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C3NHM4 (OGG1_SULIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable N-glycosylase/DNA lyase

Including the following 2 domains:

  1. 8-oxoguanine DNA glycosylase
    EC=3.2.2.-
  2. DNA-(apurinic or apyrimidinic site) lyase
    Short name=AP lyase
    EC=4.2.99.18
Gene names
Name:ogg
Ordered Locus Names:YN1551_1546
OrganismSulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2) [Complete proteome] [HAMAP]
Taxonomic identifier419942 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length207 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) By similarity. HAMAP-Rule MF_00241

Catalytic activity

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. HAMAP-Rule MF_00241

Sequence similarities

Belongs to the type-2 OGG1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 207207Probable N-glycosylase/DNA lyase HAMAP-Rule MF_00241
PRO_1000204473

Sites

Active site1281 By similarity

Sequences

Sequence LengthMass (Da)Tools
C3NHM4 [UniParc].

Last modified June 16, 2009. Version 1.
Checksum: 2C5EDB4A5C41CF4A

FASTA20724,083
        10         20         30         40         50         60 
MLRSLVQNPR VRARVLERVD EFRLNNLSNE EVWFRELTLC LLTANSSFIS AYQALNCLGD 

        70         80         90        100        110        120 
KIYYANEEVI RSILKSCKYR FYNLKAKYII MAREKVYGKL KEEITPLADS DQQLAREKLL 

       130        140        150        160        170        180 
NIKGIGMKEA SHFLRNVGYF DLAIIDRHLI DFMRRIGAIG EINVKHLSKS RYISLESVLK 

       190        200 
SIALNLNISV GILDLFIWYK ETNTIVK 

« Hide

References

[1]"Biogeography of the Sulfolobus islandicus pan-genome."
Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.
Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Y.N.15.51 / Yellowstone #2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001404 Genomic DNA. Translation: ACP48634.1.
RefSeqYP_002840556.1. NC_012623.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING419942.YN1551_1546.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACP48634; ACP48634; YN1551_1546.
GeneID7809137.
KEGGsin:YN1551_1546.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1059.
HOGENOMHOG000224507.
KOK03653.
OMALDLYLWY.

Enzyme and pathway databases

BioCycSISL419942:GHVO-1604-MONOMER.

Family and domain databases

Gene3D1.10.340.30. 1 hit.
HAMAPMF_00241. Ogg.
InterProIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PfamPF00730. HhH-GPD. 1 hit.
[Graphical view]
PIRSFPIRSF005954. Thrmst_ogg. 1 hit.
SMARTSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMSSF48150. SSF48150. 1 hit.
ProtoNetSearch...

Entry information

Entry nameOGG1_SULIN
AccessionPrimary (citable) accession number: C3NHM4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 16, 2009
Last modified: May 14, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families