C3NH11 (C3NH11_SULIN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137
EC=6.3.2.6 HAMAP MF_00137

Alternative name(s):
SAICAR synthetase HAMAP MF_00137

Gene names

Name:	purC HAMAP MF_00137
Ordered Locus Names:	YN1551_1326

Organism

Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2) [Complete proteome] [HAMAP]

Taxonomic identifier

419942 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	233 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137
Sequence similarities	Belongs to the SAICAR synthetase family. HAMAP MF_00137 RuleBase RU004193

Ontologies

Keywords
Biological process	Purine biosynthesis HAMAP MF_00137
Ligand	ATP-binding HAMAP MF_00137 Nucleotide-binding
Molecular function	Ligase HAMAP MF_00137 EMBL ACP48421.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C3NH11 [UniParc]. Last modified June 16, 2009. Version 1. Checksum: 36F69E9F101D21E3	FASTA	233	27,312
	10 20 30 40 50 60 MEVNKISEGK TKIVYDFDKD HVLLRFKDDI TAGDGQKRDV MEGKGVLNAQ TSAFFFRLLE 70 80 90 100 110 120 RNGIETHYVG MKDERTMIVK KLKMIPVEVV LRNIATGSIV KRLPIKEGEV FEPPIVEFFL 130 140 150 160 170 180 KDDLRHDPLL NYYHMEHLKL MSRKEAQYIE DIMMKTNDVL FNFIKNKGLI LYDFKLEFGR 190 200 210 220 230 LGDKLVIGDE ISLDSMRIRD PNSRIYDKDL YRKGYDLKTV KASYEEFLKR IAS

References

[1]	"Biogeography of the Sulfolobus islandicus pan-genome." Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J. Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009) [PubMed: 19435847] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001404 Genomic DNA. Translation: ACP48421.1.
RefSeq	YP_002840343.1. NC_012623.1.
3D structure databases
ProteinModelPortal	C3NH11.
ModBase	Search...
Protein-protein interaction databases
STRING	C3NH11.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7810111.
GenomeReviews	Gene locus YN1551_1326 in contig CP001404_GR.
KEGG	sin:YN1551_1326.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	YKDDALG.
ProtClustDB	PRK09362.
Family and domain databases
HAMAP	MF_00137. SAICAR_synth. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synth. IPR018236. SAICAR_synthetase_CS. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KO	K01923.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR00081. PurC. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C3NH11_SULIN

Accession

Primary (citable) accession number: C3NH11

Entry history

Integrated into UniProtKB/TrEMBL:	June 16, 2009
Last sequence update:	June 16, 2009
Last modified:	November 16, 2011
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)