C3NNU1 (C3NNU1_VIBCJ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Succinyl-CoA ligase [ADP-forming] subunit alpha RuleBase RU000699
EC=6.2.1.5 RuleBase RU000699

Gene names

Ordered Locus Names:

VCD_002283

Organism

Vibrio cholerae serotype O1 (strain MJ-1236) [Complete proteome] [HAMAP] EMBL ACQ60450.1

Taxonomic identifier

593588 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio › Vibrio cholerae › Vibrio cholerae O1

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + succinate + CoA = ADP + phosphate + succinyl-CoA. RuleBase RU000699
Subunit structure	Heterotetramer of two alpha and two beta subunits By similarity. RuleBase RU000699
Sequence similarities	Belongs to the succinate/malate CoA ligase alpha subunit family. RuleBase RU000677

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000699 Nucleotide-binding
Molecular function	Ligase RuleBase RU000677 EMBL ACQ60450.1
PTM	Phosphoprotein RuleBase RU000677
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP citrate synthase activity Inferred from electronic annotation. Source: InterPro cofactor binding Inferred from electronic annotation. Source: InterPro succinate-CoA ligase (ADP-forming) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	247	1	Tele-phosphohistidine intermediate By similarity PIRSR PIRSR001553-1

Sequences

	Sequence		Length	Mass (Da)
	C3NNU1 [UniParc]. Last modified June 16, 2009. Version 1. Checksum: 7573EBE60C271086	FASTA	290	29,941
	10 20 30 40 50 60 MSILINKDTK VICQGFTGGQ GTFHSEQAIA YGTQMVGGVS PGKGGTTHLG LPVFNTVREA 70 80 90 100 110 120 VEVTGATATV IYVPAPFCKD AILEAIDAGI KLIVTITEGI PTTDMIDVKV KLEQTGVRMI 130 140 150 160 170 180 GPNCPGVITP DECKIGIMPG HIHKKGKVGI VSRSGTLTYE AVKQTTDEGF GQSTCVGIGG 190 200 210 220 230 240 DPIPGSNFID ILKMFQEDPA TEAIVMIGEI GGTAEEEAAA FIKANVTKPV VSYIAGVTAP 250 260 270 280 290 PGKRMGHAGA IISGGKGTAE EKFAALESAG VKTVKSLADI GKALREVTGW

References

[1]

"Comparative genomics reveals mechanism for short-term and long-term clonal transitions in pandemic Vibrio cholerae." Chun J., Grim C.J., Hasan N.A., Lee J.H., Choi S.Y., Haley B.J., Taviani E., Jeon Y.-S., Kim D.W., Lee J.-H., Brettin T.S., Bruce D.C., Challacombe J.F., Detter J.C., Han C.S., Munk A.C., Chertkov O., Meincke L. , Saunders E., Walters R.A., Huq A., Nair G.B., Colwell R.R. Proc. Natl. Acad. Sci. U.S.A. 106:15442-15447(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MJ-1236.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001485 Genomic DNA. Translation: ACQ60450.1.
RefSeq	YP_002878020.1. NC_012668.1.
3D structure databases
ProteinModelPortal	C3NNU1.
SMR	C3NNU1. Positions 2-287.
ModBase	Search...
Protein-protein interaction databases
STRING	593588.VCD_002283.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACQ60450; ACQ60450; VCD_002283.
GeneID	7856077.
KEGG	vcj:VCD_002283.
PATRIC	20075969. VBIVibCho20143_2309.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0074.
HOGENOM	HOG000239685.
KO	K01902.
OMA	KGRKKPM.
ProtClustDB	PRK05678.
Family and domain databases
Gene3D	3.40.50.261. 1 hit. 3.40.50.720. 1 hit.
InterPro	IPR017440. Cit_synth/succinyl-CoA_lig_AS. IPR003781. CoA-bd. IPR005810. CoA_lig_alpha. IPR005811. CoA_ligase. IPR016040. NAD(P)-bd_dom. IPR016102. Succinyl-CoA_synth-like. [Graphical view]
Pfam	PF02629. CoA_binding. 1 hit. PF00549. Ligase_CoA. 1 hit. [Graphical view]
PIRSF	PIRSF001553. SucCS_alpha. 1 hit.
PRINTS	PR01798. SCOASYNTHASE.
SMART	SM00881. CoA_binding. 1 hit. [Graphical view]
SUPFAM	SSF52210. CoA_ligase. 1 hit.
TIGRFAMs	TIGR01019. sucCoAalpha. 1 hit.
PROSITE	PS01216. SUCCINYL_COA_LIG_1. 1 hit. PS00399. SUCCINYL_COA_LIG_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C3NNU1_VIBCJ

Accession

Primary (citable) accession number: C3NNU1

Entry history

Integrated into UniProtKB/TrEMBL:	June 16, 2009
Last sequence update:	June 16, 2009
Last modified:	May 1, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)