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Protein

Succinylglutamate desuccinylase

Gene

astE

Organism
Vibrio cholerae serotype O1 (strain MJ-1236)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transforms N(2)-succinylglutamate into succinate and glutamate.UniRule annotationSAAS annotation

Catalytic activityi

N-succinyl-L-glutamate + H2O = succinate + L-glutamate.UniRule annotationSAAS annotation

Cofactori

Zn2+UniRule annotationSAAS annotationNote: Binds 1 zinc ion per subunit.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi63 – 631ZincUniRule annotation
Metal bindingi66 – 661ZincUniRule annotation
Metal bindingi155 – 1551ZincUniRule annotation
Active sitei219 – 2191UniRule annotation

GO - Molecular functioni

  1. hydrolase activity, acting on ester bonds Source: UniProtKB-HAMAP
  2. succinylglutamate desuccinylase activity Source: UniProtKB-EC
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine catabolic process to glutamate Source: UniProtKB-HAMAP
  2. arginine catabolic process to succinate Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Arginine metabolismUniRule annotationSAAS annotation

Keywords - Ligandi

Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciVCHO593588:GI2R-2177-MONOMER.
UniPathwayiUPA00185; UER00283.
UPA00185; UER00283.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinylglutamate desuccinylaseUniRule annotationSAAS annotation (EC:3.5.1.96UniRule annotationSAAS annotation)
Gene namesi
Name:astEUniRule annotation
Ordered Locus Names:VCD_003107Imported
OrganismiVibrio cholerae serotype O1 (strain MJ-1236)Imported
Taxonomic identifieri593588 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000001618 Componenti: Chromosome 1

PTM / Processingi

Proteomic databases

PRIDEiC3NR58.

Interactioni

Protein-protein interaction databases

STRINGi593588.VCD_003107.

Structurei

3D structure databases

ProteinModelPortaliC3NR58.
SMRiC3NR58. Positions 3-342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG2988.
HOGENOMiHOG000280300.
KOiK05526.
OMAiFPNPNVA.
OrthoDBiEOG613070.

Family and domain databases

HAMAPiMF_00767. Arg_catab_AstE.
InterProiIPR007036. Aste_AspA.
IPR016681. SuccinylGlu_desuccinylase.
[Graphical view]
PfamiPF04952. AstE_AspA. 1 hit.
[Graphical view]
PIRSFiPIRSF017020. AstE. 1 hit.

Sequencei

Sequence statusi: Complete.

C3NR58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKSLFRQSF LFDSLDLDHP MVAQTVRTEQ GVTLKLHQRG VLEVIPAQTD
60 70 80 90 100
AATKNMVISC GIHGDETAPM ELLDKWIDDI VSGFQPVAER CLFIMAHPQA
110 120 130 140 150
TVRHVRFIEQ NLNRLFDDKP HTPSTELAIA DNLKVLLRQF FANTDEHSRW
160 170 180 190 200
HLDLHCAIRG SKHYSFAVSP KARHPVRSRS LMQFIEQAHI EAVMLSNAPS
210 220 230 240 250
STFSWYSAEH YAAQALTLEL GQVARLGENL LDRLLAFDLA MRDLISRHKP
260 270 280 290 300
EHLPRKSVMY RVSRTIVRLH DDFDFRFSDD VENFTAFMHG EVFGHDGDKP
310 320 330 340
LMAKNEGEAI VFPNRKVAIG QRAALMVCKV NTRYEDDQLV YD
Length:342
Mass (Da):39,093
Last modified:June 16, 2009 - v1
Checksum:iD5D646FA0F6E3796
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001485 Genomic DNA. Translation: ACQ61267.1.
RefSeqiYP_002878837.1. NC_012668.1.

Genome annotation databases

EnsemblBacteriaiACQ61267; ACQ61267; VCD_003107.
GeneIDi7857345.
KEGGivcj:VCD_003107.
PATRICi20077611. VBIVibCho20143_3122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001485 Genomic DNA. Translation: ACQ61267.1.
RefSeqiYP_002878837.1. NC_012668.1.

3D structure databases

ProteinModelPortaliC3NR58.
SMRiC3NR58. Positions 3-342.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi593588.VCD_003107.

Proteomic databases

PRIDEiC3NR58.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACQ61267; ACQ61267; VCD_003107.
GeneIDi7857345.
KEGGivcj:VCD_003107.
PATRICi20077611. VBIVibCho20143_3122.

Phylogenomic databases

eggNOGiCOG2988.
HOGENOMiHOG000280300.
KOiK05526.
OMAiFPNPNVA.
OrthoDBiEOG613070.

Enzyme and pathway databases

UniPathwayiUPA00185; UER00283.
UPA00185; UER00283.
BioCyciVCHO593588:GI2R-2177-MONOMER.

Family and domain databases

HAMAPiMF_00767. Arg_catab_AstE.
InterProiIPR007036. Aste_AspA.
IPR016681. SuccinylGlu_desuccinylase.
[Graphical view]
PfamiPF04952. AstE_AspA. 1 hit.
[Graphical view]
PIRSFiPIRSF017020. AstE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MJ-1236Imported.

Entry informationi

Entry nameiC3NR58_VIBCJ
AccessioniPrimary (citable) accession number: C3NR58
Entry historyi
Integrated into UniProtKB/TrEMBL: June 16, 2009
Last sequence update: June 16, 2009
Last modified: April 1, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.