60 70 80 90 100
LLADINPDLI NFYNLLKTEP QAYIHEAKRW FVPENNRKEV YLDIRKQFNQ
110 120 130 140 150
SDDAMFRSLA FLYMNRFGFN GLCRYNKKGG FNVPFGSYKK PYFPEQELEF
160 170 180 190 200
FAEKAQRATF ICASYGETFA RAQSDSVIYC DPPYAPLSTT ANFTSYAGNG
210 220 230 240 250
FTLDDQAALA DIAEKTAKER GISVLISNHD TTHTRRLYRG AQLNVVKANR
260 270
TISRNGAGRN KVDELLALFT PHLSSQA
Length:277
Mass (Da):31,624
Last modified:June 16, 2009 - v1
Checksum:i48D831240F9E7C60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001485 Genomic DNA. Translation: ACQ59906.1.
RefSeqiWP_000744680.1. NC_012668.1.

Genome annotation databases

EnsemblBacteriaiACQ59906; ACQ59906; VCD_001737.
KEGGivcj:VCD_001737.
PATRICi20074814. VBIVibCho20143_1757.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001485 Genomic DNA. Translation: ACQ59906.1.
RefSeqiWP_000744680.1. NC_012668.1.

3D structure databases

ProteinModelPortaliC3NUY3.
SMRiC3NUY3. Positions 3-271.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

REBASEi20839. M.Vch1236DamP.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACQ59906; ACQ59906; VCD_001737.
KEGGivcj:VCD_001737.
PATRICi20074814. VBIVibCho20143_1757.

Phylogenomic databases

eggNOGiCOG0338.
HOGENOMiHOG000281348.
KOiK06223.
OMAiKARRTIS.
OrthoDBiEOG6CS08V.

Enzyme and pathway databases

BioCyciVCHO593588:GI2R-782-MONOMER.

Family and domain databases

Gene3Di1.10.1020.10. 1 hit.
3.40.50.150. 2 hits.
InterProiIPR023095. Ade_MeTrfase_dom_2.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR012263. M_m6A_EcoRV.
IPR012327. MeTrfase_D12.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF02086. MethyltransfD12. 1 hit.
[Graphical view]
PIRSFiPIRSF000398. M_m6A_EcoRV. 1 hit.
PRINTSiPR00505. D12N6MTFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00571. dam. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MJ-1236Imported.

Entry informationi

Entry nameiC3NUY3_VIBCJ
AccessioniPrimary (citable) accession number: C3NUY3
Entry historyi
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: July 22, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.