Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Succinyl-CoA ligase [ADP-forming] subunit alpha

Gene

VCD_002283

Organism
Vibrio cholerae serotype O1 (strain MJ-1236)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei247 – 2471Tele-phosphohistidine intermediateUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP citrate synthase activity Source: InterPro
  3. cofactor binding Source: InterPro
  4. succinate-CoA ligase (ADP-forming) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciVCHO593588:GI2R-1352-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinyl-CoA ligase [ADP-forming] subunit alphaUniRule annotation (EC:6.2.1.5UniRule annotation)
Gene namesi
Ordered Locus Names:VCD_002283Imported
OrganismiVibrio cholerae serotype O1 (strain MJ-1236)Imported
Taxonomic identifieri593588 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000001618 Componenti: Chromosome 1

Interactioni

Subunit structurei

Heterotetramer of two alpha and two beta subunits.UniRule annotation

Protein-protein interaction databases

STRINGi593588.VCD_002283.

Structurei

3D structure databases

ProteinModelPortaliC3NNU1.
SMRiC3NNU1. Positions 2-287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the succinate/malate CoA ligase alpha subunit family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0074.
HOGENOMiHOG000239685.
KOiK01902.
OMAiITEHIPI.
OrthoDBiEOG644ZT0.

Family and domain databases

Gene3Di3.40.50.261. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR017440. Cit_synth/succinyl-CoA_lig_AS.
IPR003781. CoA-bd.
IPR005810. CoA_lig_alpha.
IPR005811. CoA_ligase.
IPR016040. NAD(P)-bd_dom.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]
PfamiPF02629. CoA_binding. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]
PIRSFiPIRSF001553. SucCS_alpha. 1 hit.
PRINTSiPR01798. SCOASYNTHASE.
SMARTiSM00881. CoA_binding. 1 hit.
[Graphical view]
SUPFAMiSSF52210. SSF52210. 1 hit.
TIGRFAMsiTIGR01019. sucCoAalpha. 1 hit.
PROSITEiPS01216. SUCCINYL_COA_LIG_1. 1 hit.
PS00399. SUCCINYL_COA_LIG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C3NNU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILINKDTK VICQGFTGGQ GTFHSEQAIA YGTQMVGGVS PGKGGTTHLG
60 70 80 90 100
LPVFNTVREA VEVTGATATV IYVPAPFCKD AILEAIDAGI KLIVTITEGI
110 120 130 140 150
PTTDMIDVKV KLEQTGVRMI GPNCPGVITP DECKIGIMPG HIHKKGKVGI
160 170 180 190 200
VSRSGTLTYE AVKQTTDEGF GQSTCVGIGG DPIPGSNFID ILKMFQEDPA
210 220 230 240 250
TEAIVMIGEI GGTAEEEAAA FIKANVTKPV VSYIAGVTAP PGKRMGHAGA
260 270 280 290
IISGGKGTAE EKFAALESAG VKTVKSLADI GKALREVTGW
Length:290
Mass (Da):29,941
Last modified:June 15, 2009 - v1
Checksum:i7573EBE60C271086
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001485 Genomic DNA. Translation: ACQ60450.1.
RefSeqiYP_002878020.1. NC_012668.1.

Genome annotation databases

EnsemblBacteriaiACQ60450; ACQ60450; VCD_002283.
GeneIDi7856077.
KEGGivcj:VCD_002283.
PATRICi20075969. VBIVibCho20143_2309.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001485 Genomic DNA. Translation: ACQ60450.1.
RefSeqiYP_002878020.1. NC_012668.1.

3D structure databases

ProteinModelPortaliC3NNU1.
SMRiC3NNU1. Positions 2-287.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi593588.VCD_002283.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACQ60450; ACQ60450; VCD_002283.
GeneIDi7856077.
KEGGivcj:VCD_002283.
PATRICi20075969. VBIVibCho20143_2309.

Phylogenomic databases

eggNOGiCOG0074.
HOGENOMiHOG000239685.
KOiK01902.
OMAiITEHIPI.
OrthoDBiEOG644ZT0.

Enzyme and pathway databases

BioCyciVCHO593588:GI2R-1352-MONOMER.

Family and domain databases

Gene3Di3.40.50.261. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR017440. Cit_synth/succinyl-CoA_lig_AS.
IPR003781. CoA-bd.
IPR005810. CoA_lig_alpha.
IPR005811. CoA_ligase.
IPR016040. NAD(P)-bd_dom.
IPR016102. Succinyl-CoA_synth-like.
[Graphical view]
PfamiPF02629. CoA_binding. 1 hit.
PF00549. Ligase_CoA. 1 hit.
[Graphical view]
PIRSFiPIRSF001553. SucCS_alpha. 1 hit.
PRINTSiPR01798. SCOASYNTHASE.
SMARTiSM00881. CoA_binding. 1 hit.
[Graphical view]
SUPFAMiSSF52210. SSF52210. 1 hit.
TIGRFAMsiTIGR01019. sucCoAalpha. 1 hit.
PROSITEiPS01216. SUCCINYL_COA_LIG_1. 1 hit.
PS00399. SUCCINYL_COA_LIG_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MJ-1236Imported.

Entry informationi

Entry nameiC3NNU1_VIBCJ
AccessioniPrimary (citable) accession number: C3NNU1
Entry historyi
Integrated into UniProtKB/TrEMBL: June 15, 2009
Last sequence update: June 15, 2009
Last modified: January 6, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.