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Protein

Adenylosuccinate lyase

Gene

VCD_003216

Organism
Vibrio cholerae serotype O1 (strain MJ-1236)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
N(6)-(1,2-dicarboxyethyl)AMP = fumarate + AMP.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity Source: UniProtKB-EC
  2. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' AMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported

Keywords - Biological processi

Purine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciVCHO593588:GI2R-2290-MONOMER.
UniPathwayiUPA00074; UER00132.
UPA00075; UER00336.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylosuccinate lyaseUniRule annotation (EC:4.3.2.2UniRule annotation)
Short name:
ASLUniRule annotation
Alternative name(s):
AdenylosuccinaseUniRule annotation
Gene namesi
Ordered Locus Names:VCD_003216Imported
OrganismiVibrio cholerae serotype O1 (strain MJ-1236)Imported
Taxonomic identifieri593588 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000001618 Componenti: Chromosome 1

Interactioni

Protein-protein interaction databases

STRINGi593588.VCD_003216.

Structurei

3D structure databases

ProteinModelPortaliC3NRN6.
SMRiC3NRN6. Positions 1-456.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0015.
HOGENOMiHOG000252916.
KOiK01756.
OMAiDKNWEVL.
OrthoDBiEOG686NDB.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
IPR004769. Pur_lyase.
IPR013539. PurB_C.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF08328. ASL_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00928. purB. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3NRN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSALTAVS PVDGRYGSKT IALRSIFSEF GLLKYRTIVE IRWLQKLAAT
60 70 80 90 100
AEIAEVPAFS AEANQFLDAI AANFNEADAL RIKEIERTTN HDVKAVEYFL
110 120 130 140 150
KEKVAAMPEL HAVNEFIHFA CTSEDINNTS HALMLKEARD TVILPEIRNV
160 170 180 190 200
IDAIRKLAEE YRDIPLLSRT HGQPASPSTM GKEMANVAYR MERQYKQIAN
210 220 230 240 250
VEILAKINGA VGNYNAHLSA YPTVDWHKFS EEFITESLGV DWNPYTTQIE
260 270 280 290 300
PHDYIAELFE AVARFNTILI DFDRDVWGYI ALGHFKQRTI AGEIGSSTMP
310 320 330 340 350
HKVNPIDFEN SEGNLGLANA VFTHLAQKLP ISRWQRDLTD STVLRNLGVG
360 370 380 390 400
VGYAIIAYTS TLKGISKLEV NRDALLAELD HNWEVLAEPI QTVMRRYGIE
410 420 430 440 450
KPYEKLKELT RGKRVDGEAM RQFIDGLALP AEEKTRLKAM TPASYIGYAI

ELTDKL
Length:456
Mass (Da):51,335
Last modified:June 16, 2009 - v1
Checksum:i1B57F9A5A1FDD859
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001485 Genomic DNA. Translation: ACQ61376.1.
RefSeqiYP_002878946.1. NC_012668.1.

Genome annotation databases

EnsemblBacteriaiACQ61376; ACQ61376; VCD_003216.
GeneIDi7854806.
KEGGivcj:VCD_003216.
PATRICi20077833. VBIVibCho20143_3229.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001485 Genomic DNA. Translation: ACQ61376.1.
RefSeqiYP_002878946.1. NC_012668.1.

3D structure databases

ProteinModelPortaliC3NRN6.
SMRiC3NRN6. Positions 1-456.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi593588.VCD_003216.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACQ61376; ACQ61376; VCD_003216.
GeneIDi7854806.
KEGGivcj:VCD_003216.
PATRICi20077833. VBIVibCho20143_3229.

Phylogenomic databases

eggNOGiCOG0015.
HOGENOMiHOG000252916.
KOiK01756.
OMAiDKNWEVL.
OrthoDBiEOG686NDB.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00132.
UPA00075; UER00336.
BioCyciVCHO593588:GI2R-2290-MONOMER.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
InterProiIPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
IPR004769. Pur_lyase.
IPR013539. PurB_C.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PfamiPF08328. ASL_C. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00928. purB. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MJ-1236Imported.

Entry informationi

Entry nameiC3NRN6_VIBCJ
AccessioniPrimary (citable) accession number: C3NRN6
Entry historyi
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: February 4, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.