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Protein

Probable N-glycosylase/DNA lyase

Gene

ogg

Organism
Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites).UniRule annotation

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei128UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase, Lyase
Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-glycosylase/DNA lyaseUniRule annotation
Including the following 2 domains:
8-oxoguanine DNA glycosylaseUniRule annotation (EC:3.2.2.-UniRule annotation)
DNA-(apurinic or apyrimidinic site) lyaseUniRule annotation (EC:4.2.99.18UniRule annotation)
Short name:
AP lyaseUniRule annotation
Gene namesi
Name:oggUniRule annotation
Ordered Locus Names:YN1551_1546
OrganismiSulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)
Taxonomic identifieri419942 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000006818 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002044731 – 207Probable N-glycosylase/DNA lyaseAdd BLAST207

Structurei

3D structure databases

SMRiC3NHM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type-2 OGG1 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000224507.
KOiK03653.
OMAiELCFCIL.
OrthoDBiPOG093Z0AOL.

Family and domain databases

CDDicd00056. ENDO3c. 1 hit.
Gene3Di1.10.340.30. 1 hit.
HAMAPiMF_00241. Ogg. 1 hit.
InterProiView protein in InterPro
IPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
SMARTiView protein in SMART
SM00478. ENDO3c. 1 hit.
SUPFAMiSSF48150. SSF48150. 1 hit.

Sequencei

Sequence statusi: Complete.

C3NHM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRSLVQNPR VRARVLERVD EFRLNNLSNE EVWFRELTLC LLTANSSFIS
60 70 80 90 100
AYQALNCLGD KIYYANEEVI RSILKSCKYR FYNLKAKYII MAREKVYGKL
110 120 130 140 150
KEEITPLADS DQQLAREKLL NIKGIGMKEA SHFLRNVGYF DLAIIDRHLI
160 170 180 190 200
DFMRRIGAIG EINVKHLSKS RYISLESVLK SIALNLNISV GILDLFIWYK

ETNTIVK
Length:207
Mass (Da):24,083
Last modified:June 16, 2009 - v1
Checksum:i2C5EDB4A5C41CF4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001404 Genomic DNA. Translation: ACP48634.1.
RefSeqiWP_012717491.1. NC_012623.1.

Genome annotation databases

EnsemblBacteriaiACP48634; ACP48634; YN1551_1546.
GeneIDi7809137.
KEGGisin:YN1551_1546.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001404 Genomic DNA. Translation: ACP48634.1.
RefSeqiWP_012717491.1. NC_012623.1.

3D structure databases

SMRiC3NHM4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACP48634; ACP48634; YN1551_1546.
GeneIDi7809137.
KEGGisin:YN1551_1546.

Phylogenomic databases

HOGENOMiHOG000224507.
KOiK03653.
OMAiELCFCIL.
OrthoDBiPOG093Z0AOL.

Family and domain databases

CDDicd00056. ENDO3c. 1 hit.
Gene3Di1.10.340.30. 1 hit.
HAMAPiMF_00241. Ogg. 1 hit.
InterProiView protein in InterPro
IPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
SMARTiView protein in SMART
SM00478. ENDO3c. 1 hit.
SUPFAMiSSF48150. SSF48150. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiOGG1_SULIN
AccessioniPrimary (citable) accession number: C3NHM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: March 15, 2017
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.