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C3NHN8

- GCSPA_SULIN

UniProt

C3NHN8 - GCSPA_SULIN

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 1
Gene
gcvPA, YN1551_1560
Organism
Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciSISL419942:GHVO-1618-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:YN1551_1560
OrganismiSulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)
Taxonomic identifieri419942 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000006818: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation
PRO_1000212668Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi419942.YN1551_1560.

Structurei

3D structure databases

ProteinModelPortaliC3NHN8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiRLVGQTE.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

C3NHN8-1 [UniParc]FASTAAdd to Basket

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MYKHPWLPNL DLIDEMLKEI GVNSLDELFN DIPAEIKINR LLNVAKGKPL    50
SEYEIEKEIN EKVKKNVELQ APPFIGAGIC PHYIPNVVKF IIGRSEFYTS 100
YTPYQPEISQ GLLQALFEYQ SLMAELLDMD VVNASMYDWG SALAEAVLMA 150
NRINGKKTVL VPENANPFHK EVVRTWIGGK GIKIEEVKYD KNSGELDLED 200
LEKKSNIDDI SAIYIQQPNF FGIFESNIEH VIDVAKHKRA LSIVGVNPLS 250
LGLIKPPGSY EADIVVGDGQ ELGLPLNFGG PLMGVFAVRW DMSLVRQMPG 300
RIVGITKDTN GKMGFTLILQ TREQFIKREK ATSNITTNEA LLAIANAVYL 350
SLLGKEGMRE LAEEIYFRSH YAAKKLTEID NVSMPFRSDF FEEFAIRFPI 400
EYDKISNKLK ERKLQGGLKL SDYTSLFCVT EVHDKKSIDL LVSTIQEMIN 450
GVETS 455
Length:455
Mass (Da):51,276
Last modified:June 16, 2009 - v1
Checksum:iE7A42776D179E532
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001404 Genomic DNA. Translation: ACP48648.1.
RefSeqiYP_002840570.1. NC_012623.1.

Genome annotation databases

EnsemblBacteriaiACP48648; ACP48648; YN1551_1560.
GeneIDi7809151.
KEGGisin:YN1551_1560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001404 Genomic DNA. Translation: ACP48648.1 .
RefSeqi YP_002840570.1. NC_012623.1.

3D structure databases

ProteinModelPortali C3NHN8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 419942.YN1551_1560.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACP48648 ; ACP48648 ; YN1551_1560 .
GeneIDi 7809151.
KEGGi sin:YN1551_1560.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi RLVGQTE.

Enzyme and pathway databases

BioCyci SISL419942:GHVO-1618-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Y.N.15.51 / Yellowstone #2.

Entry informationi

Entry nameiGCSPA_SULIN
AccessioniPrimary (citable) accession number: C3NHN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: September 3, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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